(52 nodes) Positive regulation of wound healing network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FKW5	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2533 aa)
	cldn1-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	fermt1-2	MGC53981 protein. (675 aa)
	anxa1.1-2	Annexin. (343 aa)
	anxa1.1	Annexin. (343 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (607 aa)
	fermt2-2	Plekhc1-prov protein. (687 aa)
	anxa1.3	Annexin. (363 aa)
	serpinf2-2	MGC86518 protein; Belongs to the serpin family. (705 aa)
	nfe2l2	MGC53355 protein. (591 aa)
	A0A310TVP4	F5/8 type C domain-containing protein. (87 aa)
	A0A1L8I199	BZIP domain-containing protein. (390 aa)
	A0A1L8HYC9	Annexin. (242 aa)
	A0A1L8HY95	Annexin. (338 aa)
	tbxa2r-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (371 aa)
	Hpse.L	Uncharacterized protein. (492 aa)
	A0A1L8HQW3	BZIP domain-containing protein. (433 aa)
	anxa1.2	Annexin. (338 aa)
	tbxa2r	G_PROTEIN_RECEP_F1_2 domain-containing protein. (371 aa)
	Cpb2.L	Peptidase_M14 domain-containing protein. (419 aa)
	Cldn4.L	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (591 aa)
	cpb2	Peptidase_M14 domain-containing protein. (421 aa)
	Serpine1.L	SERPIN domain-containing protein; Belongs to the serpin family. (403 aa)
	dmtn	HP domain-containing protein. (412 aa)
	Duox2.L	Uncharacterized protein. (1515 aa)
	A0A1L8H085	Uncharacterized protein. (1505 aa)
	ano6	Anoctamin. (909 aa)
	hbegf	EGF-like domain-containing protein. (196 aa)
	A0A1L8GT82	Uncharacterized protein. (1435 aa)
	A0A1L8GRT2	HP domain-containing protein. (365 aa)
	ddr2-2	Uncharacterized protein. (885 aa)
	F2.L	Uncharacterized protein; Belongs to the peptidase S1 family. (564 aa)
	ddr2	Uncharacterized protein. (873 aa)
	Enpp4.L	Uncharacterized protein. (452 aa)
	cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	fermt1	PH domain-containing protein. (675 aa)
	A0A1L8FZ82	SEC7 domain-containing protein. (1771 aa)
	A0A1L8FZ76	Uncharacterized protein. (404 aa)
	rreb1-2	Uncharacterized protein. (1686 aa)
	A0A1L8FT76	SEC7 domain-containing protein. (1856 aa)
	rreb1	Uncharacterized protein. (1635 aa)
	St3gal4.L	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (393 aa)
	A0A1L8FFP6	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (310 aa)
	A0A1L8FFN1	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (347 aa)
	Thbs2.L	Uncharacterized protein. (1176 aa)
	A0A1L8F4B9	Uncharacterized protein. (1020 aa)
	ddr2l	Uncharacterized protein. (879 aa)
	fermt2	PH domain-containing protein. (687 aa)
	Apoh.L	Uncharacterized protein. (347 aa)
	Nfe2l2.S	BZIP domain-containing protein; Belongs to the bZIP family. (590 aa)
	A0A1L8EKE6	F5/8 type C domain-containing protein. (105 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F4B9	Serpine1.L	A0A1L8F4B9	A0A1L8H381	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.502
A0A1L8FFP6	St3gal4.L	A0A1L8FFP6	A0A1L8FL66	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.900
A0A1L8FKW5	A0A1L8HQW3	A0A1L8FKW5	A0A1L8HQW3	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	BZIP domain-containing protein.	0.422
A0A1L8FKW5	A0A1L8I199	A0A1L8FKW5	A0A1L8I199	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	BZIP domain-containing protein.	0.422
A0A1L8HQW3	A0A1L8FKW5	A0A1L8HQW3	A0A1L8FKW5	BZIP domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.422
A0A1L8I199	A0A1L8FKW5	A0A1L8I199	A0A1L8FKW5	BZIP domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.422
Apoh.L	Cpb2.L	A0A1L8EUY9	A0A1L8HHM0	Uncharacterized protein.	Peptidase_M14 domain-containing protein.	0.418
Apoh.L	F2.L	A0A1L8EUY9	A0A1L8GIR4	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.918
Apoh.L	cpb2	A0A1L8EUY9	A0A1L8H9N7	Uncharacterized protein.	Peptidase_M14 domain-containing protein.	0.418
Apoh.L	f2	A0A1L8EUY9	Q6DFJ5	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.918
Apoh.L	serpinf2	A0A1L8EUY9	A0A1L8HD88	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.682
Apoh.L	serpinf2-2	A0A1L8EUY9	Q66IN0	Uncharacterized protein.	MGC86518 protein; Belongs to the serpin family.	0.682
Cldn4.L	cldn1	A0A1L8HDJ7	A0A1L8GA96	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.808
Cldn4.L	cldn1-2	A0A1L8HDJ7	Q8AVG4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.809
Cpb2.L	Apoh.L	A0A1L8HHM0	A0A1L8EUY9	Peptidase_M14 domain-containing protein.	Uncharacterized protein.	0.418
Cpb2.L	F2.L	A0A1L8HHM0	A0A1L8GIR4	Peptidase_M14 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.653
Cpb2.L	Serpine1.L	A0A1L8HHM0	A0A1L8H381	Peptidase_M14 domain-containing protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.440
Cpb2.L	f2	A0A1L8HHM0	Q6DFJ5	Peptidase_M14 domain-containing protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.653
Cpb2.L	serpinf2	A0A1L8HHM0	A0A1L8HD88	Peptidase_M14 domain-containing protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.519
Cpb2.L	serpinf2-2	A0A1L8HHM0	Q66IN0	Peptidase_M14 domain-containing protein.	MGC86518 protein; Belongs to the serpin family.	0.519