50 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8ENC4	AAA domain-containing protein. (1731 aa)
	ddb1	CPSF_A domain-containing protein. (1140 aa)
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	rps27a	MGC81889 protein. (156 aa)
	rpa3-2	Rpa3-prov protein. (121 aa)
	rpa3	LOC495401 protein. (121 aa)
	rfc3	MGC115007 protein. (356 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2285 aa)
	A0A1L8HX68	Ubiquitin-like domain-containing protein. (173 aa)
	Kxd1.L	KxDL domain-containing protein. (195 aa)
	rfc1	Replication factor C subunit 1. (1147 aa)
	Rfc5.S	AAA domain-containing protein. (335 aa)
	ubc	Uncharacterized protein. (533 aa)
	kxd1	KxDL domain-containing protein. (195 aa)
	A0A1L8HK04	Uncharacterized protein. (779 aa)
	Rcbtb1.L	BTB domain-containing protein. (600 aa)
	A0A1L8HH08	CULLIN_2 domain-containing protein; Belongs to the cullin family. (753 aa)
	Rfc2.L	AAA domain-containing protein. (359 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	A0A1L8HCZ9	Uncharacterized protein. (307 aa)
	Rcbtb1.S	BTB domain-containing protein. (600 aa)
	cul4a	CULLIN_2 domain-containing protein; Belongs to the cullin family. (753 aa)
	A0A1L8H4R2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
	pold2	Uncharacterized protein. (463 aa)
	Pole4.L	CBFD_NFYB_HMF domain-containing protein. (206 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	A0A1L8GPG9	Uncharacterized protein. (447 aa)
	Rbx1.L	RING-type domain-containing protein. (168 aa)
	Usp1-b	Ubiquitin carboxyl-terminal hydrolase. (780 aa)
	rbx1	RING-type domain-containing protein. (120 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	A0A1L8G5V1	Ubiquitin-like domain-containing protein. (156 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)
	A0A1L8FV65	WD_REPEATS_REGION domain-containing protein. (991 aa)
	A0A1L8FTA7	Ubiquitin-like domain-containing protein. (105 aa)
	A0A1L8FQI3	WD_REPEATS_REGION domain-containing protein. (644 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	Pole2.L	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (569 aa)
	A0A1L8F746	CULLIN_2 domain-containing protein; Belongs to the cullin family. (848 aa)
	Cul4b.S	CULLIN_2 domain-containing protein; Belongs to the cullin family. (866 aa)
	A0A1L8F0R3	Uncharacterized protein. (136 aa)
	Meiob.L	Uncharacterized protein. (470 aa)
	atad5	AAA domain-containing protein. (1740 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	rcbtb2	Chc1l-prov protein. (526 aa)
	rfc5	Rfc5-prov protein. (335 aa)
	ubc-2	Ubc-prov protein. (609 aa)
	rfc4	Replication factor C p37 subunit. (363 aa)
	pole3	DNA polymerase epsilon p17 subunit. (147 aa)
	uba52	MGC80109 protein. (128 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENC4	A0A1L8F0R3	A0A1L8ENC4	A0A1L8F0R3	AAA domain-containing protein.	Uncharacterized protein.	0.757
A0A1L8ENC4	A0A1L8FQI3	A0A1L8ENC4	A0A1L8FQI3	AAA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.826
A0A1L8ENC4	A0A1L8FV65	A0A1L8ENC4	A0A1L8FV65	AAA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.826
A0A1L8ENC4	A0A1L8G5V1	A0A1L8ENC4	A0A1L8G5V1	AAA domain-containing protein.	Ubiquitin-like domain-containing protein.	0.571
A0A1L8ENC4	A0A1L8GPG9	A0A1L8ENC4	A0A1L8GPG9	AAA domain-containing protein.	Uncharacterized protein.	0.868
A0A1L8ENC4	A0A1L8GS29	A0A1L8ENC4	A0A1L8GS29	AAA domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.968
A0A1L8ENC4	A0A1L8H4R2	A0A1L8ENC4	A0A1L8H4R2	AAA domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.774
A0A1L8ENC4	A0A1L8HCZ9	A0A1L8ENC4	A0A1L8HCZ9	AAA domain-containing protein.	Uncharacterized protein.	0.425
A0A1L8ENC4	Dtl.L	A0A1L8ENC4	A0A1L8G665	AAA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.769
A0A1L8ENC4	Meiob.L	A0A1L8ENC4	A0A1L8EYN2	AAA domain-containing protein.	Uncharacterized protein.	0.774
A0A1L8ENC4	Pold1.L	A0A1L8ENC4	A0A1L8FNR6	AAA domain-containing protein.	DNA polymerase.	0.829
A0A1L8ENC4	Pole2.L	A0A1L8ENC4	A0A1L8F9Q8	AAA domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.894
A0A1L8ENC4	Pole4.L	A0A1L8ENC4	A0A1L8GXM8	AAA domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.790
A0A1L8ENC4	Rfc2.L	A0A1L8ENC4	A0A1L8HGA4	AAA domain-containing protein.	AAA domain-containing protein.	0.988
A0A1L8ENC4	Rfc5.S	A0A1L8ENC4	A0A1L8HQV3	AAA domain-containing protein.	AAA domain-containing protein.	0.975
A0A1L8ENC4	Rpa1.L	A0A1L8ENC4	A0A1L8HDB4	AAA domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.774
A0A1L8ENC4	Usp1-b	A0A1L8ENC4	A0A1L8GLJ6	AAA domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.604
A0A1L8ENC4	dtl	A0A1L8ENC4	A0A1L8G1C0	AAA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.769
A0A1L8ENC4	pcna	A0A1L8ENC4	Q9I893	AAA domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.968
A0A1L8ENC4	pold2	A0A1L8ENC4	A0A1L8H1Q8	AAA domain-containing protein.	Uncharacterized protein.	0.754