(100 nodes) Extrinsic apoptotic signaling pathway network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bcl2l11-2	Uncharacterized protein. (194 aa)
	itpripl2-2	Mab-21 domain-containing protein. (502 aa)
	A0A1L8F002	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (163 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	mcl1	Uncharacterized protein. (277 aa)
	mllt11	WRNPLPNID domain-containing protein. (82 aa)
	Daxx.L	Daxx domain-containing protein. (911 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Siva1.L	Uncharacterized protein. (174 aa)
	Mcl1.L	Uncharacterized protein. (277 aa)
	mllt11-2	WRNPLPNID domain-containing protein. (79 aa)
	itprip	Mab-21 domain-containing protein. (542 aa)
	bag3	Uncharacterized protein. (527 aa)
	A0A1L8FDU4	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	fadd	Uncharacterized protein. (188 aa)
	pidd1	Uncharacterized protein. (909 aa)
	A0A1L8GJQ1	Uncharacterized protein. (151 aa)
	tradd	Death domain-containing protein. (303 aa)
	A0A1L8GKT2	Uncharacterized protein. (160 aa)
	A0A1L8GKT4	Uncharacterized protein. (194 aa)
	Faslg.L	TNF_2 domain-containing protein. (248 aa)
	dele1	Uncharacterized protein. (535 aa)
	bcl2l10	Uncharacterized protein. (174 aa)
	A0A1L8GUI6	Uncharacterized protein. (183 aa)
	dele1-2	Uncharacterized protein. (537 aa)
	ifng	Uncharacterized protein. (182 aa)
	bcl2l10-2	Uncharacterized protein. (174 aa)
	pdia3	Protein disulfide-isomerase. (500 aa)
	A0A1L8H3Q2	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (189 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	A0A1L8H656	Uncharacterized protein. (101 aa)
	ngf	NGF domain-containing protein; Belongs to the NGF-beta family. (242 aa)
	Sort1.S	Sortilin. (801 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	rnf41	RING-type domain-containing protein. (317 aa)
	A0A1L8HBT3	Uncharacterized protein. (28 aa)
	A0A1L8HBT4	Protein kinase domain-containing protein. (64 aa)
	A0A1L8HBY8	Protein kinase domain-containing protein. (298 aa)
	A0A1L8HDZ4	Uncharacterized protein. (101 aa)
	Ngf.L	NGF domain-containing protein; Belongs to the NGF-beta family. (232 aa)
	nf1	Uncharacterized protein. (2759 aa)
	A0A1L8HHP5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
	krt8.1	IF rod domain-containing protein; Belongs to the intermediate filament family. (512 aa)
	A0A1L8HKQ7	Uncharacterized protein. (925 aa)
	Bcl2l2.S	BH4_2 domain-containing protein. (188 aa)
	parp2	Poly [ADP-ribose] polymerase. (742 aa)
	Fgfr3.L	Fibroblast growth factor receptor. (821 aa)
	A0A1L8HTX4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (896 aa)
	parp2-2	Poly [ADP-ribose] polymerase. (680 aa)
	P2rx7.L	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (553 aa)
	A0A310TNS6	c-SKI_SMAD_bind domain-containing protein. (628 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	XALK4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	fadd-2	Fas-associating death domain-containing protein. (188 aa)
	rnf41-2	LOC495085 protein. (315 aa)
	bcl2l2	MGC80617 protein. (188 aa)
	ddx47	MGC81303 protein; Belongs to the DEAD box helicase family. (448 aa)
	casp10-2	MGC68465 protein; Belongs to the peptidase C14A family. (512 aa)
	pdia3-2	Protein disulfide-isomerase. (502 aa)
	krt8.1-2	Krt8 protein; Belongs to the intermediate filament family. (507 aa)
	bag3-2	Bag3-A protein. (597 aa)
	A0A1L8ELE2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (554 aa)
	A0A1L8ELY1	BH4_2 domain-containing protein. (219 aa)
	casp10	Uncharacterized protein; Belongs to the peptidase C14A family. (520 aa)
	itpripl2	Mab-21 domain-containing protein. (502 aa)
	A0A1L8ESL5	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (523 aa)
	A0A1L8ETC2	BH4_2 domain-containing protein. (212 aa)
	Casp8.L	Uncharacterized protein; Belongs to the peptidase C14A family. (500 aa)
	A0A1L8FE31	Uncharacterized protein. (332 aa)
	gsk3a	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)
	dedd2	DED domain-containing protein. (355 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	Itprip.L	Mab-21 domain-containing protein. (573 aa)
	Casp2.L	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	A0A1L8FII3	Uncharacterized protein. (314 aa)
	A0A1L8FN20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	Dedd2.L	DED domain-containing protein. (357 aa)
	inhba	TGF_BETA_2 domain-containing protein. (411 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	ripk1	Uncharacterized protein. (666 aa)
	rb1cc1	ATG11 domain-containing protein. (1573 aa)
	inhba-2	TGF_BETA_2 domain-containing protein. (411 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	A0A1L8FXS1	Uncharacterized protein. (581 aa)
	rb1cc1-2	ATG11 domain-containing protein. (1573 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	bcl2l11	Uncharacterized protein. (194 aa)
	A0A1L8G343	Uncharacterized protein. (1788 aa)
	bok	Uncharacterized protein. (214 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	Itgav.L	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1080 aa)
	A0A1L8G9R4	Uncharacterized protein. (1695 aa)
	A0A1L8GA38	c-SKI_SMAD_bind domain-containing protein. (643 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (204 aa)
	IL12A-2	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (267 aa)
	bok-2	Uncharacterized protein. (214 aa)
	A0A1L8GEH0	Uncharacterized protein. (193 aa)
	faslg	TNF_2 domain-containing protein. (246 aa)
	A0A1L8GGU4	Uncharacterized protein; Belongs to the DEAD box helicase family. (468 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELY1	A0A1L8F002	A0A1L8ELY1	A0A1L8F002	BH4_2 domain-containing protein.	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.	0.468
A0A1L8ELY1	A0A1L8FDU4	A0A1L8ELY1	A0A1L8FDU4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ELY1	A0A1L8FXP7	A0A1L8ELY1	A0A1L8FXP7	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.881
A0A1L8ELY1	A0A1L8GJQ1	A0A1L8ELY1	A0A1L8GJQ1	BH4_2 domain-containing protein.	Uncharacterized protein.	0.977
A0A1L8ELY1	Bax.L	A0A1L8ELY1	A0A1L8FH04	BH4_2 domain-containing protein.	Uncharacterized protein.	0.978
A0A1L8ELY1	Bcl2.S	A0A1L8ELY1	A0A1L8FSA4	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.885
A0A1L8ELY1	Casp2.L	A0A1L8ELY1	A0A1L8FIC4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ELY1	Casp8.L	A0A1L8ELY1	A0A1L8EWT3	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.479
A0A1L8ELY1	Daxx.L	A0A1L8ELY1	A0A1L8F8G2	BH4_2 domain-containing protein.	Daxx domain-containing protein.	0.569
A0A1L8ELY1	Mcl1.L	A0A1L8ELY1	A0A1L8FBT2	BH4_2 domain-containing protein.	Uncharacterized protein.	0.430
A0A1L8ELY1	Siva1.L	A0A1L8ELY1	A0A1L8FA40	BH4_2 domain-containing protein.	Uncharacterized protein.	0.468
A0A1L8ELY1	bcl2l10	A0A1L8ELY1	A0A1L8GSY4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.427
A0A1L8ELY1	bcl2l10-2	A0A1L8ELY1	A0A1L8H0I4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.427
A0A1L8ELY1	bcl2l11	A0A1L8ELY1	A0A1L8G1Y7	BH4_2 domain-containing protein.	Uncharacterized protein.	0.971
A0A1L8ELY1	bcl2l11-2	A0A1L8ELY1	A0A1L8G7D9	BH4_2 domain-containing protein.	Uncharacterized protein.	0.971
A0A1L8ELY1	casp10	A0A1L8ELY1	A0A1L8EPS7	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.479
A0A1L8ELY1	casp10-2	A0A1L8ELY1	Q6PAD9	BH4_2 domain-containing protein.	MGC68465 protein; Belongs to the peptidase C14A family.	0.479
A0A1L8ELY1	mcl1	A0A1L8ELY1	A0A1L8F4J2	BH4_2 domain-containing protein.	Uncharacterized protein.	0.430
A0A1L8ETC2	A0A1L8F002	A0A1L8ETC2	A0A1L8F002	BH4_2 domain-containing protein.	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.	0.944
A0A1L8ETC2	A0A1L8FDU4	A0A1L8ETC2	A0A1L8FDU4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500