(18 nodes) Cell surface receptor signaling pathway involved in heart development network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	galnt11	Polypeptide N-acetylgalactosaminyltransferase. (603 aa)
	Galnt11.L	Polypeptide N-acetylgalactosaminyltransferase. (643 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	msx1	Homeobox domain-containing protein. (275 aa)
	mks1	Mks1 protein. (561 aa)
	msx1-2	LOC100125666 protein. (273 aa)
	nog	Noggin; Belongs to the noggin family. (222 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	A0A1L8EP11	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
	notch1	Uncharacterized protein. (2521 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	A0A1L8F3L0	Uncharacterized protein. (2377 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	Acvr1.L	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (624 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (675 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EP11	tgfb1	A0A1L8EP11	A0A1L8F3Y7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
A0A1L8EP11	tgfb1-2	A0A1L8EP11	A0A1L8F936	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
A0A1L8F3L0	Jag1.L	A0A1L8F3L0	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.988
A0A1L8F3L0	ctnnb1	A0A1L8F3L0	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.592
A0A1L8F3L0	dll4	A0A1L8F3L0	A0A1L8FB19	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.986
A0A1L8F3L0	jag1	A0A1L8F3L0	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.988
Acvr1.L	ctnnb1	A0A1L8EW46	Q63ZT4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Beta-catenin protein.	0.436
Acvr1.L	nog	A0A1L8EW46	B7ZQ39	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Belongs to the noggin family.	0.413
Acvr1.L	tgfb1	A0A1L8EW46	A0A1L8F3Y7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
Acvr1.L	tgfb1-2	A0A1L8EW46	A0A1L8F936	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
Jag1.L	A0A1L8F3L0	A0A1L8G723	A0A1L8F3L0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.988
Jag1.L	Notch1.S	A0A1L8G723	A0A1L8F124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.996
Jag1.L	ctnnb1	A0A1L8G723	Q63ZT4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-catenin protein.	0.629
Jag1.L	dll4	A0A1L8G723	A0A1L8FB19	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.511
Jag1.L	jag1	A0A1L8G723	A0A1L8G0P5	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.900
Jag1.L	notch1	A0A1L8G723	A0A1L8F627	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.996
Jag1.L	tgfb1	A0A1L8G723	A0A1L8F3Y7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.524
Jag1.L	tgfb1-2	A0A1L8G723	A0A1L8F936	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.524
Notch1.S	Jag1.L	A0A1L8F124	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.996
Notch1.S	ctnnb1	A0A1L8F124	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.936