(33 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FDU4	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	bag3-2	Bag3-A protein. (597 aa)
	bcl2l2	MGC80617 protein. (188 aa)
	fadd-2	Fas-associating death domain-containing protein. (188 aa)
	Bcl2l2.S	BH4_2 domain-containing protein. (188 aa)
	nf1	Uncharacterized protein. (2759 aa)
	A0A1L8HBY8	Protein kinase domain-containing protein. (298 aa)
	A0A1L8HBT4	Protein kinase domain-containing protein. (64 aa)
	A0A1L8HBT3	Uncharacterized protein. (28 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	bcl2l10-2	Uncharacterized protein. (174 aa)
	bcl2l10	Uncharacterized protein. (174 aa)
	A0A1L8GJQ1	Uncharacterized protein. (151 aa)
	fadd	Uncharacterized protein. (188 aa)
	bok-2	Uncharacterized protein. (214 aa)
	bcl2l11-2	Uncharacterized protein. (194 aa)
	bok	Uncharacterized protein. (214 aa)
	bcl2l11	Uncharacterized protein. (194 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	A0A1L8FN20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	Casp2.L	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	gsk3a	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)
	bag3	Uncharacterized protein. (527 aa)
	Mcl1.L	Uncharacterized protein. (277 aa)
	mcl1	Uncharacterized protein. (277 aa)
	Itgav.L	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1080 aa)
	A0A1L8ETC2	BH4_2 domain-containing protein. (212 aa)
	A0A1L8ESL5	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (523 aa)
	A0A1L8ELY1	BH4_2 domain-containing protein. (219 aa)
	A0A1L8ELE2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (554 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELY1	A0A1L8FDU4	A0A1L8ELY1	A0A1L8FDU4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ELY1	A0A1L8FXP7	A0A1L8ELY1	A0A1L8FXP7	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.881
A0A1L8ELY1	A0A1L8GJQ1	A0A1L8ELY1	A0A1L8GJQ1	BH4_2 domain-containing protein.	Uncharacterized protein.	0.977
A0A1L8ELY1	Bax.L	A0A1L8ELY1	A0A1L8FH04	BH4_2 domain-containing protein.	Uncharacterized protein.	0.978
A0A1L8ELY1	Bcl2.S	A0A1L8ELY1	A0A1L8FSA4	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.885
A0A1L8ELY1	Casp2.L	A0A1L8ELY1	A0A1L8FIC4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ELY1	Mcl1.L	A0A1L8ELY1	A0A1L8FBT2	BH4_2 domain-containing protein.	Uncharacterized protein.	0.430
A0A1L8ELY1	bcl2l10	A0A1L8ELY1	A0A1L8GSY4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.427
A0A1L8ELY1	bcl2l10-2	A0A1L8ELY1	A0A1L8H0I4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.427
A0A1L8ELY1	bcl2l11	A0A1L8ELY1	A0A1L8G1Y7	BH4_2 domain-containing protein.	Uncharacterized protein.	0.971
A0A1L8ELY1	bcl2l11-2	A0A1L8ELY1	A0A1L8G7D9	BH4_2 domain-containing protein.	Uncharacterized protein.	0.971
A0A1L8ELY1	mcl1	A0A1L8ELY1	A0A1L8F4J2	BH4_2 domain-containing protein.	Uncharacterized protein.	0.430
A0A1L8ETC2	A0A1L8FDU4	A0A1L8ETC2	A0A1L8FDU4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ETC2	A0A1L8FXP7	A0A1L8ETC2	A0A1L8FXP7	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.975
A0A1L8ETC2	A0A1L8GJQ1	A0A1L8ETC2	A0A1L8GJQ1	BH4_2 domain-containing protein.	Uncharacterized protein.	0.997
A0A1L8ETC2	Bax.L	A0A1L8ETC2	A0A1L8FH04	BH4_2 domain-containing protein.	Uncharacterized protein.	0.997
A0A1L8ETC2	Bcl2.S	A0A1L8ETC2	A0A1L8FSA4	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.975
A0A1L8ETC2	Casp2.L	A0A1L8ETC2	A0A1L8FIC4	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.500
A0A1L8ETC2	Mcl1.L	A0A1L8ETC2	A0A1L8FBT2	BH4_2 domain-containing protein.	Uncharacterized protein.	0.430
A0A1L8ETC2	bcl2l10	A0A1L8ETC2	A0A1L8GSY4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.427