(43 nodes) Positive regulation of cartilage development network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bmp6	TGF_BETA_2 domain-containing protein. (448 aa)
	Pkdcc2	Protein kinase domain containing, cytoplasmic 2. (480 aa)
	gdf5	TGF_BETA_2 domain-containing protein. (496 aa)
	A0A1L8EPQ2	Uncharacterized protein. (181 aa)
	A0A1L8EPQ9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (130 aa)
	Bmpr2.S	Uncharacterized protein. (383 aa)
	A0A1L8EPT8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (144 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1054 aa)
	Pkdcc.1.S	Protein kinase domain-containing protein. (470 aa)
	Eylp01	Protein kinase domain-containing protein. (462 aa)
	A0A1L8FG23	Uncharacterized protein. (658 aa)
	gdf2	TGF_BETA_2 domain-containing protein. (409 aa)
	A0A1L8FLW6	Uncharacterized protein. (660 aa)
	gli3	Uncharacterized protein. (1565 aa)
	Bmp6.S	TGF_BETA_2 domain-containing protein. (448 aa)
	gli3-2	Uncharacterized protein. (1568 aa)
	A0A1L8FZP6	TGF_BETA_2 domain-containing protein. (399 aa)
	Pkdcc1	Protein kinase domain-containing protein. (535 aa)
	Loxl2.L	Uncharacterized protein. (765 aa)
	bmp10-2	TGF_BETA_2 domain-containing protein. (421 aa)
	A0A1L8GVX2	HMG box domain-containing protein. (810 aa)
	bmp10	TGF_BETA_2 domain-containing protein. (421 aa)
	loxl3	Uncharacterized protein. (800 aa)
	loxl2	Uncharacterized protein. (767 aa)
	Sox5.S	HMG box domain-containing protein. (742 aa)
	A0A1L8GLM2	Uncharacterized protein. (375 aa)
	Mdk.L	Uncharacterized protein. (173 aa)
	A0A1L8GIA5	HMG box domain-containing protein. (775 aa)
	A0A1L8GF46	Uncharacterized protein. (343 aa)
	mdk	Uncharacterized protein. (142 aa)
	Bmp2.L	TGF_BETA_2 domain-containing protein. (398 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (398 aa)
	Tapt1.S	Uncharacterized protein. (546 aa)
	smad7	Mothers against decapentaplegic homolog. (382 aa)
	tapt1	Uncharacterized protein. (545 aa)
	A0A1L8HUK7	Mothers against decapentaplegic homolog. (422 aa)
	A0A1L8I318	Uncharacterized protein. (173 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	GDF6	Growth and differentiation factor 6. (399 aa)
	sox6	SRY-box 6. (760 aa)
	smad7-2	Mothers against decapentaplegic homolog. (382 aa)
	gdf5-2	Growth factor GDF5. (494 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EPQ2	A0A1L8HUK7	A0A1L8EPQ2	A0A1L8HUK7	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.713
A0A1L8EPQ2	Bmp2.L	A0A1L8EPQ2	A0A1L8G5P4	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.639
A0A1L8EPQ2	Bmp6.S	A0A1L8EPQ2	A0A1L8FS81	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.500
A0A1L8EPQ2	bmp10	A0A1L8EPQ2	A0A1L8GSA3	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.600
A0A1L8EPQ2	bmp10-2	A0A1L8EPQ2	A0A1L8H1G9	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.600
A0A1L8EPQ2	bmp2	A0A1L8EPQ2	A0A1L8G1N2	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.639
A0A1L8EPQ2	bmp4	A0A1L8EPQ2	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.639
A0A1L8EPQ2	bmp4-2	A0A1L8EPQ2	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.639
A0A1L8EPQ2	bmp6	A0A1L8EPQ2	A0A1L8FXW8	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.500
A0A1L8EPQ2	gdf2	A0A1L8EPQ2	A0A1L8FKQ2	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.600
A0A1L8EPQ2	smad7	A0A1L8EPQ2	A0A1L8HS28	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.495
A0A1L8EPQ2	smad7-2	A0A1L8EPQ2	O57459	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.495
A0A1L8EPQ9	A0A1L8HUK7	A0A1L8EPQ9	A0A1L8HUK7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.641
A0A1L8EPQ9	Bmp2.L	A0A1L8EPQ9	A0A1L8G5P4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.639
A0A1L8EPQ9	Bmp6.S	A0A1L8EPQ9	A0A1L8FS81	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.500
A0A1L8EPQ9	bmp10	A0A1L8EPQ9	A0A1L8GSA3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.600
A0A1L8EPQ9	bmp10-2	A0A1L8EPQ9	A0A1L8H1G9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.600
A0A1L8EPQ9	bmp2	A0A1L8EPQ9	A0A1L8G1N2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.639
A0A1L8EPQ9	bmp4	A0A1L8EPQ9	B7ZPR8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.639
A0A1L8EPQ9	bmp4-2	A0A1L8EPQ9	Q91703	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.639