(30 nodes) Adipose tissue development network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	Arid5b.S	ARID domain-containing protein. (1011 aa)
	A0A1L8F791	Uncharacterized protein. (1177 aa)
	A0A1L8F2I8	Uncharacterized protein. (1067 aa)
	Sox8.L	HMG box domain-containing protein. (459 aa)
	dhrs7b	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
	sox8	HMG box domain-containing protein. (461 aa)
	Dhrs7b.S	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	A0A1L8FIU9	Uncharacterized protein. (167 aa)
	Znf516.S	Uncharacterized protein. (1156 aa)
	znf516	Uncharacterized protein. (1153 aa)
	vps13b	Uncharacterized protein. (4031 aa)
	A0A1L8G3Z7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	A0A1L8GA65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	A0A1L8GTC8	TPR_REGION domain-containing protein. (516 aa)
	sh3pxd2b	Uncharacterized protein. (901 aa)
	sh3pxd2b-2	Uncharacterized protein. (912 aa)
	A0A1L8FIU2	ARID domain-containing protein. (1011 aa)
	A0A1L8HC89	Uncharacterized protein. (1069 aa)
	spart	MIT domain-containing protein. (595 aa)
	ppargc1a	RRM domain-containing protein. (784 aa)
	A0A1L8HPT4	Sep15_SelM domain-containing protein. (121 aa)
	A0A1L8HQW3	BZIP domain-containing protein. (433 aa)
	ppargc1a-2	RRM domain-containing protein. (786 aa)
	A0A1L8HZS4	Sep15_SelM domain-containing protein. (124 aa)
	A0A1L8I199	BZIP domain-containing protein. (390 aa)
	pgrmc2	MGC131268 protein; Belongs to the cytochrome b5 family. (194 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	pgrmc2-2	MGC84241 protein; Belongs to the cytochrome b5 family. (194 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F2I8	Lrp5.L	A0A1L8F2I8	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A1L8F791	Lrp5.L	A0A1L8F791	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.496
Lrp5.L	A0A1L8F2I8	A0A1L8GJX4	A0A1L8F2I8	Uncharacterized protein.	Uncharacterized protein.	0.496
Lrp5.L	A0A1L8F791	A0A1L8GJX4	A0A1L8F791	Uncharacterized protein.	Uncharacterized protein.	0.496
lep	lep-2	A0A1L8GZQ3	Q563I5	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.900
lep	ppargc1a	A0A1L8GZQ3	A0A1L8HKX9	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	RRM domain-containing protein.	0.418
lep	ppargc1a-2	A0A1L8GZQ3	A0A1L8HTJ1	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	RRM domain-containing protein.	0.418
lep-2	lep	Q563I5	A0A1L8GZQ3	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.900
lep-2	ppargc1a	Q563I5	A0A1L8HKX9	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	RRM domain-containing protein.	0.418
lep-2	ppargc1a-2	Q563I5	A0A1L8HTJ1	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	RRM domain-containing protein.	0.418
ppargc1a	lep	A0A1L8HKX9	A0A1L8GZQ3	RRM domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.418
ppargc1a	lep-2	A0A1L8HKX9	Q563I5	RRM domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.418
ppargc1a	ppargc1a-2	A0A1L8HKX9	A0A1L8HTJ1	RRM domain-containing protein.	RRM domain-containing protein.	0.900
ppargc1a-2	lep	A0A1L8HTJ1	A0A1L8GZQ3	RRM domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.418
ppargc1a-2	lep-2	A0A1L8HTJ1	Q563I5	RRM domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.418
ppargc1a-2	ppargc1a	A0A1L8HTJ1	A0A1L8HKX9	RRM domain-containing protein.	RRM domain-containing protein.	0.900