(35 nodes) Negative regulation of cold-induced thermogenesis network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nr1h2	Uncharacterized protein. (438 aa)
	Flcn.S	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	A0A1L8EKN4	Uncharacterized protein. (522 aa)
	stk11-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	pgam5	Uncharacterized protein. (279 aa)
	Npr3.L	ANF_receptor domain-containing protein. (507 aa)
	Abhd6.S	AB hydrolase-1 domain-containing protein. (337 aa)
	acot13	LOC100137631 protein. (141 aa)
	znf423	Zinc finger protein 423. (1289 aa)
	adipoq-2	MGC84292 protein. (235 aa)
	ip6k1-2	Kinase; Belongs to the inositol phosphokinase (IPK) family. (412 aa)
	ddit3-2	Transcription factor GADD153. (211 aa)
	npr3	ANF_receptor domain-containing protein. (507 aa)
	Pgam5.S	Uncharacterized protein. (275 aa)
	stk11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	Hoxc10.L	Homeobox domain-containing protein. (351 aa)
	A0A1L8HGR1	Uncharacterized protein. (564 aa)
	il18r1	Uncharacterized protein. (558 aa)
	adamts5-2	Peptidase M12B domain-containing protein. (910 aa)
	A0A1L8HA71	Homeobox domain-containing protein. (91 aa)
	ddit3	Uncharacterized protein. (207 aa)
	rb1	Uncharacterized protein. (899 aa)
	adamts5	Peptidase M12B domain-containing protein. (911 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	ip6k1	Kinase; Belongs to the inositol phosphokinase (IPK) family. (177 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	A0A1L8GEK7	Uncharacterized protein. (955 aa)
	A0A1L8GE63	Uncharacterized protein. (79 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	lama4	Uncharacterized protein. (1915 aa)
	adipoq	C1q domain-containing protein. (233 aa)
	A0A1L8G2U4	Uncharacterized protein. (1736 aa)
	Nr1h2.L	Uncharacterized protein. (441 aa)
	Nr1d1.L	Uncharacterized protein. (671 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HGR1	il18r1	A0A1L8HGR1	A0A1L8HGP1	Uncharacterized protein.	Uncharacterized protein.	0.904
Atf4.L	Atf4.S	A0A1L8GNR5	A0A1L8GGY6	BZIP domain-containing protein.	BZIP domain-containing protein.	0.900
Atf4.L	ddit3	A0A1L8GNR5	A0A1L8H9T2	BZIP domain-containing protein.	Uncharacterized protein.	0.987
Atf4.L	ddit3-2	A0A1L8GNR5	Q7T2S7	BZIP domain-containing protein.	Transcription factor GADD153.	0.987
Atf4.S	Atf4.L	A0A1L8GGY6	A0A1L8GNR5	BZIP domain-containing protein.	BZIP domain-containing protein.	0.900
Atf4.S	ddit3	A0A1L8GGY6	A0A1L8H9T2	BZIP domain-containing protein.	Uncharacterized protein.	0.987
Atf4.S	ddit3-2	A0A1L8GGY6	Q7T2S7	BZIP domain-containing protein.	Transcription factor GADD153.	0.987
Flcn.S	stk11	A0A1L8EQZ5	A0A1L8HNA4	UDENN FLCN/SMCR8-type domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.560
Flcn.S	stk11-2	A0A1L8EQZ5	A0A1L8HWM5	UDENN FLCN/SMCR8-type domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.560
Pgam5.S	pgam5	A0A1L8HQG9	A0A1L8I0P9	Uncharacterized protein.	Uncharacterized protein.	0.900
adipoq	adipoq-2	A0A1L8G4R9	Q6GLS9	C1q domain-containing protein.	MGC84292 protein.	0.942
adipoq-2	adipoq	Q6GLS9	A0A1L8G4R9	MGC84292 protein.	C1q domain-containing protein.	0.942
ddit3	Atf4.L	A0A1L8H9T2	A0A1L8GNR5	Uncharacterized protein.	BZIP domain-containing protein.	0.987
ddit3	Atf4.S	A0A1L8H9T2	A0A1L8GGY6	Uncharacterized protein.	BZIP domain-containing protein.	0.987
ddit3	ddit3-2	A0A1L8H9T2	Q7T2S7	Uncharacterized protein.	Transcription factor GADD153.	0.901
ddit3-2	Atf4.L	Q7T2S7	A0A1L8GNR5	Transcription factor GADD153.	BZIP domain-containing protein.	0.987
ddit3-2	Atf4.S	Q7T2S7	A0A1L8GGY6	Transcription factor GADD153.	BZIP domain-containing protein.	0.987
ddit3-2	ddit3	Q7T2S7	A0A1L8H9T2	Transcription factor GADD153.	Uncharacterized protein.	0.901
il18r1	A0A1L8HGR1	A0A1L8HGP1	A0A1L8HGR1	Uncharacterized protein.	Uncharacterized protein.	0.904
ip6k1	ip6k1-2	A0A1L8GHA3	Q6GQ51	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.901