(70 nodes) Negative regulation of ERK1 and ERK2 cascade network (Xenopus laevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	phb	Prohibitin. (272 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (430 aa)
	gper1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	Flcn.S	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	A0A1L8ETC6	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
	gper1-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	synj2bp	PDZ domain-containing protein. (143 aa)
	Spred1.S	WH1 domain-containing protein. (223 aa)
	dusp9	Uncharacterized protein. (486 aa)
	spry3	Uncharacterized protein. (289 aa)
	spred3	Uncharacterized protein. (422 aa)
	spry3-2	Uncharacterized protein. (286 aa)
	spred3-2	Uncharacterized protein. (423 aa)
	Spred1.L	Uncharacterized protein. (405 aa)
	A0A1L8FDB0	Mothers against decapentaplegic homolog. (514 aa)
	Errfi1.S	Inhibitor_Mig-6 domain-containing protein. (404 aa)
	lyn	Tyrosine-protein kinase. (508 aa)
	A0A1L8FYE8	Tyrosine-protein phosphatase non-receptor type. (462 aa)
	lyn-2	Tyrosine-protein kinase. (508 aa)
	A0A1L8G071	UPAR/Ly6 domain-containing protein. (125 aa)
	lypd2	UPAR/Ly6 domain-containing protein. (124 aa)
	psca	UPAR/Ly6 domain-containing protein. (132 aa)
	A0A1L8G0B7	Tfp5. (122 aa)
	A0A1L8G129	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	atf3	BZIP domain-containing protein. (182 aa)
	adipoq	C1q domain-containing protein. (233 aa)
	A0A1L8G5B3	PID domain-containing protein. (180 aa)
	emilin1	Uncharacterized protein. (1089 aa)
	A0A1L8G644	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	A0A1L8GAC5	Uncharacterized protein. (290 aa)
	emilin1-2	Uncharacterized protein. (1098 aa)
	A0A1L8GCV6	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (423 aa)
	A0A1L8GGJ1	Uncharacterized protein. (1173 aa)
	A0A1L8GJT0	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (424 aa)
	vrk3	Protein kinase domain-containing protein. (511 aa)
	A0A1L8GN98	Uncharacterized protein. (1290 aa)
	tlr9	TIR domain-containing protein; Belongs to the Toll-like receptor family. (830 aa)
	A0A1L8GQI3	NTR domain-containing protein. (214 aa)
	A0A1L8GUJ2	Uncharacterized protein. (664 aa)
	spry4	Uncharacterized protein. (297 aa)
	Fbln1.L	Uncharacterized protein. (534 aa)
	A0A1L8GW21	Uncharacterized protein. (116 aa)
	A0A1L8GW92	Uncharacterized protein. (126 aa)
	tnip1	CC2-LZ domain-containing protein. (634 aa)
	pin1-2	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	spry4-2	Uncharacterized protein. (297 aa)
	ptprr	Uncharacterized protein. (666 aa)
	A0A1L8H1C0	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (190 aa)
	spry2	Uncharacterized protein. (307 aa)
	A0A1L8HJ50	C1q domain-containing protein. (236 aa)
	A0A1L8HPW4	Uncharacterized protein. (216 aa)
	A0A1L8HRQ5	PID domain-containing protein. (784 aa)
	A0A1L8HRY9	Mothers against decapentaplegic homolog. (549 aa)
	spry1	Uncharacterized protein. (342 aa)
	tnip3	CC2-LZ domain-containing protein. (279 aa)
	lif	Uncharacterized protein. (216 aa)
	A0A1L8I2I6	PID domain-containing protein. (751 aa)
	A0A1L8I2V3	Mothers against decapentaplegic homolog. (510 aa)
	spry1-2	Sprouty 1. (319 aa)
	tnip1-2	LOC495827 protein. (637 aa)
	atf3-2	MGC81814 protein. (181 aa)
	ezr	MGC82058 protein. (582 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (468 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	synj2bp-2	Outer membrane protein 25. (145 aa)
	adipoq-2	MGC84292 protein. (235 aa)
	ptpn1-2	Tyrosine-protein phosphatase non-receptor type. (428 aa)
	errfi1	MGC68521 protein. (401 aa)
	phb-2	Prohibitin. (272 aa)
	spry2-2	LOC398313 protein. (314 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ETC6	ptprr	A0A1L8ETC6	A0A1L8GYK8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.917
A0A1L8ETC6	vrk3	A0A1L8ETC6	A0A1L8GK79	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.923
A0A1L8FYE8	lyn	A0A1L8FYE8	A0A1L8FT48	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.424
A0A1L8FYE8	lyn-2	A0A1L8FYE8	A0A1L8FZ11	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.424
A0A1L8G129	vrk3	A0A1L8G129	A0A1L8GK79	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.440
A0A1L8G644	vrk3	A0A1L8G644	A0A1L8GK79	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.440
A0A1L8GCV6	vrk3	A0A1L8GCV6	A0A1L8GK79	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.440
A0A1L8GGJ1	lyn	A0A1L8GGJ1	A0A1L8FT48	Uncharacterized protein.	Tyrosine-protein kinase.	0.577
A0A1L8GGJ1	lyn-2	A0A1L8GGJ1	A0A1L8FZ11	Uncharacterized protein.	Tyrosine-protein kinase.	0.577
A0A1L8GGJ1	tlr9	A0A1L8GGJ1	A0A1L8GPC9	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.422
A0A1L8GJT0	vrk3	A0A1L8GJT0	A0A1L8GK79	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.440
A0A1L8GN98	lyn	A0A1L8GN98	A0A1L8FT48	Uncharacterized protein.	Tyrosine-protein kinase.	0.577
A0A1L8GN98	lyn-2	A0A1L8GN98	A0A1L8FZ11	Uncharacterized protein.	Tyrosine-protein kinase.	0.577
A0A1L8GN98	tlr9	A0A1L8GN98	A0A1L8GPC9	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.422
A0A1L8H1C0	vrk3	A0A1L8H1C0	A0A1L8GK79	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.798
A0A1L8HPW4	lif	A0A1L8HPW4	A0A1L8HZU9	Uncharacterized protein.	Uncharacterized protein.	0.901
Errfi1.S	Spred1.L	A0A1L8FGC7	A0A1L8FAS2	Inhibitor_Mig-6 domain-containing protein.	Uncharacterized protein.	0.477
Spred1.L	Errfi1.S	A0A1L8FAS2	A0A1L8FGC7	Uncharacterized protein.	Inhibitor_Mig-6 domain-containing protein.	0.477
Spred1.L	errfi1	A0A1L8FAS2	Q6PA50	Uncharacterized protein.	MGC68521 protein.	0.477
adipoq	adipoq-2	A0A1L8G4R9	Q6GLS9	C1q domain-containing protein.	MGC84292 protein.	0.942