82 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8HB68	G_PROTEIN_RECEP_F1_2 domain-containing protein. (329 aa)
	ptch1-2	Patched-1. (1418 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)
	creb1	Creb1-prov protein. (324 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	jup	LOC398496 protein. (737 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	golph3	LOC495055 protein. (288 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	larp1-2	MGC98945 protein. (1021 aa)
	ptrhd1	MGC154811 protein. (118 aa)
	H6D7E8_XENLA	Cytochrome P450 CYP1C; Belongs to the cytochrome P450 family. (522 aa)
	gammaxENaC-A	GammaxENaC-A protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (660 aa)
	Adcy1.S	AC_N domain-containing protein. (253 aa)
	ptger4-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	Efna5.L	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (185 aa)
	ptch1	SSD domain-containing protein. (1422 aa)
	Golph3.S	Uncharacterized protein. (290 aa)
	ptger4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (476 aa)
	Efna5.S	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (185 aa)
	A0A1L8HJV2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (329 aa)
	A0A1L8HHS4	Uncharacterized protein. (1302 aa)
	Gramd1c.L	VASt domain-containing protein. (647 aa)
	Adcy6.L	Uncharacterized protein. (1327 aa)
	A0A1L8H5M1	VASt domain-containing protein. (458 aa)
	A0A1L8H3E7	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	A0A1L8H2F9	Uncharacterized protein; Belongs to the AKAP95 family. (458 aa)
	A0A1L8H1D5	Uncharacterized protein. (1367 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	A0A1L8GZ67	Uncharacterized protein. (82 aa)
	A0A1L8GZ28	Uncharacterized protein. (106 aa)
	A0A1L8GZ14	Uncharacterized protein. (68 aa)
	A0A1L8GZ05	Uncharacterized protein. (121 aa)
	cftr-2	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	blm	Uncharacterized protein. (1368 aa)
	larp1	HTH La-type RNA-binding domain-containing protein. (1015 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	Podn.L	LRRNT domain-containing protein. (615 aa)
	A0A1L8GM16	Non-specific serine/threonine protein kinase. (551 aa)
	A0A1L8GLN6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	npas4	Uncharacterized protein. (723 aa)
	podn	LRRNT domain-containing protein. (597 aa)
	A0A1L8GFI4	Non-specific serine/threonine protein kinase. (551 aa)
	A0A1L8GFC9	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	A0A1L8GCR9	Uncharacterized protein. (718 aa)
	adcy3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	xrn1-2	5'-3' exoribonuclease 1. (1700 aa)
	cyp1b1-2	Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	xrn1	Uncharacterized protein. (1727 aa)
	cyp1b1	Uncharacterized protein; Belongs to the cytochrome P450 family. (553 aa)
	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	tp53inp1	Uncharacterized protein. (237 aa)
	cyp7a1	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	Spidr.L	Uncharacterized protein. (866 aa)
	A0A1L8FY60	Uncharacterized protein. (179 aa)
	A0A1L8FY59	Uncharacterized protein. (225 aa)
	adcy1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
	adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	Tp53inp1.S	Uncharacterized protein. (237 aa)
	Cyp7a1.S	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	Gramd1a.L	VASt domain-containing protein. (688 aa)
	A0A1L8FKZ8	VASt domain-containing protein. (748 aa)
	gramd1a	VASt domain-containing protein. (635 aa)
	A0A1L8FFK4	VASt domain-containing protein. (679 aa)
	A0A1L8FFK0	Uncharacterized protein. (89 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	ptger2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (370 aa)
	aifm1	Uncharacterized protein. (637 aa)
	Ptger2.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (371 aa)
	Scnn1b.L	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (647 aa)
	A0A1L8EX51	Uncharacterized protein. (327 aa)
	A0A1L8EVB6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	recql5	Uncharacterized protein. (1090 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Scnn1g.S	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (673 aa)
	Scnn1b.S	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	A0A1L8ENZ6	SSD domain-containing protein. (946 aa)
	A0A1L8ENI2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	Jup.S	Uncharacterized protein. (791 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI2	A0A1L8G048	A0A1L8ENI2	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8ENI2	A0A1L8G5C7	A0A1L8ENI2	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8ENI2	adcy1	A0A1L8ENI2	A0A1L8FWP0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.461
A0A1L8ENI2	adcy3	A0A1L8ENI2	A0A1L8GC45	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8ENI2	adcy8	A0A1L8ENI2	A0A1L8FTY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8ENI2	cftr	A0A1L8ENI2	A0A1L8GU84	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.508
A0A1L8ENI2	cftr-2	A0A1L8ENI2	A0A1L8GYY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.508
A0A1L8ENI2	ptrhd1	A0A1L8ENI2	Q05AU7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	MGC154811 protein.	0.402
A0A1L8ENZ6	Smo.L	A0A1L8ENZ6	A0A1L8GZN4	SSD domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.874
A0A1L8ENZ6	Smo.S	A0A1L8ENZ6	A0A1L8GTP2	SSD domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.874
A0A1L8EVB6	A0A1L8G048	A0A1L8EVB6	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8EVB6	A0A1L8G5C7	A0A1L8EVB6	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8EVB6	adcy1	A0A1L8EVB6	A0A1L8FWP0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.460
A0A1L8EVB6	adcy3	A0A1L8EVB6	A0A1L8GC45	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.423
A0A1L8EVB6	adcy8	A0A1L8EVB6	A0A1L8FTY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8EVB6	cftr	A0A1L8EVB6	A0A1L8GU84	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.508
A0A1L8EVB6	cftr-2	A0A1L8EVB6	A0A1L8GYY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.508
A0A1L8EVB6	ptrhd1	A0A1L8EVB6	Q05AU7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	MGC154811 protein.	0.402
A0A1L8EX51	ctnnb1	A0A1L8EX51	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.415
A0A1L8EX51	ctnnb1-2	A0A1L8EX51	Q7ZX35	Uncharacterized protein.	Ctnnb1-prov protein.	0.415