(53 nodes) Regulation of synaptic vesicle exocytosis network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8HBW6	Uncharacterized protein. (1186 aa)
	Git1	Uncharacterized protein. (737 aa)
	cask	Uncharacterized protein; Belongs to the MAGUK family. (920 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (412 aa)
	A0A1L8HI82	Anion exchange protein. (1109 aa)
	gipc3	PDZ domain-containing protein. (338 aa)
	A0A1L8HNU7	Uncharacterized protein. (1127 aa)
	apba1	Uncharacterized protein. (826 aa)
	syt4	Uncharacterized protein. (424 aa)
	A0A1L8HW37	PDZ domain-containing protein. (337 aa)
	apba1-2	Uncharacterized protein. (820 aa)
	A0A1L8HYF0	Uncharacterized protein. (1124 aa)
	P2rx7.L	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (553 aa)
	Adcy1.S	AC_N domain-containing protein. (253 aa)
	fmr1-A	Fragile X mental retardation 1. (564 aa)
	gipc2	GIPC protein. (331 aa)
	snapin	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (122 aa)
	cask-2	Cask-prov protein; Belongs to the MAGUK family. (920 aa)
	syt4-2	MGC84370 protein. (424 aa)
	git2	MGC80878 protein. (759 aa)
	gipc1	Developmental regulator. (331 aa)
	rap1a	MGC80662 protein. (185 aa)
	A0A1L8ES30	C2 domain-containing protein. (269 aa)
	A0A1L8ENZ7	SH3 domain-containing protein. (520 aa)
	rab3gap1	Uncharacterized protein. (980 aa)
	A0A1L8EL18	C2 domain-containing protein. (271 aa)
	Rab3gap1.L	Uncharacterized protein. (978 aa)
	A0A1L8EVV0	SH3 domain-containing protein. (520 aa)
	fmr1	Uncharacterized protein. (564 aa)
	A0A1L8F494	Pep3_Vps18 domain-containing protein. (599 aa)
	A0A1L8F661	Uncharacterized protein. (224 aa)
	Drd2.S	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	Drd2.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (438 aa)
	A0A1L8FMG2	Uncharacterized protein. (446 aa)
	A0A1L8FQC4	Uncharacterized protein. (699 aa)
	A0A1L8FUT2	Uncharacterized protein. (754 aa)
	adcy1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
	Dtnbp1.L	Uncharacterized protein. (317 aa)
	stxbp5	Uncharacterized protein. (1152 aa)
	Prepl	Uncharacterized protein. (707 aa)
	stxbp5-2	Uncharacterized protein. (1146 aa)
	A0A1L8GLP7	PDZ domain-containing protein. (331 aa)
	chrm2	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (467 aa)
	braf	Uncharacterized protein. (802 aa)
	A0A1L8GT65	Uncharacterized protein. (459 aa)
	rap1b	Uncharacterized protein. (184 aa)
	A0A1L8GYI4	Uncharacterized protein. (215 aa)
	lrrk2	Uncharacterized protein. (2514 aa)
	Chrna5.L	Uncharacterized protein. (416 aa)
	A0A1L8H4T5	Uncharacterized protein. (729 aa)
	A0A1L8H5U5	Uncharacterized protein. (1181 aa)
	Rap1a	Uncharacterized protein. (185 aa)
	A0A1L8H9Y9	Anion exchange protein. (1094 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EL18	cask	A0A1L8EL18	A0A1L8HF63	C2 domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.697
A0A1L8EL18	cask-2	A0A1L8EL18	Q6DCN2	C2 domain-containing protein.	Cask-prov protein; Belongs to the MAGUK family.	0.697
A0A1L8ES30	cask	A0A1L8ES30	A0A1L8HF63	C2 domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.697
A0A1L8ES30	cask-2	A0A1L8ES30	Q6DCN2	C2 domain-containing protein.	Cask-prov protein; Belongs to the MAGUK family.	0.697
A0A1L8GT65	chrm2	A0A1L8GT65	A0A1L8GQL0	Uncharacterized protein.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.542
A0A1L8GYI4	braf	A0A1L8GYI4	A0A1L8GQP3	Uncharacterized protein.	Uncharacterized protein.	0.817
A0A1L8H4T5	Git1	A0A1L8H4T5	A0A1L8HD66	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8HNU7	cask	A0A1L8HNU7	A0A1L8HF63	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.847
A0A1L8HNU7	cask-2	A0A1L8HNU7	Q6DCN2	Uncharacterized protein.	Cask-prov protein; Belongs to the MAGUK family.	0.847
A0A1L8HYF0	cask	A0A1L8HYF0	A0A1L8HF63	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.847
A0A1L8HYF0	cask-2	A0A1L8HYF0	Q6DCN2	Uncharacterized protein.	Cask-prov protein; Belongs to the MAGUK family.	0.847
Chrna5.L	chrm2	A0A1L8H061	A0A1L8GQL0	Uncharacterized protein.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.584
Drd2.L	Drd2.S	A0A1L8FLX5	A0A1L8FG13	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Drd2.S	Drd2.L	A0A1L8FG13	A0A1L8FLX5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Dtnbp1.L	snapin	A0A1L8FY33	Q5PPY9	Uncharacterized protein.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.640
Git1	A0A1L8H4T5	A0A1L8HD66	A0A1L8H4T5	Uncharacterized protein.	Uncharacterized protein.	0.900
P2rx7.L	p2rx1	A0A1L8I177	A0A1L8HGB2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.708
Rap1a	braf	A0A1L8H6I7	A0A1L8GQP3	Uncharacterized protein.	Uncharacterized protein.	0.980
Rap1a	rap1a	A0A1L8H6I7	Q6J1M0	Uncharacterized protein.	MGC80662 protein.	0.901
Rap1a	rap1b	A0A1L8H6I7	A0A1L8GUG3	Uncharacterized protein.	Uncharacterized protein.	0.901