STRINGSTRING
orc3 orc3 Mcm4.S Mcm4.S mcm6 mcm6 dbf4 dbf4 mcm4 mcm4 chek1-2 chek1-2 chek1 chek1 orc4 orc4 Mcm6.2.L Mcm6.2.L Cdc6.L Cdc6.L Orc2.S Orc2.S Xcdc6 Xcdc6 mcm6.2 mcm6.2 mcm3 mcm3 rad1 rad1 Rad17.L Rad17.L rad9b rad9b cdc45 cdc45 A0A1L8HRA7 A0A1L8HRA7 Rfc5.S Rfc5.S Cdc45.S Cdc45.S Rcbtb1.L Rcbtb1.L Cdk2.L Cdk2.L Rfc2.L Rfc2.L A0A1L8HF97 A0A1L8HF97 Rpa1.L Rpa1.L Rcbtb1.S Rcbtb1.S Cdk2.S Cdk2.S A0A1L8H4R2 A0A1L8H4R2 MCM7 MCM7 mcm10 mcm10 Mcm2.L Mcm2.L Rad26 Rad26 mcm5-2 mcm5-2 A0A1L8GMX9 A0A1L8GMX9 Orc1.L Orc1.L Orc6.L Orc6.L mcm2 mcm2 atrip atrip mcm5 mcm5 zmcm3 zmcm3 Atr.L Atr.L A0A1L8G614 A0A1L8G614 Orc5.L Orc5.L Hus1 Hus1 rad9a rad9a rcbtb2 rcbtb2 rfc5 rfc5 rfc4 rfc4 rpa3-2 rpa3-2 rpa3 rpa3 rfc3 rfc3 Clspn.S Clspn.S
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
orc3ORC_WH_C domain-containing protein. (709 aa)
Mcm4.SDNA helicase; Belongs to the MCM family. (863 aa)
mcm6DNA helicase; Belongs to the MCM family. (821 aa)
dbf4Uncharacterized protein. (661 aa)
mcm4DNA helicase; Belongs to the MCM family. (858 aa)
chek1-2Protein kinase domain-containing protein. (510 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
Mcm6.2.LDNA helicase; Belongs to the MCM family. (823 aa)
Cdc6.LCell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
Orc2.SUncharacterized protein. (558 aa)
Xcdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
mcm6.2DNA helicase; Belongs to the MCM family. (825 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
rad1Uncharacterized protein. (283 aa)
Rad17.LUncharacterized protein. (674 aa)
rad9bCell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa)
cdc45Uncharacterized protein. (567 aa)
A0A1L8HRA7Uncharacterized protein. (177 aa)
Rfc5.SAAA domain-containing protein. (335 aa)
Cdc45.SUncharacterized protein. (580 aa)
Rcbtb1.LBTB domain-containing protein. (600 aa)
Cdk2.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
Rfc2.LAAA domain-containing protein. (359 aa)
A0A1L8HF97Uncharacterized protein. (489 aa)
Rpa1.LReplication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
Rcbtb1.SBTB domain-containing protein. (600 aa)
Cdk2.SProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
A0A1L8H4R2Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa)
mcm10Mcm10 domain-containing protein. (860 aa)
Mcm2.LDNA helicase; Belongs to the MCM family. (886 aa)
Rad26Uncharacterized protein. (798 aa)
mcm5-2DNA helicase; Belongs to the MCM family. (735 aa)
A0A1L8GMX9Protein kinase domain-containing protein. (509 aa)
Orc1.LOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa)
Orc6.LUncharacterized protein. (252 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
atripUncharacterized protein. (801 aa)
mcm5DNA helicase; Belongs to the MCM family. (735 aa)
zmcm3DNA helicase; Belongs to the MCM family. (806 aa)
Atr.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
A0A1L8G614MCM domain-containing protein; Belongs to the MCM family. (798 aa)
Orc5.LAAA_16 domain-containing protein. (440 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
rcbtb2Chc1l-prov protein. (526 aa)
rfc5Rfc5-prov protein. (335 aa)
rfc4Replication factor C p37 subunit. (363 aa)
rpa3-2Rpa3-prov protein. (121 aa)
rpa3LOC495401 protein. (121 aa)
rfc3MGC115007 protein. (356 aa)
Clspn.SClaspin. (1286 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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