STRINGSTRING
trip12 trip12 A0A1L8EJY7 A0A1L8EJY7 A0A1L8EKP5 A0A1L8EKP5 A0A1L8ELB6 A0A1L8ELB6 A0A1L8ELE2 A0A1L8ELE2 A0A1L8ELW4 A0A1L8ELW4 mfsd11 mfsd11 Ddx5.S Ddx5.S A0A1L8ENC4 A0A1L8ENC4 A0A1L8ENF8 A0A1L8ENF8 Epc2.S Epc2.S March7.S March7.S rif1 rif1 A0A1L8EP79 A0A1L8EP79 ackr3 ackr3 ino80d ino80d smg1 smg1 trrap trrap cops3 cops3 terf2ip terf2ip A0A1L8ESL5 A0A1L8ESL5 A0A1L8ESV1 A0A1L8ESV1 A0A1L8ET07 A0A1L8ET07 mbtd1 mbtd1 Sirt7.L Sirt7.L Brca1.L Brca1.L recql5 recql5 A0A1L8EUJ5 A0A1L8EUJ5 atad5 atad5 Parp9.L Parp9.L A0A1L8EV76 A0A1L8EV76 epc2 epc2 Pla2r1.L Pla2r1.L A0A1L8EW11 A0A1L8EW11 A0A1L8EW93 A0A1L8EW93 Pttg1ip.1.L Pttg1ip.1.L Ino80d.L Ino80d.L Ercc4.L Ercc4.L rmi2 rmi2 Smg1.L Smg1.L nsmce1 nsmce1 Trrap.L Trrap.L cops3-2 cops3-2 Spred1.S Spred1.S Otub2.S Otub2.S A0A1L8F0M8 A0A1L8F0M8 Psmd10.S Psmd10.S fmr1 fmr1 radx radx ppp1r10 ppp1r10 ubqln4 ubqln4 vps72 vps72 muc1 muc1 brcc3 brcc3 trim32 trim32 Cxorf57.L Cxorf57.L ppp1r10-2 ppp1r10-2 Spred1.L Spred1.L rad51 rad51 ino80 ino80 A0A1L8FBI0 A0A1L8FBI0 Ubqln4.L Ubqln4.L Vps72.L Vps72.L A0A1L8FEE0 A0A1L8FEE0 ankrd1 ankrd1 sirt1 sirt1 A0A1L8FEZ9 A0A1L8FEZ9 chek1 chek1 A0A1L8FGQ7 A0A1L8FGQ7 bcl2l12 bcl2l12 A0A1L8FH58 A0A1L8FH58 A0A1L8FH67 A0A1L8FH67 A0A1L8FH77 A0A1L8FH77 kmt5c kmt5c A0A1L8FH84 A0A1L8FH84 pnkp pnkp Casp9.S Casp9.S znf365-2 znf365-2 A0A1L8FJ53 A0A1L8FJ53 A0A1L8FJB7 A0A1L8FJB7 mms19 mms19 Ankrd1.L Ankrd1.L Sirt1.L Sirt1.L A0A1L8FKB7 A0A1L8FKB7 A0A1L8FKB8 A0A1L8FKB8 Parg.L Parg.L A0A1L8FKD8 A0A1L8FKD8 A0A1L8FKE0 A0A1L8FKE0 ercc1 ercc1 ercc6 ercc6 A0A1L8FL85 A0A1L8FL85 chek1-2 chek1-2 A0A1L8FMG2 A0A1L8FMG2 A0A1L8FMY4 A0A1L8FMY4 bcl2l12-2 bcl2l12-2 Kmt5c.L Kmt5c.L Xrcc1.L Xrcc1.L A0A1L8FPV0 A0A1L8FPV0 Setd2.S Setd2.S A0A1L8FQI3 A0A1L8FQI3 A0A1L8FQN2 A0A1L8FQN2 A0A1L8FSQ5 A0A1L8FSQ5 A0A1L8FSS9 A0A1L8FSS9 rbbp8 rbbp8 A0A1L8FSU9 A0A1L8FSU9 ube2v2 ube2v2 A0A1L8FT71 A0A1L8FT71 ubr5 ubr5 A0A1L8FTT4 A0A1L8FTT4 Myc.S Myc.S Setd2.L Setd2.L Cry-dash.L Cry-dash.L A0A1L8FV65 A0A1L8FV65 A0A1L8FVC4 A0A1L8FVC4 A0A1L8FW69 A0A1L8FW69 Wrnip1.L Wrnip1.L A0A1L8FXP8 A0A1L8FXP8 Eef1e1.L Eef1e1.L A0A1L8FYF6 A0A1L8FYF6 Thoc1.L Thoc1.L Clul1.L Clul1.L Rbbp8.L Rbbp8.L A0A1L8FYP6 A0A1L8FYP6 Spidr.L Spidr.L A0A1L8FYX8 A0A1L8FYX8 snai2 snai2 Prkdc.L Prkdc.L A0A1L8FZR0 A0A1L8FZR0 actr2 actr2 rnf8 rnf8 Smyd2-b Smyd2-b A0A1L8G1M7 A0A1L8G1M7 fbxo5 fbxo5 bclaf1 bclaf1 fxr1 fxr1 rnf168 rnf168 Smyd2.S Smyd2.S Bre.L Bre.L RNF8 RNF8 actr2-2 actr2-2 A0A1L8G927 A0A1L8G927 A0A1L8GA38 A0A1L8GA38 A0A1L8GA79 A0A1L8GA79 Atr.L Atr.L trip12-2 trip12-2 rnf168-2 rnf168-2 Pbk.L Pbk.L kmt5b kmt5b A0A1L8GDT7 A0A1L8GDT7 spire2 spire2 usp1 usp1 rfwd3 rfwd3 A0A1L8GG25 A0A1L8GG25 A0A1L8GGQ9 A0A1L8GGQ9 uchl5 uchl5 A0A1L8GIG5 A0A1L8GIG5 Otub1.L Otub1.L kmt5b-2 kmt5b-2 Usp1-b Usp1-b rfwd3-2 rfwd3-2 A0A1L8GMQ0 A0A1L8GMQ0 A0A1L8GNC2 A0A1L8GNC2 Uchl5.L Uchl5.L parp3 parp3 setmar setmar ruvbl1 ruvbl1 ogg1 ogg1 Rad52.S Rad52.S A0A1L8GQR5 A0A1L8GQR5 Tigar.S Tigar.S Foxm1.S Foxm1.S Cd74.S Cd74.S nkx3-1 nkx3-1 Wdr76.S Wdr76.S A0A1L8GSA4 A0A1L8GSA4 A0A1L8GSW6 A0A1L8GSW6 arid2 arid2 A0A1L8GUX4 A0A1L8GUX4 A0A1L8GW81 A0A1L8GW81 A0A1L8GWC1 A0A1L8GWC1 Ddx11.L Ddx11.L armt1 armt1 Cry1.L Cry1.L brd8 brd8 A0A1L8GY09 A0A1L8GY09 Parpbp.L Parpbp.L helb helb A0A1L8GYK5 A0A1L8GYK5 arid2-2 arid2-2 Pot1.L Pot1.L Fbxo18.L Fbxo18.L tp53bp1 tp53bp1 Fem1b.L Fem1b.L Nkx3-1.L Nkx3-1.L tti2 tti2 cdkn2d cdkn2d wrap53 wrap53 A0A1L8H473 A0A1L8H473 A0A1L8H4E0 A0A1L8H4E0 Tp53.L Tp53.L A0A1L8H4Q1 A0A1L8H4Q1 Klhl15.S Klhl15.S A0A1L8H7I8 A0A1L8H7I8 A0A1L8H7W7 A0A1L8H7W7 A0A1L8H827 A0A1L8H827 A0A1L8H9R2 A0A1L8H9R2 znf385a znf385a A0A1L8HBA4 A0A1L8HBA4 rnf169 rnf169 A0A1L8HCW5 A0A1L8HCW5 hic1 hic1 klhl15 klhl15 Eya3.L Eya3.L A0A1L8HEF9 A0A1L8HEF9 kdm1a kdm1a zmpste24 zmpste24 A0A1L8HHN1 A0A1L8HHN1 A0A1L8HHZ4 A0A1L8HHZ4 znf385a-2 znf385a-2 A0A1L8HJT1 A0A1L8HJT1 rps3 rps3 rnf169-2 rnf169-2 fam168a fam168a Nsd2.S Nsd2.S Pias4.S Pias4.S A0A1L8HMX2 A0A1L8HMX2 A0A1L8HN08 A0A1L8HN08 A0A1L8HN09 A0A1L8HN09 abraxas1 abraxas1 thoc5 thoc5 triap1 triap1 kmt5a kmt5a bcl7a bcl7a A0A1L8HQY0 A0A1L8HQY0 nsd2 nsd2 A0A1L8HVY7 A0A1L8HVY7 hdgfl2 hdgfl2 Pias4.L Pias4.L A0A1L8HWA2 A0A1L8HWA2 A0A1L8HWD5 A0A1L8HWD5 A0A1L8HWS5 A0A1L8HWS5 Tmem161a.L Tmem161a.L babam1 babam1 A0A1L8HXU1 A0A1L8HXU1 thoc5-2 thoc5-2 A0A1L8I081 A0A1L8I081 A0A1L8I088 A0A1L8I088 Chek2.L Chek2.L kmt5a-2 kmt5a-2 bcl7a-2 bcl7a-2 A0A1L8I1D4 A0A1L8I1D4 A0A1L8I1K3 A0A1L8I1K3 slf1 slf1 A0A1L8I2B2 A0A1L8I2B2 A0A310TNS6 A0A310TNS6 Spire2.L Spire2.L Xrcc1.S Xrcc1.S A0A310TYZ2 A0A310TYZ2 A0A310U513 A0A310U513 A0A310U749 A0A310U749 A0A310U7M2 A0A310U7M2 LOC100037190 LOC100037190 fxr1-2 fxr1-2 LOC100049093 LOC100049093 fbxo4 fbxo4 fmr1-A fmr1-A hmga2 hmga2 ruvbl2 ruvbl2 dek dek parp1 parp1 otub1 otub1 cebpg cebpg ercc8 ercc8 psmd10 psmd10 DDX5 DDX5 dmap1 dmap1 hmga2-2 hmga2-2 fam168a-2 fam168a-2 cdkn2d-2 cdkn2d-2 cry4 cry4 spire1 spire1 sirt6 sirt6 ruvbl1-2 ruvbl1-2 myc myc yeats4 yeats4 cd74 cd74 mcrs1 mcrs1 clu clu actl6a actl6a rpls3-b rpls3-b ackr3-2 ackr3-2 snai2-2 snai2-2 pcna pcna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trip12Uncharacterized protein. (2054 aa)
A0A1L8EJY7Uncharacterized protein. (68 aa)
A0A1L8EKP5Rap1_C domain-containing protein. (136 aa)
A0A1L8ELB6Uncharacterized protein. (261 aa)
A0A1L8ELE2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (554 aa)
A0A1L8ELW4Uncharacterized protein. (158 aa)
mfsd11Uncharacterized protein. (445 aa)
Ddx5.SUncharacterized protein; Belongs to the DEAD box helicase family. (655 aa)
A0A1L8ENC4AAA domain-containing protein. (1731 aa)
A0A1L8ENF8Uncharacterized protein. (835 aa)
Epc2.SEnhancer of polycomb homolog. (804 aa)
March7.SRING-CH-type domain-containing protein. (732 aa)
rif1Rif1_N domain-containing protein. (2326 aa)
A0A1L8EP79Uncharacterized protein. (788 aa)
ackr3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ino80dUncharacterized protein. (1025 aa)
smg1Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3654 aa)
trrapUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3838 aa)
cops3PCI domain-containing protein. (423 aa)
terf2ipUncharacterized protein. (513 aa)
A0A1L8ESL5Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (523 aa)
A0A1L8ESV1KIND domain-containing protein. (453 aa)
A0A1L8ET07Uncharacterized protein. (200 aa)
mbtd1FCS-type domain-containing protein. (621 aa)
Sirt7.LDeacetylase sirtuin-type domain-containing protein. (393 aa)
Brca1.LUncharacterized protein. (1582 aa)
recql5Uncharacterized protein. (1090 aa)
A0A1L8EUJ5Uncharacterized protein. (445 aa)
atad5AAA domain-containing protein. (1740 aa)
Parp9.LPoly [ADP-ribose] polymerase. (920 aa)
A0A1L8EV76RING-type domain-containing protein. (695 aa)
epc2Enhancer of polycomb homolog. (804 aa)
Pla2r1.LUncharacterized protein. (1534 aa)
A0A1L8EW11RING-CH-type domain-containing protein. (735 aa)
A0A1L8EW93Uncharacterized protein. (793 aa)
Pttg1ip.1.LUncharacterized protein. (172 aa)
Ino80d.LUncharacterized protein. (1025 aa)
Ercc4.LERCC4 domain-containing protein. (924 aa)
rmi2Uncharacterized protein. (152 aa)
Smg1.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3654 aa)
nsmce1zf-RING-like domain-containing protein. (270 aa)
Trrap.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3828 aa)
cops3-2PCI domain-containing protein. (423 aa)
Spred1.SWH1 domain-containing protein. (223 aa)
Otub2.SUbiquitin thioesterase. (279 aa)
A0A1L8F0M8Uncharacterized protein. (195 aa)
Psmd10.SANK_REP_REGION domain-containing protein. (270 aa)
fmr1Uncharacterized protein. (564 aa)
radxUncharacterized protein. (834 aa)
ppp1r10Uncharacterized protein. (819 aa)
ubqln4Uncharacterized protein. (600 aa)
vps72YL1_C domain-containing protein. (364 aa)
muc1SEA domain-containing protein. (692 aa)
brcc3MPN domain-containing protein. (261 aa)
trim32Uncharacterized protein. (649 aa)
Cxorf57.LUncharacterized protein. (839 aa)
ppp1r10-2Uncharacterized protein. (843 aa)
Spred1.LUncharacterized protein. (405 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
ino80Uncharacterized protein. (1539 aa)
A0A1L8FBI0RING-type domain-containing protein. (218 aa)
Ubqln4.LUncharacterized protein. (599 aa)
Vps72.LYL1_C domain-containing protein. (355 aa)
A0A1L8FEE0DNA_binding_1 domain-containing protein. (101 aa)
ankrd1ANK_REP_REGION domain-containing protein. (317 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
A0A1L8FEZ9MMS19_N domain-containing protein. (153 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
A0A1L8FGQ7Uncharacterized protein. (250 aa)
bcl2l12Uncharacterized protein. (459 aa)
A0A1L8FH58RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (47 aa)
A0A1L8FH67RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (122 aa)
A0A1L8FH77RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (108 aa)
kmt5cSET domain-containing protein. (827 aa)
A0A1L8FH84RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (54 aa)
pnkpFHA_2 domain-containing protein. (594 aa)
Casp9.SUncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
znf365-2Uncharacterized protein. (396 aa)
A0A1L8FJ53Uncharacterized protein. (186 aa)
A0A1L8FJB7Uncharacterized protein. (1021 aa)
mms19Uncharacterized protein. (1022 aa)
Ankrd1.LANK_REP_REGION domain-containing protein. (318 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
A0A1L8FKB7Uncharacterized protein. (31 aa)
A0A1L8FKB8Uncharacterized protein. (75 aa)
Parg.LUncharacterized protein. (79 aa)
A0A1L8FKD8Uncharacterized protein. (46 aa)
A0A1L8FKE0Uncharacterized protein. (35 aa)
ercc1Uncharacterized protein. (297 aa)
ercc6Uncharacterized protein. (1370 aa)
A0A1L8FL85NFRKB_winged domain-containing protein. (1263 aa)
chek1-2Protein kinase domain-containing protein. (510 aa)
A0A1L8FMG2Uncharacterized protein. (446 aa)
A0A1L8FMY4Uncharacterized protein. (267 aa)
bcl2l12-2Uncharacterized protein. (459 aa)
Kmt5c.LSET domain-containing protein. (761 aa)
Xrcc1.LUncharacterized protein. (651 aa)
A0A1L8FPV0Uncharacterized protein. (145 aa)
Setd2.SUncharacterized protein. (2779 aa)
A0A1L8FQI3WD_REPEATS_REGION domain-containing protein. (644 aa)
A0A1L8FQN2Enhancer of polycomb homolog. (810 aa)
A0A1L8FSQ5KIND domain-containing protein. (798 aa)
A0A1L8FSS9Uncharacterized protein. (76 aa)
rbbp8Uncharacterized protein. (846 aa)
A0A1L8FSU9Uncharacterized protein. (402 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
A0A1L8FT71Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ubr5Uncharacterized protein. (2799 aa)
A0A1L8FTT4BHLH domain-containing protein. (191 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
Setd2.LUncharacterized protein. (2860 aa)
Cry-dash.LPhotolyase/cryptochrome alpha/beta domain-containing protein. (523 aa)
A0A1L8FV65WD_REPEATS_REGION domain-containing protein. (991 aa)
A0A1L8FVC4Enhancer of polycomb homolog. (760 aa)
A0A1L8FW69Uncharacterized protein. (279 aa)
Wrnip1.LUncharacterized protein. (572 aa)
A0A1L8FXP8Uncharacterized protein. (349 aa)
Eef1e1.LGST C-terminal domain-containing protein. (174 aa)
A0A1L8FYF6KIND domain-containing protein. (729 aa)
Thoc1.LDeath domain-containing protein. (669 aa)
Clul1.LClusterin; Belongs to the clusterin family. (392 aa)
Rbbp8.LUncharacterized protein. (856 aa)
A0A1L8FYP6SMC hinge domain-containing protein. (1987 aa)
Spidr.LUncharacterized protein. (866 aa)
A0A1L8FYX8UBIQUITIN_CONJUGAT_2 domain-containing protein. (137 aa)
snai2Uncharacterized protein. (266 aa)
Prkdc.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
A0A1L8FZR0Uncharacterized protein. (2520 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
Smyd2-bUncharacterized protein. (430 aa)
A0A1L8G1M7Uncharacterized protein. (134 aa)
fbxo5F-box domain-containing protein. (392 aa)
bclaf1Btz domain-containing protein. (852 aa)
fxr1Uncharacterized protein. (675 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa)
Smyd2.SSET domain-containing protein. (369 aa)
Bre.LUncharacterized protein. (404 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
actr2-2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
A0A1L8G927Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (638 aa)
A0A1L8GA38c-SKI_SMAD_bind domain-containing protein. (643 aa)
A0A1L8GA79Uncharacterized protein; Belongs to the actin family. (421 aa)
Atr.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
trip12-2Uncharacterized protein. (2028 aa)
rnf168-2E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa)
Pbk.LProtein kinase domain-containing protein. (325 aa)
kmt5bSET domain-containing protein. (855 aa)
A0A1L8GDT7USP domain-containing protein; Belongs to the peptidase C19 family. (1373 aa)
spire2Uncharacterized protein. (712 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (766 aa)
rfwd3RING-type domain-containing protein. (750 aa)
A0A1L8GG25Uncharacterized protein. (1252 aa)
A0A1L8GGQ9BZIP domain-containing protein. (137 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
A0A1L8GIG5USP domain-containing protein; Belongs to the peptidase C19 family. (1690 aa)
Otub1.LUbiquitin thioesterase. (268 aa)
kmt5b-2SET domain-containing protein. (877 aa)
Usp1-bUbiquitin carboxyl-terminal hydrolase. (780 aa)
rfwd3-2RING-type domain-containing protein. (751 aa)
A0A1L8GMQ0Uncharacterized protein. (1244 aa)
A0A1L8GNC2FAM35_C domain-containing protein. (787 aa)
Uchl5.LUbiquitin carboxyl-terminal hydrolase. (329 aa)
parp3Poly [ADP-ribose] polymerase. (547 aa)
setmarUncharacterized protein. (275 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
ogg1ENDO3c domain-containing protein. (432 aa)
Rad52.SUncharacterized protein. (429 aa)
A0A1L8GQR5Photolyase/cryptochrome alpha/beta domain-containing protein. (585 aa)
Tigar.SUncharacterized protein. (275 aa)
Foxm1.SFork-head domain-containing protein. (762 aa)
Cd74.SThyroglobulin type-1 domain-containing protein. (302 aa)
nkx3-1Homeobox domain-containing protein. (213 aa)
Wdr76.SWD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (584 aa)
A0A1L8GSA4Uncharacterized protein. (629 aa)
A0A1L8GSW6Uncharacterized protein. (2175 aa)
arid2Uncharacterized protein. (1809 aa)
A0A1L8GUX4Bromo domain-containing protein. (807 aa)
A0A1L8GW81Uncharacterized protein. (167 aa)
A0A1L8GWC1Uncharacterized protein. (441 aa)
Ddx11.LHelicase ATP-binding domain-containing protein. (898 aa)
armt1DUF89 domain-containing protein. (440 aa)
Cry1.LPhotolyase/cryptochrome alpha/beta domain-containing protein. (616 aa)
brd8Bromo domain-containing protein. (934 aa)
A0A1L8GY09RAP80_UIM domain-containing protein. (937 aa)
Parpbp.LUncharacterized protein. (451 aa)
helbUvrD_C_2 domain-containing protein. (1071 aa)
A0A1L8GYK5Uncharacterized protein. (325 aa)
arid2-2Uncharacterized protein. (1812 aa)
Pot1.LTelo_bind domain-containing protein. (621 aa)
Fbxo18.LF-box domain-containing protein. (1038 aa)
tp53bp1Uncharacterized protein. (2179 aa)
Fem1b.LUncharacterized protein. (673 aa)
Nkx3-1.LHomeobox domain-containing protein. (213 aa)
tti2Uncharacterized protein. (341 aa)
cdkn2dANK_REP_REGION domain-containing protein. (161 aa)
wrap53WD_REPEATS_REGION domain-containing protein. (654 aa)
A0A1L8H473HIT-type domain-containing protein. (160 aa)
A0A1L8H4E0Uncharacterized protein. (312 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H4Q1Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
Klhl15.SBTB domain-containing protein. (241 aa)
A0A1L8H7I8Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
A0A1L8H7W7Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (739 aa)
A0A1L8H827CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa)
A0A1L8H9R2Uncharacterized protein. (1288 aa)
znf385aUncharacterized protein. (403 aa)
A0A1L8HBA4Uncharacterized protein. (103 aa)
rnf169Uncharacterized protein. (483 aa)
A0A1L8HCW5Uncharacterized protein. (858 aa)
hic1Uncharacterized protein. (659 aa)
klhl15BTB domain-containing protein. (604 aa)
Eya3.LEyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (566 aa)
A0A1L8HEF9Uncharacterized protein. (318 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
A0A1L8HHN1TCTP domain-containing protein; Belongs to the TCTP family. (172 aa)
A0A1L8HHZ4Uncharacterized protein. (1214 aa)
znf385a-2Uncharacterized protein. (406 aa)
A0A1L8HJT1Rep_fac-A_C domain-containing protein. (793 aa)
rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
rnf169-2Uncharacterized protein. (496 aa)
fam168aUncharacterized protein. (358 aa)
Nsd2.SUncharacterized protein. (1300 aa)
Pias4.SUncharacterized protein. (543 aa)
A0A1L8HMX2PWWP domain-containing protein. (639 aa)
A0A1L8HN08DUF3715 domain-containing protein. (249 aa)
A0A1L8HN09Uncharacterized protein. (1894 aa)
abraxas1MPN domain-containing protein. (408 aa)
thoc5Uncharacterized protein. (678 aa)
triap1Uncharacterized protein. (78 aa)
kmt5aSET domain-containing protein. (335 aa)
bcl7aUncharacterized protein. (229 aa)
A0A1L8HQY0Uncharacterized protein. (336 aa)
nsd2Uncharacterized protein. (1300 aa)
A0A1L8HVY7Uncharacterized protein. (326 aa)
hdgfl2PWWP domain-containing protein. (642 aa)
Pias4.LUncharacterized protein. (544 aa)
A0A1L8HWA2Uncharacterized protein. (1996 aa)
A0A1L8HWD5DUF3715 domain-containing protein. (380 aa)
A0A1L8HWS5Uncharacterized protein. (1325 aa)
Tmem161a.LUncharacterized protein. (489 aa)
babam1Uncharacterized protein. (328 aa)
A0A1L8HXU1GST C-terminal domain-containing protein. (195 aa)
thoc5-2Uncharacterized protein. (678 aa)
A0A1L8I081Uncharacterized protein. (96 aa)
A0A1L8I088Uncharacterized protein. (78 aa)
Chek2.LUncharacterized protein. (392 aa)
kmt5a-2SET domain-containing protein. (336 aa)
bcl7a-2Uncharacterized protein. (231 aa)
A0A1L8I1D4Uncharacterized protein. (159 aa)
A0A1L8I1K3Uncharacterized protein. (275 aa)
slf1ANK_REP_REGION domain-containing protein. (904 aa)
A0A1L8I2B2Uncharacterized protein. (248 aa)
A0A310TNS6c-SKI_SMAD_bind domain-containing protein. (628 aa)
Spire2.LUncharacterized protein. (712 aa)
Xrcc1.SUncharacterized protein. (591 aa)
A0A310TYZ2SET domain-containing protein. (107 aa)
A0A310U513MMS19_C domain-containing protein. (636 aa)
A0A310U749Uncharacterized protein. (259 aa)
A0A310U7M2Uncharacterized protein. (384 aa)
LOC100037190LOC100037190 protein. (331 aa)
fxr1-2LOC398050 protein. (649 aa)
LOC100049093LOC100049093 protein. (452 aa)
fbxo4LOC100158284 protein. (384 aa)
fmr1-AFragile X mental retardation 1. (564 aa)
hmga2LOC100158391 protein. (105 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (462 aa)
dekDEK_C domain-containing protein. (391 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
otub1Ubiquitin thioesterase. (269 aa)
cebpgMGC114733 protein. (143 aa)
ercc8LOC496353 protein. (399 aa)
psmd10LOC495968 protein. (227 aa)
DDX5DDX5 protein; Belongs to the DEAD box helicase family. (608 aa)
dmap1MGC82015 protein. (464 aa)
hmga2-2MGC81571 protein. (105 aa)
fam168a-2MGC86305 protein. (235 aa)
cdkn2d-2Ank2-prov protein. (161 aa)
cry4Cry1 protein. (556 aa)
spire1Spire2 protein. (642 aa)
sirt6MGC82564 protein. (331 aa)
ruvbl1-2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
yeats4MGC68689 protein. (227 aa)
cd74MGC68635 protein. (293 aa)
mcrs1Mcrs1-prov protein. (453 aa)
cluClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
actl6aBaf53a-pending-prov protein; Belongs to the actin family. (429 aa)
rpls3-bRpls3-b protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
ackr3-2RDC1 like protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
snai2-2Zinc finger transcription factor slug beta. (266 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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