STRINGSTRING
A0A1L8GSW6 A0A1L8GSW6 dclre1c dclre1c A0A1L8GU05 A0A1L8GU05 Ube2n.S Ube2n.S rad50 rad50 rad50-2 rad50-2 A0A1L8GY09 A0A1L8GY09 ube2n ube2n A0A1L8GZK5 A0A1L8GZK5 tp53bp1 tp53bp1 A0A1L8H8N4 A0A1L8H8N4 A0A1L8HBA4 A0A1L8HBA4 rnf169 rnf169 A0A1L8HGP5 A0A1L8HGP5 mre11 mre11 rnf169-2 rnf169-2 Nsd2.S Nsd2.S A0A1L8HMW1 A0A1L8HMW1 Pias4.S Pias4.S abraxas1 abraxas1 A0A1L8HRF5 A0A1L8HRF5 nsd2 nsd2 A0A1L8HTB6 A0A1L8HTB6 A0A1L8HVY7 A0A1L8HVY7 Pias4.L Pias4.L babam1 babam1 A0A1L8I1K3 A0A1L8I1K3 A0A1L8I1T7 A0A1L8I1T7 A0A310TK05 A0A310TK05 A0A310TM08 A0A310TM08 A0A310TM74 A0A310TM74 A0A310TML1 A0A310TML1 A0A310TNN0 A0A310TNN0 A0A310U368 A0A310U368 Hist1h4d.L Hist1h4d.L A0A310U9I4 A0A310U9I4 lig4 lig4 H2B H2B slc23a3 slc23a3 nhej1 nhej1 A0A1L8ENU1 A0A1L8ENU1 A0A1L8ENW3 A0A1L8ENW3 rif1 rif1 A0A1L8EPM6 A0A1L8EPM6 Brca1.L Brca1.L Xrcc5.L Xrcc5.L cnppd1 cnppd1 A0A1L8EVP6 A0A1L8EVP6 A0A1L8EVW9 A0A1L8EVW9 bard1 bard1 A0A1L8F2E2 A0A1L8F2E2 A0A1L8F335 A0A1L8F335 brcc3 brcc3 tmem182 tmem182 mdc1 mdc1 Tdp1.L Tdp1.L dntt dntt poll poll A0A1L8FPV0 A0A1L8FPV0 A0A1L8FQ56 A0A1L8FQ56 A0A1L8FQA5 A0A1L8FQA5 paxip1 paxip1 Tdp2.S Tdp2.S ankrd12 ankrd12 A0A1L8FSQ8 A0A1L8FSQ8 ube2v2 ube2v2 Paxip1.L Paxip1.L A0A1L8FW69 A0A1L8FW69 A0A1L8FXP8 A0A1L8FXP8 ankrd12-2 ankrd12-2 A0A1L8FYX8 A0A1L8FYX8 Prkdc.L Prkdc.L Nbn.L Nbn.L hist1h4a hist1h4a H2B-2 H2B-2 rnf8 rnf8 rnf168 rnf168 A0A1L8G6R5 A0A1L8G6R5 A0A1L8G6S1 A0A1L8G6S1 Bre.L Bre.L RNF8 RNF8 A0A1L8G6Z0 A0A1L8G6Z0 A0A1L8G784 A0A1L8G784 A0A1L8G795 A0A1L8G795 A0A1L8G869 A0A1L8G869 rnf168-2 rnf168-2 ankrd11 ankrd11 A0A1L8GHN7 A0A1L8GHN7 A0A1L8GKR7 A0A1L8GKR7 Xrcc6.L Xrcc6.L A0A1L8GS64 A0A1L8GS64
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1L8GSW6Uncharacterized protein. (2175 aa)
dclre1cUncharacterized protein. (698 aa)
A0A1L8GU05Uncharacterized protein. (291 aa)
Ube2n.SUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
A0A1L8GY09RAP80_UIM domain-containing protein. (937 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
A0A1L8GZK5Uncharacterized protein. (348 aa)
tp53bp1Uncharacterized protein. (2179 aa)
A0A1L8H8N4Uncharacterized protein. (235 aa)
A0A1L8HBA4Uncharacterized protein. (103 aa)
rnf169Uncharacterized protein. (483 aa)
A0A1L8HGP5Uncharacterized protein. (235 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
rnf169-2Uncharacterized protein. (496 aa)
Nsd2.SUncharacterized protein. (1300 aa)
A0A1L8HMW1Uncharacterized protein. (149 aa)
Pias4.SUncharacterized protein. (543 aa)
abraxas1MPN domain-containing protein. (408 aa)
A0A1L8HRF5Uncharacterized protein. (426 aa)
nsd2Uncharacterized protein. (1300 aa)
A0A1L8HTB6Uncharacterized protein. (198 aa)
A0A1L8HVY7Uncharacterized protein. (326 aa)
Pias4.LUncharacterized protein. (544 aa)
babam1Uncharacterized protein. (328 aa)
A0A1L8I1K3Uncharacterized protein. (275 aa)
A0A1L8I1T7Uncharacterized protein. (335 aa)
A0A310TK05Uncharacterized protein. (188 aa)
A0A310TM08Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A310TM74Uncharacterized protein. (104 aa)
A0A310TML1CENP-T_C domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (43 aa)
A0A310TNN0Uncharacterized protein. (183 aa)
A0A310U368Histone H2B; Belongs to the histone H2B family. (94 aa)
Hist1h4d.LHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A310U9I4Uncharacterized protein. (485 aa)
lig4DNA ligase. (911 aa)
H2BHistone H2B; Belongs to the histone H2B family. (126 aa)
slc23a3Uncharacterized protein. (599 aa)
nhej1Uncharacterized protein. (362 aa)
A0A1L8ENU1Uncharacterized protein; Belongs to the histone H2B family. (98 aa)
A0A1L8ENW3Uncharacterized protein. (453 aa)
rif1Rif1_N domain-containing protein. (2326 aa)
A0A1L8EPM6ANK_REP_REGION domain-containing protein. (400 aa)
Brca1.LUncharacterized protein. (1582 aa)
Xrcc5.LX-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa)
cnppd1Uncharacterized protein. (455 aa)
A0A1L8EVP6Uncharacterized protein. (289 aa)
A0A1L8EVW9Uncharacterized protein; Belongs to the histone H2B family. (98 aa)
bard1Uncharacterized protein. (839 aa)
A0A1L8F2E2Uncharacterized protein. (308 aa)
A0A1L8F335Uncharacterized protein. (240 aa)
brcc3MPN domain-containing protein. (261 aa)
tmem182Uncharacterized protein. (240 aa)
mdc1Uncharacterized protein. (2103 aa)
Tdp1.LUncharacterized protein. (597 aa)
dnttDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (507 aa)
pollBRCT domain-containing protein; Belongs to the DNA polymerase type-X family. (577 aa)
A0A1L8FPV0Uncharacterized protein. (145 aa)
A0A1L8FQ56Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A1L8FQA5Histone H2B; Belongs to the histone H2B family. (126 aa)
paxip1Uncharacterized protein. (1334 aa)
Tdp2.SEndo/exonuclease/phosphatase domain-containing protein. (382 aa)
ankrd12ANK_REP_REGION domain-containing protein. (1985 aa)
A0A1L8FSQ8Uncharacterized protein. (127 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
Paxip1.LUncharacterized protein. (1320 aa)
A0A1L8FW69Uncharacterized protein. (279 aa)
A0A1L8FXP8Uncharacterized protein. (349 aa)
ankrd12-2ANK_REP_REGION domain-containing protein. (1961 aa)
A0A1L8FYX8UBIQUITIN_CONJUGAT_2 domain-containing protein. (137 aa)
Prkdc.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
Nbn.LNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
hist1h4aHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2B-2Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa)
A0A1L8G6R5Histone H2B; Belongs to the histone H2B family. (347 aa)
A0A1L8G6S1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa)
Bre.LUncharacterized protein. (404 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
A0A1L8G6Z0Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A1L8G784Uncharacterized protein. (171 aa)
A0A1L8G795Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A1L8G869Uncharacterized protein. (166 aa)
rnf168-2E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2741 aa)
A0A1L8GHN7Uncharacterized protein. (175 aa)
A0A1L8GKR7Uncharacterized protein. (120 aa)
Xrcc6.LKu domain-containing protein. (611 aa)
A0A1L8GS64DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (604 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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