77 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	Cass4.S	SH3 domain-containing protein. (858 aa)
	grb2	Uncharacterized protein. (229 aa)
	col6a1	Uncharacterized protein. (1044 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Cass4.L	SH3 domain-containing protein. (853 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	col6a1-2	Uncharacterized protein. (1045 aa)
	pdgfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (202 aa)
	A0A1L8F3B0	Uncharacterized protein. (1205 aa)
	A0A1L8F4B9	Uncharacterized protein. (1020 aa)
	thbs3	Uncharacterized protein. (956 aa)
	Rapgef1.L	N-terminal Ras-GEF domain-containing protein. (157 aa)
	fndc3c	Uncharacterized protein. (1205 aa)
	Thbs2.L	Uncharacterized protein. (1176 aa)
	Thbs3.L	Uncharacterized protein. (964 aa)
	A0A1L8FG16	Uncharacterized protein. (559 aa)
	kras	Uncharacterized protein. (186 aa)
	Nedd9.L	SH3 domain-containing protein. (777 aa)
	sos1	Uncharacterized protein. (1325 aa)
	thbs2	Uncharacterized protein. (1175 aa)
	A0A1L8G3Z7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	fndc3b	Uncharacterized protein. (1205 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	A0A1L8G8D7	Uncharacterized protein. (1174 aa)
	A0A1L8GA65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	fndc3b-2	Uncharacterized protein. (1204 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	bcar1	SH3 domain-containing protein. (947 aa)
	Bcar1.L	SH3 domain-containing protein. (951 aa)
	pdgfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	pdgfrb	Uncharacterized protein. (1074 aa)
	Furin.S	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
	crk	Uncharacterized protein. (297 aa)
	csde1	Uncharacterized protein. (833 aa)
	plat	Plasminogen activator; Belongs to the peptidase S1 family. (566 aa)
	nck2	Cytoplasmic protein. (381 aa)
	A0A1L8H940	Uncharacterized protein. (137 aa)
	A0A1L8H9R9	Signal transducer and activator of transcription. (743 aa)
	fndc3a	Uncharacterized protein. (1202 aa)
	pdgfd	Uncharacterized protein. (389 aa)
	A0A1L8HCC4	Uncharacterized protein. (141 aa)
	Crk.L	Uncharacterized protein. (297 aa)
	nras	Uncharacterized protein. (189 aa)
	A0A1L8HE12	Uncharacterized protein. (122 aa)
	Csde1.L	Uncharacterized protein. (780 aa)
	nck2-2	Cytoplasmic protein. (381 aa)
	Stat6.L	Signal transducer and activator of transcription. (791 aa)
	fndc3a-2	Uncharacterized protein. (1200 aa)
	pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	pdgfc	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (347 aa)
	efs	SH3 domain-containing protein. (649 aa)
	rasa1	Uncharacterized protein. (944 aa)
	pdgfra-2	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
	pdgfc-2	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (347 aa)
	Efs.L	SH3 domain-containing protein. (646 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	Rasa1.L	Uncharacterized protein. (939 aa)
	pdgfa-2	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (200 aa)
	Stat5a	Signal transducer and activator of transcription. (781 aa)
	pcsk4	PC4 protein; Belongs to the peptidase S8 family. (760 aa)
	nck1	Cytoplasmic protein. (377 aa)
	nck1-2	Cytoplasmic protein. (377 aa)
	krasl	Uncharacterized protein. (187 aa)
	furin	LOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
	kras-2	Uncharacterized protein. (187 aa)
	crkl	MGC84382 protein. (302 aa)
	pdgfb-2	Pdgfb protein; Belongs to the PDGF/VEGF growth factor family. (213 aa)
	rapgef1	MGC80732 protein. (1035 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	crkl-2	MGC81407 protein. (302 aa)
	stat5b	Signal transducer and activator of transcription. (781 aa)
	hras	Small G-protein H-Ras. (189 aa)
	kras-3	LOC397771 protein. (186 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKH9	A0A1L8FG16	A0A1L8EKH9	A0A1L8FG16	STAT_int domain-containing protein.	Uncharacterized protein.	0.567
A0A1L8EKH9	A0A1L8H9R9	A0A1L8EKH9	A0A1L8H9R9	STAT_int domain-containing protein.	Signal transducer and activator of transcription.	0.646
A0A1L8EKH9	A0A1L8I158	A0A1L8EKH9	A0A1L8I158	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.567
A0A1L8EKH9	Ptpn11.S	A0A1L8EKH9	Q92124	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	Stat5a	A0A1L8EKH9	B7ZRD3	STAT_int domain-containing protein.	Signal transducer and activator of transcription.	0.611
A0A1L8EKH9	Stat6.L	A0A1L8EKH9	A0A1L8HI20	STAT_int domain-containing protein.	Signal transducer and activator of transcription.	0.645
A0A1L8EKH9	grb2	A0A1L8EKH9	A0A1L8EMZ6	STAT_int domain-containing protein.	Uncharacterized protein.	0.457
A0A1L8EKH9	grb2-2	A0A1L8EKH9	A0A1L8EUF2	STAT_int domain-containing protein.	Uncharacterized protein.	0.457
A0A1L8EKH9	pdgfb	A0A1L8EKH9	A0A1L8GNU7	STAT_int domain-containing protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.452
A0A1L8EKH9	pdgfb-2	A0A1L8EKH9	Q6DDJ9	STAT_int domain-containing protein.	Pdgfb protein; Belongs to the PDGF/VEGF growth factor family.	0.452
A0A1L8EKH9	pdgfra	A0A1L8EKH9	A0A1L8HLA2	STAT_int domain-containing protein.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.652
A0A1L8EKH9	pdgfra-2	A0A1L8EKH9	A0A1L8HTV1	STAT_int domain-containing protein.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.652
A0A1L8EKH9	pdgfrb	A0A1L8EKH9	A0A1L8GR79	STAT_int domain-containing protein.	Uncharacterized protein.	0.683
A0A1L8EKH9	ptpn11b	A0A1L8EKH9	Q6GP31	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	stat5b	A0A1L8EKH9	Q6NU32	STAT_int domain-containing protein.	Signal transducer and activator of transcription.	0.611
A0A1L8F4B9	A0A1L8G8D7	A0A1L8F4B9	A0A1L8G8D7	Uncharacterized protein.	Uncharacterized protein.	0.476
A0A1L8F4B9	col6a1	A0A1L8F4B9	A0A1L8EPE2	Uncharacterized protein.	Uncharacterized protein.	0.416
A0A1L8F4B9	col6a1-2	A0A1L8F4B9	A0A1L8EWI9	Uncharacterized protein.	Uncharacterized protein.	0.416
A0A1L8F4B9	pdgfb	A0A1L8F4B9	A0A1L8GNU7	Uncharacterized protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.493
A0A1L8F4B9	pdgfb-2	A0A1L8F4B9	Q6DDJ9	Uncharacterized protein.	Pdgfb protein; Belongs to the PDGF/VEGF growth factor family.	0.493