(22 nodes) Lens fiber cell differentiation network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tbc1d20.1	Rab-GAP TBC domain-containing protein. (387 aa)
	tbc1d20.1-2	MGC52691 protein. (412 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	G50	Uncharacterized protein. (980 aa)
	Epha2.L	Uncharacterized protein. (948 aa)
	Bfsp2.S	IF rod domain-containing protein; Belongs to the intermediate filament family. (404 aa)
	Bfsp2.L	IF rod domain-containing protein; Belongs to the intermediate filament family. (402 aa)
	Tbc1d20.2.L	Rab-GAP TBC domain-containing protein. (388 aa)
	Bfsp1.L	IF rod domain-containing protein; Belongs to the intermediate filament family. (647 aa)
	A0A1L8GA38	c-SKI_SMAD_bind domain-containing protein. (643 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	A0A1L8HG68	FERM domain-containing protein. (638 aa)
	Nf2.S	FERM domain-containing protein. (584 aa)
	Fzr1.L	WD_REPEATS_REGION domain-containing protein. (251 aa)
	A0A1L8HVW6	WD_REPEATS_REGION domain-containing protein. (218 aa)
	Tdrd7.L	Uncharacterized protein. (1089 aa)
	Nf2.L	FERM domain-containing protein. (583 aa)
	A0A310TNS6	c-SKI_SMAD_bind domain-containing protein. (628 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HG68	Nf2.L	A0A1L8HG68	A0A1L8HZV7	FERM domain-containing protein.	FERM domain-containing protein.	0.903
A0A1L8HG68	Nf2.S	A0A1L8HG68	A0A1L8HPZ9	FERM domain-containing protein.	FERM domain-containing protein.	0.903
Atf4.L	Atf4.S	A0A1L8GNR5	A0A1L8GGY6	BZIP domain-containing protein.	BZIP domain-containing protein.	0.900
Atf4.S	Atf4.L	A0A1L8GGY6	A0A1L8GNR5	BZIP domain-containing protein.	BZIP domain-containing protein.	0.900
Bfsp1.L	Bfsp2.L	A0A1L8G725	A0A1L8FWK4	IF rod domain-containing protein; Belongs to the intermediate filament family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.963
Bfsp1.L	Bfsp2.S	A0A1L8G725	A0A1L8FRK6	IF rod domain-containing protein; Belongs to the intermediate filament family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.963
Bfsp1.L	Tdrd7.L	A0A1L8G725	A0A1L8HX47	IF rod domain-containing protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.457
Bfsp2.L	Bfsp1.L	A0A1L8FWK4	A0A1L8G725	IF rod domain-containing protein; Belongs to the intermediate filament family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.963
Bfsp2.S	Bfsp1.L	A0A1L8FRK6	A0A1L8G725	IF rod domain-containing protein; Belongs to the intermediate filament family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.963
Nf2.L	A0A1L8HG68	A0A1L8HZV7	A0A1L8HG68	FERM domain-containing protein.	FERM domain-containing protein.	0.903
Nf2.L	Nf2.S	A0A1L8HZV7	A0A1L8HPZ9	FERM domain-containing protein.	FERM domain-containing protein.	0.900
Nf2.S	A0A1L8HG68	A0A1L8HPZ9	A0A1L8HG68	FERM domain-containing protein.	FERM domain-containing protein.	0.903
Nf2.S	Nf2.L	A0A1L8HPZ9	A0A1L8HZV7	FERM domain-containing protein.	FERM domain-containing protein.	0.900
Tdrd7.L	Bfsp1.L	A0A1L8HX47	A0A1L8G725	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.457
tgfb1	tgfb1-2	A0A1L8F3Y7	A0A1L8F936	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.900
tgfb1-2	tgfb1	A0A1L8F936	A0A1L8F3Y7	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.900