(100 nodes) Thioredoxin-like superfamily network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gdap1l1	Uncharacterized protein. (364 aa)
	ubxn4	UBX domain-containing protein. (514 aa)
	Dnajc10.S	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (796 aa)
	pdia2	Protein disulfide-isomerase. (526 aa)
	gdap1l1-2	Uncharacterized protein. (364 aa)
	A0A1L8EUG3	Thioredox_DsbH domain-containing protein. (780 aa)
	sco1	Uncharacterized protein. (278 aa)
	ubxn4-2	UBX domain-containing protein. (514 aa)
	dnajc10	Uncharacterized protein. (797 aa)
	txndc11	Uncharacterized protein. (891 aa)
	glrx5	Glutaredoxin domain-containing protein. (171 aa)
	tmx1	Thioredoxin domain-containing protein. (264 aa)
	clic3	GST N-terminal domain-containing protein. (240 aa)
	pdcl	Phosducin domain-containing protein. (292 aa)
	sh3bgrl	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (117 aa)
	clic1	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (240 aa)
	txndc16	Thioredoxin domain-containing protein. (809 aa)
	A0A1L8FCN2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (429 aa)
	A0A1L8FCS1	Uncharacterized protein. (211 aa)
	dnajc16	Uncharacterized protein. (777 aa)
	nhlrc2	Thioredoxin domain-containing protein. (794 aa)
	gstk1	Glutathione S-transferase kappa. (223 aa)
	glrx3	Uncharacterized protein. (326 aa)
	A0A1L8FJ84	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	A0A1L8FJ87	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	dnajc16-2	Uncharacterized protein. (777 aa)
	txndc5	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (404 aa)
	A0A1L8FT90	Glutaredoxin-like protein; Belongs to the glutaredoxin family. (111 aa)
	agr3	Uncharacterized protein. (165 aa)
	ndufv2-2	Uncharacterized protein. (243 aa)
	gdap1	Uncharacterized protein; Belongs to the GST superfamily. (347 aa)
	A0A1L8G2Z4	Uncharacterized protein. (404 aa)
	gsta1	Uncharacterized protein; Belongs to the GST superfamily. (220 aa)
	Clic6.L	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (378 aa)
	A0A1L8G9D5	Uncharacterized protein. (406 aa)
	ubxn7	UBX domain-containing protein 7. (508 aa)
	A0A1L8GCQ9	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (189 aa)
	txn2	Thioredoxin domain-containing protein. (223 aa)
	Erp27.S	Uncharacterized protein. (271 aa)
	mrps25	L51_S25_CI-B8 domain-containing protein. (173 aa)
	glrx2	Glutaredoxin domain-containing protein. (160 aa)
	Pdc.L	Phosducin domain-containing protein. (246 aa)
	erp27	Uncharacterized protein. (267 aa)
	A0A1L8GWZ4	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (100 aa)
	pdia3	Protein disulfide-isomerase. (500 aa)
	nxnl1	Thioredoxin-like_fold domain-containing protein. (215 aa)
	A0A1L8H5B5	GST N-terminal domain-containing protein. (816 aa)
	pdcl3	Phosducin domain-containing protein. (237 aa)
	nxn-2	Thioredoxin domain-containing protein. (414 aa)
	txndc9	Thioredoxin domain-containing protein. (226 aa)
	grxcr1	Glutaredoxin domain-containing protein. (301 aa)
	hpgds	Uncharacterized protein; Belongs to the GST superfamily. (194 aa)
	A0A1L8HPD3	Thioredoxin-like_fold domain-containing protein. (156 aa)
	erp29	Uncharacterized protein. (261 aa)
	A0A1L8HR55	Glutaredoxin domain-containing protein. (107 aa)
	grxcr1-2	Glutaredoxin domain-containing protein. (290 aa)
	tusc3	Uncharacterized protein. (346 aa)
	hpgds-2	Uncharacterized protein. (193 aa)
	A0A1L8HY24	Thioredoxin domain-containing protein. (108 aa)
	A0A1L8I0D9	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	gstt1-like.2	Uncharacterized protein. (244 aa)
	A0A1L8I224	Sep15_SelM domain-containing protein. (138 aa)
	LOC100037235	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	mrps25-2	LOC100049746 protein. (173 aa)
	gsto2	LOC100037104 protein; Belongs to the GST superfamily. (241 aa)
	txndc12	Thioredoxin domain-containing protein. (168 aa)
	tmx1-2	LOC100158326 protein. (264 aa)
	PRDX2	Peroxiredoxin 2. (202 aa)
	gstz1	LOC496168 protein; Belongs to the GST superfamily. (216 aa)
	txndc17	MGC131361 protein. (124 aa)
	gsta4	MGC115418 protein. (229 aa)
	gpx1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (143 aa)
	sh3bgrl-2	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (117 aa)
	txnl4b	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
	txnl4a	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
	gpx1-2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (143 aa)
	txn	LOC495354 protein. (105 aa)
	gpx7-2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
	txnrd3-2	MGC81848 protein. (596 aa)
	p4hb	Protein disulfide-isomerase. (506 aa)
	txnl1	MGC81675 protein. (289 aa)
	pdcl3-2	MGC78962 protein. (237 aa)
	clic4	MGC83873 protein. (252 aa)
	clic1-2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (240 aa)
	sh3bgr-2	MGC82574 protein. (189 aa)
	MGC80314	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	clic4-2	CLIC4 protein. (252 aa)
	nxnl2	MGC83491 protein. (156 aa)
	MGC83501	MGC83501 protein. (199 aa)
	gstt1	MGC81156 protein; Belongs to the GST superfamily. (242 aa)
	faf1	MGC80303 protein. (655 aa)
	sh3bgrl3	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (93 aa)
	prdx6	MGC64582 protein. (224 aa)
	prdx6-2	Prdx6-prov protein. (224 aa)
	gstm1	Gstm2-prov protein. (219 aa)
	pdia6	Pdip5-prov protein; Belongs to the protein disulfide isomerase family. (442 aa)
	pdia3-2	Protein disulfide-isomerase. (502 aa)
	txndc12-2	Tlp19-prov protein. (168 aa)
	txn2-2	Txn2-prov protein. (170 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EUG3	ndufv2-2	A0A1L8EUG3	A0A1L8FYH9	Thioredox_DsbH domain-containing protein.	Uncharacterized protein.	0.416
A0A1L8EUG3	txnl4a	A0A1L8EUG3	Q5HZ93	Thioredox_DsbH domain-containing protein.	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.	0.568
A0A1L8EUG3	txnl4b	A0A1L8EUG3	Q5BIY3	Thioredox_DsbH domain-containing protein.	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.	0.552
A0A1L8FCS1	A0A1L8FJ84	A0A1L8FCS1	A0A1L8FJ84	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.594
A0A1L8FCS1	A0A1L8FJ87	A0A1L8FCS1	A0A1L8FJ87	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.594
A0A1L8FCS1	A0A1L8I0D9	A0A1L8FCS1	A0A1L8I0D9	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.522
A0A1L8FCS1	MGC83501	A0A1L8FCS1	Q6IND2	Uncharacterized protein.	MGC83501 protein.	0.405
A0A1L8FCS1	PRDX2	A0A1L8FCS1	G3GBS3	Uncharacterized protein.	Peroxiredoxin 2.	0.405
A0A1L8FCS1	gsta1	A0A1L8FCS1	A0A1L8G3N9	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.454
A0A1L8FCS1	gsta4	A0A1L8FCS1	Q4V7T2	Uncharacterized protein.	MGC115418 protein.	0.454
A0A1L8FCS1	gstm1	A0A1L8FCS1	Q7SZ23	Uncharacterized protein.	Gstm2-prov protein.	0.677
A0A1L8FCS1	gsto2	A0A1L8FCS1	A8E5X8	Uncharacterized protein.	LOC100037104 protein; Belongs to the GST superfamily.	0.594
A0A1L8FCS1	gstt1	A0A1L8FCS1	Q6INS0	Uncharacterized protein.	MGC81156 protein; Belongs to the GST superfamily.	0.522
A0A1L8FCS1	gstt1-like.2	A0A1L8FCS1	A0A1L8I0H1	Uncharacterized protein.	Uncharacterized protein.	0.522
A0A1L8FCS1	gstz1	A0A1L8FCS1	Q3B8M0	Uncharacterized protein.	LOC496168 protein; Belongs to the GST superfamily.	0.852
A0A1L8FCS1	hpgds	A0A1L8FCS1	A0A1L8HMC5	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.576
A0A1L8FCS1	hpgds-2	A0A1L8FCS1	A0A1L8HV33	Uncharacterized protein.	Uncharacterized protein.	0.569
A0A1L8FCS1	prdx6	A0A1L8FCS1	Q7SYQ4	Uncharacterized protein.	MGC64582 protein.	0.797
A0A1L8FCS1	prdx6-2	A0A1L8FCS1	Q7SYT1	Uncharacterized protein.	Prdx6-prov protein.	0.797
A0A1L8FJ84	A0A1L8FCS1	A0A1L8FJ84	A0A1L8FCS1	Uncharacterized protein; Belongs to the GST superfamily.	Uncharacterized protein.	0.594