47 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	grb2	Uncharacterized protein. (229 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	A0A1L8F2F1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	A0A1L8FEK1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	A0A1L8FG16	Uncharacterized protein. (559 aa)
	kras	Uncharacterized protein. (186 aa)
	sos1	Uncharacterized protein. (1325 aa)
	A0A1L8G3Z7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	A0A1L8GA65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	Fgf23.2.S	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	fgf23.1	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	gab1	MGC81548 protein. (691 aa)
	kras-2	Uncharacterized protein. (187 aa)
	krasl	Uncharacterized protein. (187 aa)
	fgf9-A	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	fgf2-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	Gab1.L	PH domain-containing protein. (682 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	fgf5-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Fgfr3.L	Fibroblast growth factor receptor. (821 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	A0A1L8HLD0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	A0A1L8HKQ7	Uncharacterized protein. (925 aa)
	A0A1L8HJ43	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	Csde1.L	Uncharacterized protein. (780 aa)
	A0A1L8HE12	Uncharacterized protein. (122 aa)
	nras	Uncharacterized protein. (189 aa)
	A0A1L8H940	Uncharacterized protein. (137 aa)
	csde1	Uncharacterized protein. (833 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	fgf1-2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	fgf23.1-2	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	Fgf23.2.L	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	kras-3	LOC397771 protein. (186 aa)
	hras	Small G-protein H-Ras. (189 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	frs3	Frs3 protein. (517 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F2F1	A0A1L8HKQ7	A0A1L8F2F1	A0A1L8HKQ7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.599
A0A1L8F2F1	Fgfr3.L	A0A1L8F2F1	A0A1L8HT17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.853
A0A1L8F2F1	grb2	A0A1L8F2F1	A0A1L8EMZ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.458
A0A1L8F2F1	grb2-2	A0A1L8F2F1	A0A1L8EUF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.458
A0A1L8FEK1	A0A1L8G3Z7	A0A1L8FEK1	A0A1L8G3Z7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.452
A0A1L8FEK1	A0A1L8GA65	A0A1L8FEK1	A0A1L8GA65	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.452
A0A1L8FEK1	A0A1L8HKQ7	A0A1L8FEK1	A0A1L8HKQ7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.823
A0A1L8FEK1	Fgf23.2.L	A0A1L8FEK1	A0A1L8GWG9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Fgf23.2.S	A0A1L8FEK1	A0A1L8GQY9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Fgfr3.L	A0A1L8FEK1	A0A1L8HT17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.823
A0A1L8FEK1	Frs2.S	A0A1L8FEK1	A0A1L8GUK0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506
A0A1L8FEK1	fgf1	A0A1L8FEK1	A0A1L8GVD8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf1-2	A0A1L8FEK1	A0A1L8GXF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf23.1	A0A1L8FEK1	A0A1L8GR11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgf23.1-2	A0A1L8FEK1	A0A1L8GWI8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgf5	A0A1L8FEK1	A0A1L8HN19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
A0A1L8FEK1	fgf5-2	A0A1L8FEK1	A0A1L8HW95	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
A0A1L8FEK1	frs2	A0A1L8FEK1	A0A1L8GYJ1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506
A0A1L8FEK1	frs3	A0A1L8FEK1	Q6IR73	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Frs3 protein.	0.497
A0A1L8FEK1	grb2	A0A1L8FEK1	A0A1L8EMZ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.530