(64 nodes) The canonical retinoid cycle in rods (twilight vision) network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rdh16	MGC68820 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	Rho.L	Rhodopsin. (459 aa)
	dhrs9	Rdhl-prov protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	rdh7	Rodh-A-prov protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	rbp4-2	Rbp4-prov protein; Belongs to the calycin superfamily. Lipocalin family. (197 aa)
	rpe65-2	Rpe65 protein. (533 aa)
	A0A1L8GMV9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	rpe65	Uncharacterized protein. (533 aa)
	Depdc1-b	DEP domain-containing protein. (818 aa)
	A0A1L8GHL0	Rhodopsin. (354 aa)
	A0A1L8GG74	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	A0A1L8GFG2	Rho-GAP domain-containing protein. (595 aa)
	ptchd4	SSD domain-containing protein. (888 aa)
	Rbp1.L	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
	A0A1L8GB51	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2120 aa)
	smpdl3a	Acid sphingomyelinase-like phosphodiesterase. (450 aa)
	A0A1L8G5C4	Uncharacterized protein. (188 aa)
	A0A1L8G5B5	SSD domain-containing protein. (592 aa)
	Rbp1.S	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (170 aa)
	Rdh10.S	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	ttr	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (153 aa)
	A0A1L8FQV3	Uncharacterized protein. (935 aa)
	Rbp3.L	Uncharacterized protein. (1224 aa)
	plekhd1	PH domain-containing protein. (498 aa)
	A0A1L8EYQ5	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (4031 aa)
	A0A1L8EW43	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (353 aa)
	A0A1L8EUI3	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2431 aa)
	A0A1L8ERX7	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
	A0A1L8EQX2	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3851 aa)
	A0A1L8EMY2	Uncharacterized protein. (1767 aa)
	A0A1L8EKR0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
	A0A1L8H9S3	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	ptchd1-2	SSD domain-containing protein. (915 aa)
	Hsd17b6.L	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	Rdh9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	rdh7.2	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	A0A1L8HI07	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
	A0A1L8HI13	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
	A0A1L8HI79	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
	Myo7a.L	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2177 aa)
	A0A1L8HLN1	LRAT domain-containing protein. (228 aa)
	A0A1L8HLN8	LRAT domain-containing protein. (307 aa)
	Cyp4v2.S	Uncharacterized protein; Belongs to the cytochrome P450 family. (522 aa)
	cyp4v2	Uncharacterized protein; Belongs to the cytochrome P450 family. (520 aa)
	A0A1L8HUB1	LRAT domain-containing protein. (227 aa)
	A0A1L8HUF9	LRAT domain-containing protein. (202 aa)
	TTR	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (153 aa)
	rdh5	MGC84099 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	rdh5-2	MGC84134 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	lrat	MGC80134 protein. (228 aa)
	rbp4	LOC397705 protein; Belongs to the calycin superfamily. Lipocalin family. (197 aa)
	MGC68519	MGC68519 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	rlbp1-2	Rlbp1-prov protein. (317 aa)
	Opsin	Rhodopsin. (403 aa)
	rlbp1	CRAL-TRIO domain-containing protein. (317 aa)
	stra6	Uncharacterized protein. (639 aa)
	A0A1L8GTF9	Uncharacterized protein. (645 aa)
	Napepld.S	Lactamase_B domain-containing protein. (470 aa)
	Rdh8.S	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	napepld	Lactamase_B domain-containing protein. (510 aa)
	A0A1L8GZU0	Uncharacterized protein. (509 aa)
	stra6-2	Uncharacterized protein. (639 aa)
	rdh8	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	ptchd1	SSD domain-containing protein. (914 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKR0	Rdh10.S	A0A1L8EKR0	A0A1L8FT95	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.437
A0A1L8GG74	A0A1L8GHL0	A0A1L8GG74	A0A1L8GHL0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Rhodopsin.	0.555
A0A1L8GG74	A0A1L8HLN1	A0A1L8GG74	A0A1L8HLN1	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	LRAT domain-containing protein.	0.715
A0A1L8GG74	A0A1L8HLN8	A0A1L8GG74	A0A1L8HLN8	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	LRAT domain-containing protein.	0.691
A0A1L8GG74	A0A1L8HUB1	A0A1L8GG74	A0A1L8HUB1	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	LRAT domain-containing protein.	0.715
A0A1L8GG74	A0A1L8HUF9	A0A1L8GG74	A0A1L8HUF9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	LRAT domain-containing protein.	0.691
A0A1L8GG74	Opsin	A0A1L8GG74	A0A1L8GPM0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Rhodopsin.	0.554
A0A1L8GG74	Rdh10.S	A0A1L8GG74	A0A1L8FT95	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.409
A0A1L8GG74	Rho.L	A0A1L8GG74	A0A1L8GPJ9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Rhodopsin.	0.452
A0A1L8GG74	lrat	A0A1L8GG74	Q6INW8	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	MGC80134 protein.	0.715
A0A1L8GG74	rdh5	A0A1L8GG74	Q66IY4	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	MGC84099 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.545
A0A1L8GG74	rdh5-2	A0A1L8GG74	Q6GLY2	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	MGC84134 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.548
A0A1L8GG74	rpe65	A0A1L8GG74	A0A1L8GLX0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.514
A0A1L8GG74	rpe65-2	A0A1L8GG74	Q7ZYK2	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Rpe65 protein.	0.509
A0A1L8GHL0	A0A1L8GG74	A0A1L8GHL0	A0A1L8GG74	Rhodopsin.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.555
A0A1L8GHL0	A0A1L8GMV9	A0A1L8GHL0	A0A1L8GMV9	Rhodopsin.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.555
A0A1L8GHL0	Opsin	A0A1L8GHL0	A0A1L8GPM0	Rhodopsin.	Rhodopsin.	0.900
A0A1L8GHL0	Rbp3.L	A0A1L8GHL0	A0A1L8FKR3	Rhodopsin.	Uncharacterized protein.	0.802
A0A1L8GHL0	Rdh8.S	A0A1L8GHL0	A0A1L8GVT0	Rhodopsin.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.555
A0A1L8GHL0	Rho.L	A0A1L8GHL0	A0A1L8GPJ9	Rhodopsin.	Rhodopsin.	0.901