(16 nodes) co-SMAD binding network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mad2	Mothers against decapentaplegic homolog. (467 aa)
	smad6	Mothers against decapentaplegic homolog. (352 aa)
	smad6-2	Mothers against decapentaplegic homolog. (354 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	Pax10b	Paired box 10b. (281 aa)
	cited1	Uncharacterized protein. (142 aa)
	Foxh1.2.L	Fork-head domain-containing protein. (344 aa)
	Pax10a	Homeobox domain-containing protein. (281 aa)
	foxh1	Fork-head domain-containing protein. (518 aa)
	pax6	Uncharacterized protein. (467 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	usp9x	USP domain-containing protein; Belongs to the peptidase C19 family. (2545 aa)
	usp9x-2	USP domain-containing protein; Belongs to the peptidase C19 family. (2545 aa)
	A0A1L8HS33	Mothers against decapentaplegic homolog. (427 aa)
	A0A1L8HUK7	Mothers against decapentaplegic homolog. (422 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HS33	A0A1L8HUK7	A0A1L8HS33	A0A1L8HUK7	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.617
A0A1L8HS33	Foxh1.2.L	A0A1L8HS33	A0A1L8G0L6	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.697
A0A1L8HS33	foxh1	A0A1L8HS33	A0A1L8G0C8	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.697
A0A1L8HS33	smad6	A0A1L8HS33	A1L3N0	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.411
A0A1L8HS33	smad6-2	A0A1L8HS33	O57475	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.411
A0A1L8HUK7	A0A1L8HS33	A0A1L8HUK7	A0A1L8HS33	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.617
A0A1L8HUK7	Foxh1.2.L	A0A1L8HUK7	A0A1L8G0L6	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.535
A0A1L8HUK7	Mad2	A0A1L8HUK7	A0A1L8I2V8	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.615
A0A1L8HUK7	Smad3	A0A1L8HUK7	A0A1L8GSA7	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.615
A0A1L8HUK7	foxh1	A0A1L8HUK7	A0A1L8G0C8	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.535
A0A1L8HUK7	smad3	A0A1L8HUK7	Q90YE5	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.615
A0A1L8HUK7	smad6	A0A1L8HUK7	A1L3N0	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.875
A0A1L8HUK7	smad6-2	A0A1L8HUK7	O57475	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.875
A0A1L8HUK7	usp9x	A0A1L8HUK7	A0A1L8H6G5	Mothers against decapentaplegic homolog.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.408
A0A1L8HUK7	usp9x-2	A0A1L8HUK7	A0A1L8HFA1	Mothers against decapentaplegic homolog.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.408
Foxh1.2.L	A0A1L8HS33	A0A1L8G0L6	A0A1L8HS33	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.697
Foxh1.2.L	A0A1L8HUK7	A0A1L8G0L6	A0A1L8HUK7	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.535
Foxh1.2.L	Mad2	A0A1L8G0L6	A0A1L8I2V8	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.697
Foxh1.2.L	Smad3	A0A1L8G0L6	A0A1L8GSA7	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.697
Foxh1.2.L	smad3	A0A1L8G0L6	Q90YE5	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.697