56 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fgf23.2.L	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	A0A1L8F2F1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	A0A1L8F3B0	Uncharacterized protein. (1205 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	fndc3c	Uncharacterized protein. (1205 aa)
	A0A1L8FEK1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	mknk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	A0A1L8FG16	Uncharacterized protein. (559 aa)
	A0A1L8FTA7	Ubiquitin-like domain-containing protein. (105 aa)
	fndc3b	Uncharacterized protein. (1205 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	A0A1L8HX68	Ubiquitin-like domain-containing protein. (173 aa)
	mknk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
	ubc	Uncharacterized protein. (533 aa)
	A0A1L8HNG1	Protein kinase domain-containing protein. (409 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	A0A1L8HLD0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	A0A1L8HJ43	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	fndc3a-2	Uncharacterized protein. (1200 aa)
	spry2	Uncharacterized protein. (307 aa)
	A0A1L8G5V1	Ubiquitin-like domain-containing protein. (156 aa)
	fndc3b-2	Uncharacterized protein. (1204 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	A0A1L8HCZ9	Uncharacterized protein. (307 aa)
	fndc3a	Uncharacterized protein. (1202 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	fgfr4	Fibroblast growth factor receptor. (807 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	fgf1-2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	fgf23.1-2	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	spry2-2	LOC398313 protein. (314 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	ubc-2	Ubc-prov protein. (609 aa)
	uba52	MGC80109 protein. (128 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	rps27a	MGC81889 protein. (156 aa)
	fgf9-A	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	fgf2-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	grb2	Uncharacterized protein. (229 aa)
	fgf19-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	A0A1L8GM97	Protein kinase domain-containing protein. (426 aa)
	A0A1L8GQL8	Serine/threonine-protein phosphatase. (225 aa)
	braf	Uncharacterized protein. (802 aa)
	fgf6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	Fgf23.2.S	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (256 aa)
	fgf23.1	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (244 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	Fgfr4.S	Fibroblast growth factor receptor. (825 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	fgf6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F2F1	A0A1L8G5V1	A0A1L8F2F1	A0A1L8G5V1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin-like domain-containing protein.	0.439
A0A1L8F2F1	Fgfr4.S	A0A1L8F2F1	A0A1L8GV41	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.858
A0A1L8F2F1	fgfr4	A0A1L8F2F1	A0A1L8GXW6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.858
A0A1L8F2F1	grb2	A0A1L8F2F1	A0A1L8EMZ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.458
A0A1L8F2F1	grb2-2	A0A1L8F2F1	A0A1L8EUF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.458
A0A1L8F2F1	rps27a	A0A1L8F2F1	Q6GMC1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	MGC81889 protein.	0.439
A0A1L8FEK1	A0A1L8G5V1	A0A1L8FEK1	A0A1L8G5V1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin-like domain-containing protein.	0.557
A0A1L8FEK1	A0A1L8HCZ9	A0A1L8FEK1	A0A1L8HCZ9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.497
A0A1L8FEK1	Fgf23.2.L	A0A1L8FEK1	A0A1L8GWG9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Fgf23.2.S	A0A1L8FEK1	A0A1L8GQY9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	Fgfr4.S	A0A1L8FEK1	A0A1L8GV41	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.834
A0A1L8FEK1	Frs2.S	A0A1L8FEK1	A0A1L8GUK0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506
A0A1L8FEK1	fgf1	A0A1L8FEK1	A0A1L8GVD8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf1-2	A0A1L8FEK1	A0A1L8GXF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.431
A0A1L8FEK1	fgf19	A0A1L8FEK1	A0A1L8GDL8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
A0A1L8FEK1	fgf19-2	A0A1L8FEK1	A0A1L8GIT6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
A0A1L8FEK1	fgf23.1	A0A1L8FEK1	A0A1L8GR11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgf23.1-2	A0A1L8FEK1	A0A1L8GWI8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.538
A0A1L8FEK1	fgfr4	A0A1L8FEK1	A0A1L8GXW6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.834
A0A1L8FEK1	frs2	A0A1L8FEK1	A0A1L8GYJ1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	IRS-type PTB domain-containing protein.	0.506