STRINGSTRING
tbx3 tbx3 ptch1-2 ptch1-2 lef1-2 lef1-2 fgf8 fgf8 sfrp2-2 sfrp2-2 ctnnb1-2 ctnnb1-2 hoxd10 hoxd10 ctnnb1 ctnnb1 dlx6-2 dlx6-2 en1-2 en1-2 hoxd11 hoxd11 dlx6 dlx6 Pkdcc2 Pkdcc2 A0A1L8EKM7 A0A1L8EKM7 A0A1L8EKQ1 A0A1L8EKQ1 Sall4.S Sall4.S itgb4 itgb4 en1 en1 A0A1L8ENZ6 A0A1L8ENZ6 A0A1L8EP79 A0A1L8EP79 A0A1L8EP98 A0A1L8EP98 Hoxd13.S Hoxd13.S A0A1L8EPB4 A0A1L8EPB4 A0A1L8EPQ2 A0A1L8EPQ2 A0A1L8EPQ9 A0A1L8EPQ9 Bmpr2.S Bmpr2.S A0A1L8EPT8 A0A1L8EPT8 A0A1L8EQU0 A0A1L8EQU0 Kremen2.S Kremen2.S Rara.L Rara.L med1l med1l sall4 sall4 itgb4-2 itgb4-2 A0A1L8EW93 A0A1L8EW93 hoxd13 hoxd13 A0A1L8EWC8 A0A1L8EWC8 bmpr2 bmpr2 iqce iqce A0A1L8EYA0 A0A1L8EYA0 b9d1 b9d1 kremen2 kremen2 A0A1L8EZY9 A0A1L8EZY9 Pkdcc.1.S Pkdcc.1.S A0A1L8F2G2 A0A1L8F2G2 atrx atrx Eylp01 Eylp01 psen1 psen1 slc39a1 slc39a1 A0A1L8FDB0 A0A1L8FDB0 A0A1L8FEK1 A0A1L8FEK1 A0A1L8FG23 A0A1L8FG23 Bax.L Bax.L dkk1 dkk1 A0A1L8FJD8 A0A1L8FJD8 A0A1L8FLW6 A0A1L8FLW6 dlx5 dlx5 Meox2.S Meox2.S hoxa11 hoxa11 hoxa10 hoxa10 A0A1L8FRE1 A0A1L8FRE1 gli3 gli3 tfap2a tfap2a A0A1L8FS70 A0A1L8FS70 Sall3.S Sall3.S impad1 impad1 Rdh10.S Rdh10.S osr2 osr2 Dlx5.L Dlx5.L Meox2.L Meox2.L A0A1L8FW21 A0A1L8FW21 hoxa11-2 hoxa11-2 A0A1L8FW54 A0A1L8FW54 A0A1L8FW56 A0A1L8FW56 A0A1L8FW99 A0A1L8FW99 A0A1L8FWE1 A0A1L8FWE1 gli3-2 gli3-2 Med1.L Med1.L A0A1L8FX32 A0A1L8FX32 A0A1L8FXS7 A0A1L8FXS7 Tfap2a.L Tfap2a.L sall3 sall3 impad1-2 impad1-2 osr2-2 osr2-2 Pkdcc1 Pkdcc1 bcl2l11 bcl2l11 tp63 tp63 osr1 osr1 A0A1L8G5L2 A0A1L8G5L2 wdpcp wdpcp bcl2l11-2 bcl2l11-2 A0A1L8G7I9 A0A1L8G7I9 tp63-2 tp63-2 ift80 ift80 osr1-2 osr1-2 hoxd9 hoxd9 A0A310TMV5 A0A310TMV5 Taf10.L Taf10.L A0A1L8I318 A0A1L8I318 Rnf165.L Rnf165.L A0A1L8I2V3 A0A1L8I2V3 nipbl nipbl pam-2 pam-2 znrf3 znrf3 kremen1 kremen1 ptch1 ptch1 gas1-2 gas1-2 slc39a3-2 slc39a3-2 Pias4.L Pias4.L Fras1.L Fras1.L slc7a11-2 slc7a11-2 bbs7 bbs7 sfrp2 sfrp2 hand2 hand2 wdr19 wdr19 cyp26b1-2 cyp26b1-2 Rnf165.S Rnf165.S A0A1L8HRY9 A0A1L8HRY9 A0A1L8HRR4 A0A1L8HRR4 pam pam Znrf3.S Znrf3.S Kremen1.S Kremen1.S tbx5 tbx5 gas1 gas1 slc39a3 slc39a3 Pias4.S Pias4.S A0A1L8HMJ6 A0A1L8HMJ6 lef1 lef1 slc7a11 slc7a11 Intu.S Intu.S A0A1L8HLI5 A0A1L8HLI5 msx1 msx1 cyp26b1 cyp26b1 Dync2h1.L Dync2h1.L frem2 frem2 A0A1L8HIJ2 A0A1L8HIJ2 A0A1L8HII8 A0A1L8HII8 Hoxc10.L Hoxc10.L hoxc13-2 hoxc13-2 A0A1L8HIF1 A0A1L8HIF1 tbx4 tbx4 tfap2e-2 tfap2e-2 Med31.L Med31.L Foxn1.L Foxn1.L A0A1L8HAE8 A0A1L8HAE8 hoxc13 hoxc13 A0A1L8HAC0 A0A1L8HAC0 A0A1L8HA71 A0A1L8HA71 Rarg.S Rarg.S A0A1L8HA36 A0A1L8HA36 A0A1L8H810 A0A1L8H810 A0A1L8H804 A0A1L8H804 tfap2e tfap2e kdf1 kdf1 med31 med31 Foxn1.S Foxn1.S A0A1L8H3C9 A0A1L8H3C9 sema3c sema3c A0A1L8GY96 A0A1L8GY96 A0A1L8GUW0 A0A1L8GUW0 Sema3c.S Sema3c.S A0A1L8GQE6 A0A1L8GQE6 A0A1L8GKM8 A0A1L8GKM8 Rpgrip1l.L Rpgrip1l.L Lrp5.L Lrp5.L Fgf4.L Fgf4.L A0A1L8GEC5 A0A1L8GEC5 fgf4 fgf4 ift172 ift172 A0A1L8GCF6 A0A1L8GCF6 tbx5-2 tbx5-2 Tbx2 Tbx2 tbx3-A tbx3-A rspo2 rspo2 nog nog kdf1-2 kdf1-2 msx1-2 msx1-2 hoxa9 hoxa9 mks1 mks1 dkk1-2 dkk1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx3Transcription factor Tbx3. (711 aa)
ptch1-2Patched-1. (1418 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
ctnnb1-2Ctnnb1-prov protein. (781 aa)
hoxd10Hoxd10 protein. (337 aa)
ctnnb1Beta-catenin protein. (781 aa)
dlx6-2MGC130625 protein. (253 aa)
en1-2Homeobox protein engrailed-like. (229 aa)
hoxd11MGC131014 protein. (274 aa)
dlx6LOC443711 protein. (260 aa)
Pkdcc2Protein kinase domain containing, cytoplasmic 2. (480 aa)
A0A1L8EKM7Uncharacterized protein. (464 aa)
A0A1L8EKQ1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
Sall4.SUncharacterized protein. (1077 aa)
itgb4Integrin beta. (1770 aa)
en1Homeobox protein engrailed-like. (228 aa)
A0A1L8ENZ6SSD domain-containing protein. (946 aa)
A0A1L8EP79Uncharacterized protein. (788 aa)
A0A1L8EP98Homeobox domain-containing protein. (338 aa)
Hoxd13.SHomeobox domain-containing protein. (296 aa)
A0A1L8EPB4Homeobox domain-containing protein. (274 aa)
A0A1L8EPQ2Uncharacterized protein. (181 aa)
A0A1L8EPQ9Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (130 aa)
Bmpr2.SUncharacterized protein. (383 aa)
A0A1L8EPT8Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (144 aa)
A0A1L8EQU0Uncharacterized protein. (176 aa)
Kremen2.SUncharacterized protein. (421 aa)
Rara.LUncharacterized protein. (461 aa)
med1lMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
sall4Uncharacterized protein. (1063 aa)
itgb4-2Integrin beta. (1770 aa)
A0A1L8EW93Uncharacterized protein. (793 aa)
hoxd13Homeobox domain-containing protein. (299 aa)
A0A1L8EWC8Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (274 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1054 aa)
iqceUncharacterized protein. (735 aa)
A0A1L8EYA0Uncharacterized protein. (1461 aa)
b9d1Uncharacterized protein. (236 aa)
kremen2Uncharacterized protein. (420 aa)
A0A1L8EZY9Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
Pkdcc.1.SProtein kinase domain-containing protein. (470 aa)
A0A1L8F2G2PHD-type domain-containing protein. (1187 aa)
atrxUncharacterized protein. (2276 aa)
Eylp01Protein kinase domain-containing protein. (462 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
slc39a1Uncharacterized protein. (319 aa)
A0A1L8FDB0Mothers against decapentaplegic homolog. (514 aa)
A0A1L8FEK1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
A0A1L8FG23Uncharacterized protein. (658 aa)
Bax.LUncharacterized protein. (221 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
A0A1L8FJD8Uncharacterized protein. (395 aa)
A0A1L8FLW6Uncharacterized protein. (660 aa)
dlx5Homeobox domain-containing protein. (297 aa)
Meox2.SHomeobox domain-containing protein. (298 aa)
hoxa11Homeobox domain-containing protein. (298 aa)
hoxa10Homeobox domain-containing protein. (352 aa)
A0A1L8FRE1Uncharacterized protein. (447 aa)
gli3Uncharacterized protein. (1565 aa)
tfap2aTF_AP-2 domain-containing protein. (470 aa)
A0A1L8FS70Uncharacterized protein. (704 aa)
Sall3.SUncharacterized protein. (1259 aa)
impad1Uncharacterized protein. (351 aa)
Rdh10.SUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
osr2Uncharacterized protein. (271 aa)
Dlx5.LHomeobox domain-containing protein. (298 aa)
Meox2.LHomeobox domain-containing protein. (301 aa)
A0A1L8FW21Homeobox domain-containing protein. (90 aa)
hoxa11-2Homeobox domain-containing protein. (299 aa)
A0A1L8FW54Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (258 aa)
A0A1L8FW56Uncharacterized protein. (267 aa)
A0A1L8FW99Uncharacterized protein. (52 aa)
A0A1L8FWE1Uncharacterized protein. (395 aa)
gli3-2Uncharacterized protein. (1568 aa)
Med1.LMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (649 aa)
A0A1L8FX32Uncharacterized protein. (971 aa)
A0A1L8FXS7Uncharacterized protein. (705 aa)
Tfap2a.LTF_AP-2 domain-containing protein. (472 aa)
sall3Uncharacterized protein. (1278 aa)
impad1-2Uncharacterized protein. (356 aa)
osr2-2Uncharacterized protein. (312 aa)
Pkdcc1Protein kinase domain-containing protein. (535 aa)
bcl2l11Uncharacterized protein. (194 aa)
tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
osr1Uncharacterized protein. (259 aa)
A0A1L8G5L2TF_AP-2 domain-containing protein. (441 aa)
wdpcpUncharacterized protein. (708 aa)
bcl2l11-2Uncharacterized protein. (194 aa)
A0A1L8G7I9Uncharacterized protein. (453 aa)
tp63-2Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
ift80WD_REPEATS_REGION domain-containing protein. (779 aa)
osr1-2Uncharacterized protein. (259 aa)
hoxd9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (273 aa)
A0A310TMV5Uncharacterized protein. (3124 aa)
Taf10.LUncharacterized protein. (107 aa)
A0A1L8I318Uncharacterized protein. (173 aa)
Rnf165.LRING-type domain-containing protein. (348 aa)
A0A1L8I2V3Mothers against decapentaplegic homolog. (510 aa)
nipblNipped-B protein. (2844 aa)
pam-2Uncharacterized protein. (1042 aa)
znrf3RING-type domain-containing protein. (854 aa)
kremen1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
ptch1SSD domain-containing protein. (1422 aa)
gas1-2Uncharacterized protein. (284 aa)
slc39a3-2Uncharacterized protein. (314 aa)
Pias4.LUncharacterized protein. (544 aa)
Fras1.LUncharacterized protein. (3935 aa)
slc7a11-2Uncharacterized protein. (500 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (716 aa)
sfrp2Uncharacterized protein. (295 aa)
hand2BHLH domain-containing protein. (210 aa)
wdr19WD_REPEATS_REGION domain-containing protein. (1344 aa)
cyp26b1-2Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
Rnf165.SRING-type domain-containing protein. (348 aa)
A0A1L8HRY9Mothers against decapentaplegic homolog. (549 aa)
A0A1L8HRR4Nipped-B protein. (1728 aa)
pamUncharacterized protein. (875 aa)
Znrf3.SRING-type domain-containing protein. (848 aa)
Kremen1.SKremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
tbx5Uncharacterized protein. (519 aa)
gas1Uncharacterized protein. (299 aa)
slc39a3Uncharacterized protein. (314 aa)
Pias4.SUncharacterized protein. (543 aa)
A0A1L8HMJ6Uncharacterized protein. (3915 aa)
lef1HMG box domain-containing protein. (372 aa)
slc7a11Uncharacterized protein. (500 aa)
Intu.SPDZ domain-containing protein. (951 aa)
A0A1L8HLI5BHLH domain-containing protein. (272 aa)
msx1Homeobox domain-containing protein. (275 aa)
cyp26b1Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
Dync2h1.LUncharacterized protein. (2548 aa)
frem2Uncharacterized protein. (3108 aa)
A0A1L8HIJ2Uncharacterized protein. (442 aa)
A0A1L8HII8Uncharacterized protein. (130 aa)
Hoxc10.LHomeobox domain-containing protein. (351 aa)
hoxc13-2Homeobox domain-containing protein. (307 aa)
A0A1L8HIF1Homeobox domain-containing protein. (309 aa)
tbx4Uncharacterized protein. (541 aa)
tfap2e-2TF_AP-2 domain-containing protein. (434 aa)
Med31.LMediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (128 aa)
Foxn1.LFork-head domain-containing protein. (667 aa)
A0A1L8HAE8Uncharacterized protein. (2957 aa)
hoxc13Homeobox domain-containing protein. (306 aa)
A0A1L8HAC0Uncharacterized protein. (121 aa)
A0A1L8HA71Homeobox domain-containing protein. (91 aa)
Rarg.SUncharacterized protein. (442 aa)
A0A1L8HA36Homeobox domain-containing protein. (309 aa)
A0A1L8H810Uncharacterized protein. (540 aa)
A0A1L8H804TBX domain-containing protein. (642 aa)
tfap2eTF_AP-2 domain-containing protein. (435 aa)
kdf1Uncharacterized protein. (347 aa)
med31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (129 aa)
Foxn1.SFork-head domain-containing protein. (646 aa)
A0A1L8H3C9Uncharacterized protein. (118 aa)
sema3cUncharacterized protein; Belongs to the semaphorin family. (748 aa)
A0A1L8GY96Carbohydrate sulfotransferase. (352 aa)
A0A1L8GUW0Carbohydrate sulfotransferase. (352 aa)
Sema3c.SUncharacterized protein; Belongs to the semaphorin family. (748 aa)
A0A1L8GQE6Uncharacterized protein. (482 aa)
A0A1L8GKM8Uncharacterized protein. (1234 aa)
Rpgrip1l.LC2 domain-containing protein. (1243 aa)
Lrp5.LUncharacterized protein. (1517 aa)
Fgf4.LFibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
A0A1L8GEC5Uncharacterized protein. (1376 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
ift172Uncharacterized protein. (1749 aa)
A0A1L8GCF6TF_AP-2 domain-containing protein. (427 aa)
tbx5-2T-box transcription factor Tbx5. (519 aa)
Tbx2T-box transcription factor Tbx2. (688 aa)
tbx3-ATranscription repression factor Tbx3. (716 aa)
rspo2R-spondin 2. (243 aa)
nogNoggin; Belongs to the noggin family. (222 aa)
kdf1-2LOC100137694 protein. (362 aa)
msx1-2LOC100125666 protein. (273 aa)
hoxa9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (261 aa)
mks1Mks1 protein. (561 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (26%) [HD]