72 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nf1.S	Uncharacterized protein. (2774 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	sostdc1-2	Wise-A. (213 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	fgf7-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	trpc4ap	MGC130977 protein. (772 aa)
	X-Delta-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	XALK4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	kdf1-2	LOC100137694 protein. (362 aa)
	fst-2	Uncharacterized protein. (341 aa)
	zdhhc21-2	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	Pias4.L	Uncharacterized protein. (544 aa)
	fst	Uncharacterized protein. (339 aa)
	zdhhc21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (338 aa)
	Pias4.S	Uncharacterized protein. (543 aa)
	Intu.S	PDZ domain-containing protein. (951 aa)
	hoxc13-2	Homeobox domain-containing protein. (307 aa)
	A0A1L8HHP5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
	Edar.L	Uncharacterized protein. (453 aa)
	nf1	Uncharacterized protein. (2759 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	Foxn1.L	Fork-head domain-containing protein. (667 aa)
	hoxc13	Homeobox domain-containing protein. (306 aa)
	edar	Uncharacterized protein. (453 aa)
	A0A1L8H827	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa)
	kdf1	Uncharacterized protein. (347 aa)
	Foxn1.S	Fork-head domain-containing protein. (646 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	gorab-2	Uncharacterized protein. (365 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	gorab	Uncharacterized protein. (165 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	tp63-2	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	sos1	Uncharacterized protein. (1325 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	A0A1L8FYS5	GATA-type domain-containing protein. (466 aa)
	foxq1-2	Fork-head domain-containing protein. (433 aa)
	inhba-2	TGF_BETA_2 domain-containing protein. (411 aa)
	sostdc1	CTCK domain-containing protein. (213 aa)
	nom1	MI domain-containing protein. (868 aa)
	A0A1L8FTZ8	Uncharacterized protein. (136 aa)
	A0A1L8FT04	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1143 aa)
	gata6	Uncharacterized protein. (502 aa)
	foxq1	Fork-head domain-containing protein. (437 aa)
	inhba	TGF_BETA_2 domain-containing protein. (411 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	tmem79-2	Uncharacterized protein. (518 aa)
	Sav1.L	Uncharacterized protein. (388 aa)
	ercc2	Helicase ATP-binding domain-containing protein. (736 aa)
	Nsdhl.L	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (345 aa)
	A0A1L8F6W9	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (360 aa)
	nsdhl	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (345 aa)
	A0A1L8F2D9	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (357 aa)
	A0A1L8F0V0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (650 aa)
	sav1	Uncharacterized protein. (384 aa)
	A0A1L8EXI6	Phospholipase A(2). (161 aa)
	igfbp5-2	Uncharacterized protein. (265 aa)
	Dlx3.L	Homeobox domain-containing protein. (277 aa)
	A0A1L8EQC9	Phospholipase A(2). (161 aa)
	dlx3	Homeobox domain-containing protein. (274 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F2D9	A0A1L8F6W9	A0A1L8F2D9	A0A1L8F6W9	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.900
A0A1L8F2D9	Edar.L	A0A1L8F2D9	A0A1L8HGT2	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.991
A0A1L8F2D9	edar	A0A1L8F2D9	A0A1L8H8R1	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.991
A0A1L8F6W9	A0A1L8F2D9	A0A1L8F6W9	A0A1L8F2D9	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.900
A0A1L8F6W9	Edar.L	A0A1L8F6W9	A0A1L8HGT2	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.979
A0A1L8F6W9	edar	A0A1L8F6W9	A0A1L8H8R1	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.979
A0A1L8FT04	ctnnb1	A0A1L8FT04	Q63ZT4	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Beta-catenin protein.	0.493
A0A1L8FT04	ctnnb1-2	A0A1L8FT04	Q7ZX35	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Ctnnb1-prov protein.	0.493
A0A1L8FT04	hoxc13	A0A1L8FT04	A0A1L8HAD3	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Homeobox domain-containing protein.	0.476
A0A1L8FT04	hoxc13-2	A0A1L8FT04	A0A1L8HIH2	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Homeobox domain-containing protein.	0.476
A0A1L8HHP5	XALK4	A0A1L8HHP5	B7ZRX3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.900
A0A1L8HHP5	fst	A0A1L8HHP5	A0A1L8HRM9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.409
A0A1L8HHP5	fst-2	A0A1L8HHP5	A0A1L8I2C7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.409
A0A1L8HHP5	inhba	A0A1L8HHP5	A0A1L8FRS5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	TGF_BETA_2 domain-containing protein.	0.993
A0A1L8HHP5	inhba-2	A0A1L8HHP5	A0A1L8FWM6	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	TGF_BETA_2 domain-containing protein.	0.993
A0A1L8HHP5	tgfb2	A0A1L8HHP5	A0A1L8G134	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.416
A0A1L8HHP5	tgfb2-2	A0A1L8HHP5	A0A1L8G6B2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.416
Edar.L	A0A1L8F2D9	A0A1L8HGT2	A0A1L8F2D9	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.991
Edar.L	A0A1L8F6W9	A0A1L8HGT2	A0A1L8F6W9	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.979
Edar.L	edar	A0A1L8HGT2	A0A1L8H8R1	Uncharacterized protein.	Uncharacterized protein.	0.900