(42 nodes) R-SMAD binding network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pax10b	Paired box 10b. (281 aa)
	A0A1L8HRY9	Mothers against decapentaplegic homolog. (549 aa)
	A0A1L8HS33	Mothers against decapentaplegic homolog. (427 aa)
	A0A1L8HYA8	BZIP domain-containing protein. (436 aa)
	A0A1L8I2V3	Mothers against decapentaplegic homolog. (510 aa)
	Mad2	Mothers against decapentaplegic homolog. (467 aa)
	smad6	Mothers against decapentaplegic homolog. (352 aa)
	fos	BZIP domain-containing protein. (369 aa)
	smad6-2	Mothers against decapentaplegic homolog. (354 aa)
	DDX5	DDX5 protein; Belongs to the DEAD box helicase family. (608 aa)
	fos-2	MGC80305 protein. (368 aa)
	ranbp3-2	Ran binding protein 3. (516 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	ranbp3	RanBD1 domain-containing protein. (520 aa)
	pax6	Uncharacterized protein. (467 aa)
	Foxh1.2.L	Fork-head domain-containing protein. (344 aa)
	A0A1L8G0D5	Uncharacterized protein. (445 aa)
	foxh1	Fork-head domain-containing protein. (518 aa)
	A0A1L8G085	Uncharacterized protein. (394 aa)
	ldlrad4-2	Uncharacterized protein. (273 aa)
	A0A1L8FXL6	Uncharacterized protein. (1323 aa)
	ldlrad4	Uncharacterized protein. (273 aa)
	Drosha.S	Uncharacterized protein. (1308 aa)
	Ankrd1.L	ANK_REP_REGION domain-containing protein. (318 aa)
	Smurf1.L	E3 ubiquitin-protein ligase. (731 aa)
	Pax10a	Homeobox domain-containing protein. (281 aa)
	ankrd1	ANK_REP_REGION domain-containing protein. (317 aa)
	A0A1L8FDB0	Mothers against decapentaplegic homolog. (514 aa)
	Myocd.L	SAP domain-containing protein. (959 aa)
	Pmepa1.L	Uncharacterized protein. (285 aa)
	A0A1L8EPZ7	E3 ubiquitin-protein ligase. (729 aa)
	Ddx5.S	Uncharacterized protein; Belongs to the DEAD box helicase family. (655 aa)
	myocd	SAP domain-containing protein. (960 aa)
	pmepa1	Uncharacterized protein. (285 aa)
	ppm1a	PPM-type phosphatase domain-containing protein. (516 aa)
	A0A1L8HHH0	Uncharacterized protein. (128 aa)
	Rgcc.S	Uncharacterized protein. (162 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Men1.L	Uncharacterized protein. (675 aa)
	pax6-2	Uncharacterized protein. (467 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EPZ7	A0A1L8FDB0	A0A1L8EPZ7	A0A1L8FDB0	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.721
A0A1L8EPZ7	A0A1L8HRY9	A0A1L8EPZ7	A0A1L8HRY9	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.721
A0A1L8EPZ7	A0A1L8HS33	A0A1L8EPZ7	A0A1L8HS33	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.703
A0A1L8EPZ7	A0A1L8I2V3	A0A1L8EPZ7	A0A1L8I2V3	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.721
A0A1L8EPZ7	Mad2	A0A1L8EPZ7	A0A1L8I2V8	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.703
A0A1L8EPZ7	Smad3	A0A1L8EPZ7	A0A1L8GSA7	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.703
A0A1L8EPZ7	smad3	A0A1L8EPZ7	Q90YE5	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.703
A0A1L8EPZ7	smad6	A0A1L8EPZ7	A1L3N0	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.966
A0A1L8EPZ7	smad6-2	A0A1L8EPZ7	O57475	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.966
A0A1L8FDB0	A0A1L8EPZ7	A0A1L8FDB0	A0A1L8EPZ7	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.721
A0A1L8FDB0	A0A1L8HS33	A0A1L8FDB0	A0A1L8HS33	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.877
A0A1L8FDB0	A0A1L8HYA8	A0A1L8FDB0	A0A1L8HYA8	Mothers against decapentaplegic homolog.	BZIP domain-containing protein.	0.443
A0A1L8FDB0	Foxh1.2.L	A0A1L8FDB0	A0A1L8G0L6	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.673
A0A1L8FDB0	Jun.L	A0A1L8FDB0	A0A1L8GLZ4	Mothers against decapentaplegic homolog.	BZIP domain-containing protein; Belongs to the bZIP family.	0.443
A0A1L8FDB0	Mad2	A0A1L8FDB0	A0A1L8I2V8	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.877
A0A1L8FDB0	Men1.L	A0A1L8FDB0	A0A1L8GK26	Mothers against decapentaplegic homolog.	Uncharacterized protein.	0.658
A0A1L8FDB0	Smad3	A0A1L8FDB0	A0A1L8GSA7	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.877
A0A1L8FDB0	Smurf1.L	A0A1L8FDB0	A0A1L8EX82	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.721
A0A1L8FDB0	c-Jun	A0A1L8FDB0	Q9PVZ1	Mothers against decapentaplegic homolog.	C-Jun protein; Belongs to the bZIP family.	0.443
A0A1L8FDB0	foxh1	A0A1L8FDB0	A0A1L8G0C8	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.673