Your Input: | |
| | slf1 | ANK_REP_REGION domain-containing protein. (904 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (547 aa) |
| | setmar | Uncharacterized protein. (275 aa) |
| | A0A1L8GSW6 | Uncharacterized protein. (2175 aa) |
| | A0A1L8GW81 | Uncharacterized protein. (167 aa) |
| | tp53bp1 | Uncharacterized protein. (2179 aa) |
| | A0A1L8HBA4 | Uncharacterized protein. (103 aa) |
| | rnf169 | Uncharacterized protein. (483 aa) |
| | arpc2-b | Actin-related protein 2/3 complex subunit 2-B; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous r [...] (300 aa) |
| | arpc5-b | Actin-related protein 2/3 complex subunit 5-B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous [...] (152 aa) |
| | arpc5-a | Actin-related protein 2/3 complex subunit 5-A; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair [...] (150 aa) |
| | arpc4 | Actin-related protein 2/3 complex subunit 4; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) [...] (168 aa) |
| | arpc5-c | Actin-related protein 2/3 complex subunit 5-C; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombinat [...] (150 aa) |
| | narf | Narf protein. (222 aa) |
| | arpc2-a | Actin-related protein 2/3 complex subunit 2-A; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombinatio [...] (300 aa) |
| | arpc3-a | Actin-related protein 2/3 complex subunit 3-A; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in re [...] (178 aa) |
| | wdr70 | WD_REPEATS_REGION domain-containing protein. (627 aa) |
| | A0A1L8I2B2 | Uncharacterized protein. (248 aa) |
| | A0A1L8GNC2 | FAM35_C domain-containing protein. (787 aa) |
| | A0A1L8HV81 | Helicase C-terminal domain-containing protein. (260 aa) |
| | A0A1L8HV78 | Helicase ATP-binding domain-containing protein. (241 aa) |
| | A0A1L8HV66 | CUE domain-containing protein. (479 aa) |
| | smarcad1 | Uncharacterized protein. (1001 aa) |
| | rnf169-2 | Uncharacterized protein. (496 aa) |
| | A0A1L8EU46 | HD domain-containing protein. (476 aa) |
| | samhd1 | Uncharacterized protein. (632 aa) |
| | A0A1L8EU76 | HD domain-containing protein. (270 aa) |
| | actr3-b | Actin-related protein 3-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damag [...] (418 aa) |
| | arpc1a-b | Actin-related protein 2/3 complex subunit 1A-B; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). (370 aa) |
| | A0A1L8F537 | Uncharacterized protein. (965 aa) |
| | ints3 | Uncharacterized protein. (1018 aa) |
| | iffo1 | IF rod domain-containing protein; Belongs to the intermediate filament family. (487 aa) |
| | pnkp | FHA_2 domain-containing protein. (594 aa) |
| | A0A1L8FHJ6 | IF rod domain-containing protein; Belongs to the intermediate filament family. (427 aa) |
| | iffo1-2 | IF rod domain-containing protein; Belongs to the intermediate filament family. (487 aa) |
| | arpc1a-a | Actin-related protein 2/3 complex subunit 1A-A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). (370 aa) |
| | actr3-a | Actin-related protein 3-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable [...] (418 aa) |
| | arpc3-b | Actin-related protein 2/3 complex subunit 3-B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair [...] (178 aa) |
| | A0A1L8FJB7 | Uncharacterized protein. (1021 aa) |
| | poll | BRCT domain-containing protein; Belongs to the DNA polymerase type-X family. (577 aa) |
| | A0A1L8FPD4 | IF rod domain-containing protein; Belongs to the intermediate filament family. (472 aa) |
| | A0A1L8FU98 | ANK_REP_REGION domain-containing protein. (651 aa) |
| | rnf138 | zf-Di19 domain-containing protein. (126 aa) |
| | A0A1L8G061 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1305 aa) |
| | A0A1L8G0I6 | Uncharacterized protein. (1423 aa) |
| | A0A1L8G1M7 | Uncharacterized protein. (134 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa) |
| | aplf | Uncharacterized protein. (510 aa) |
| | ufl1 | Uncharacterized protein. (795 aa) |
| | rnf168-2 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa) |
