33 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	grb2-2	Uncharacterized protein. (229 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	grb2	Uncharacterized protein. (229 aa)
	A0A1L8FEK1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	A0A1L8FG16	Uncharacterized protein. (559 aa)
	A0A1L8G3Z7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	A0A1L8GA65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	A0A1L8GIQ8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (301 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	fgf6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	Fgf23.2.S	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	fgf23.1	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	fgf6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	Fgf23.2.L	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	fgf23.1-2	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	fgf1-2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf5-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (175 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	Gab1.L	PH domain-containing protein. (682 aa)
	fgf10-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	fgf2-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	gab1	MGC81548 protein. (691 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FEK1	A0A1L8G3Z7	A0A1L8FEK1	A0A1L8G3Z7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.452
A0A1L8FEK1	A0A1L8GA65	A0A1L8FEK1	A0A1L8GA65	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.452
A0A1L8FEK1	A0A1L8GIQ8	A0A1L8FEK1	A0A1L8GIQ8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.692
A0A1L8FEK1	Fgf23.2.L	A0A1L8FEK1	A0A1L8GWG9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Fgf23.2.S	A0A1L8FEK1	A0A1L8GQY9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Frs2.S	A0A1L8FEK1	A0A1L8GUK0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506
A0A1L8FEK1	fgf1	A0A1L8FEK1	A0A1L8GVD8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf1-2	A0A1L8FEK1	A0A1L8GXF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf10	A0A1L8FEK1	A0A1L8I2C9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
A0A1L8FEK1	fgf10-2	A0A1L8FEK1	B5LX82	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
A0A1L8FEK1	fgf22	A0A1L8FEK1	A0A1L8HXE5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
A0A1L8FEK1	fgf23.1	A0A1L8FEK1	A0A1L8GR11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgf23.1-2	A0A1L8FEK1	A0A1L8GWI8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgf3	A0A1L8FEK1	A0A1L8GDM5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.692
A0A1L8FEK1	fgf5	A0A1L8FEK1	A0A1L8HN19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
A0A1L8FEK1	fgf5-2	A0A1L8FEK1	A0A1L8HW95	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
A0A1L8FEK1	frs2	A0A1L8FEK1	A0A1L8GYJ1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506
A0A1L8FEK1	grb2	A0A1L8FEK1	A0A1L8EMZ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.530
A0A1L8FEK1	grb2-2	A0A1L8FEK1	A0A1L8EUF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.530
A0A1L8FG16	A0A1L8G3Z7	A0A1L8FG16	A0A1L8G3Z7	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.646