38 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8G061	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1305 aa)
	kras-3	LOC397771 protein. (186 aa)
	hras	Small G-protein H-Ras. (189 aa)
	kras-2	Uncharacterized protein. (187 aa)
	krasl	Uncharacterized protein. (187 aa)
	tyrobp	ITAM-bearing signaling subunit. (104 aa)
	Plcg1.S	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	syk	Tyrosine-protein kinase. (605 aa)
	A0A1L8HS58	Uncharacterized protein. (305 aa)
	Syk.S	Tyrosine-protein kinase. (632 aa)
	Csde1.L	Uncharacterized protein. (780 aa)
	A0A1L8HE12	Uncharacterized protein. (122 aa)
	nras	Uncharacterized protein. (189 aa)
	A0A1L8H940	Uncharacterized protein. (137 aa)
	Trem2.S	Ig-like domain-containing protein. (296 aa)
	csde1	Uncharacterized protein. (833 aa)
	A0A1L8H280	MFS domain-containing protein. (498 aa)
	A0A1L8H253	Uncharacterized protein. (341 aa)
	A0A1L8H1I0	Uncharacterized protein. (429 aa)
	A0A1L8H1B9	Uncharacterized protein. (353 aa)
	grb2	Uncharacterized protein. (229 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1280 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	A0A1L8F7B4	Uncharacterized protein. (474 aa)
	kras	Uncharacterized protein. (186 aa)
	A0A1L8FP42	Ig-like domain-containing protein. (424 aa)
	sos1	Uncharacterized protein. (1325 aa)
	A0A1L8G3Z7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	A0A1L8GA65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	A0A1L8GC27	C-type lectin domain-containing protein. (228 aa)
	grap2	Uncharacterized protein. (303 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1259 aa)
	grap2-2	Uncharacterized protein. (301 aa)
	A0A1L8GVE1	SH2 domain-containing protein. (376 aa)
	Lcp2.L	SH2 domain-containing protein. (508 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G061	A0A1L8G3Z7	A0A1L8G061	A0A1L8G3Z7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.764
A0A1L8G061	A0A1L8GVE1	A0A1L8G061	A0A1L8GVE1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	SH2 domain-containing protein.	0.783
A0A1L8G061	Lcp2.L	A0A1L8G061	A0A1L8GXC2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	SH2 domain-containing protein.	0.783
A0A1L8G061	Plcg1.S	A0A1L8G061	A0A310TNX3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.655
A0A1L8G061	Syk.S	A0A1L8G061	A0A1L8HPI7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.705
A0A1L8G061	grap2	A0A1L8G061	A0A1L8GGZ3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.770
A0A1L8G061	grap2-2	A0A1L8G061	A0A1L8GNT4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.770
A0A1L8G061	grb2	A0A1L8G061	A0A1L8EMZ6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.826
A0A1L8G061	grb2-2	A0A1L8G061	A0A1L8EUF2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.826
A0A1L8G061	pik3cb	A0A1L8G061	A0A1L8G4U9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.764
A0A1L8G061	pik3cb-2	A0A1L8G061	A0A1L8GB27	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.764
A0A1L8G061	plcg1	A0A1L8G061	A0A1L8EU11	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.655
A0A1L8G061	plcg2	A0A1L8G061	A0A1L8GKY4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.661
A0A1L8G061	sos1	A0A1L8G061	A0A1L8G1Z8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.570
A0A1L8G061	sos1-2	A0A1L8G061	A0A1L8G7X8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.570
A0A1L8G061	syk	A0A1L8G061	A0A1L8HYI7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.705
A0A1L8G3Z7	A0A1L8G061	A0A1L8G3Z7	A0A1L8G061	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.764
A0A1L8G3Z7	A0A1L8GVE1	A0A1L8G3Z7	A0A1L8GVE1	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	SH2 domain-containing protein.	0.470
A0A1L8G3Z7	A0A1L8H940	A0A1L8G3Z7	A0A1L8H940	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Uncharacterized protein.	0.632
A0A1L8G3Z7	A0A1L8HE12	A0A1L8G3Z7	A0A1L8HE12	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Uncharacterized protein.	0.632