Your Input: | |
| | H2B | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A1L8HHZ4 | Uncharacterized protein. (1214 aa) |
| | Rcbtb1.L | BTB domain-containing protein. (600 aa) |
| | Ccna1.L | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (421 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa) |
| | rnf169-2 | Uncharacterized protein. (496 aa) |
| | Nsd2.S | Uncharacterized protein. (1300 aa) |
| | Ccna2.S | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa) |
| | A0A1L8EPM6 | ANK_REP_REGION domain-containing protein. (400 aa) |
| | ube2i | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | Brca1.L | Uncharacterized protein. (1582 aa) |
| | bard1 | Uncharacterized protein. (839 aa) |
| | rmi2 | Uncharacterized protein. (152 aa) |
| | A0A1L8EXX7 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa) |
| | A0A1L8F2E2 | Uncharacterized protein. (308 aa) |
| | Exo1.S | Uncharacterized protein. (734 aa) |
| | brcc3 | MPN domain-containing protein. (261 aa) |
| | Dna2.S | Uncharacterized protein. (1053 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa) |
| | chek1-2 | Protein kinase domain-containing protein. (510 aa) |
| | A0A1L8FPV0 | Uncharacterized protein. (145 aa) |
| | A0A1L8FQ56 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A1L8FQA5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (1985 aa) |
| | A0A1L8FSQ8 | Uncharacterized protein. (127 aa) |
| | rbbp8 | Uncharacterized protein. (846 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | A0A1L8FW69 | Uncharacterized protein. (279 aa) |
| | topbp1 | Uncharacterized protein. (1573 aa) |
| | A0A1L8HMW1 | Uncharacterized protein. (149 aa) |
| | A0A1L8FXP8 | Uncharacterized protein. (349 aa) |
| | ankrd12-2 | ANK_REP_REGION domain-containing protein. (1961 aa) |
| | Rbbp8.L | Uncharacterized protein. (856 aa) |
| | A0A1L8FYX8 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (137 aa) |
| | Nbn.L | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa) |
| | hist1h4a | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H2B-2 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa) |
| | A0A1L8G6R5 | Histone H2B; Belongs to the histone H2B family. (347 aa) |
| | A0A1L8G6S1 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa) |
| | Bre.L | Uncharacterized protein. (404 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa) |
| | A0A1L8G6Z0 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | A0A1L8G795 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A1L8G869 | Uncharacterized protein. (166 aa) |
| | Atr.L | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa) |
| | rnf168-2 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa) |
| | ankrd11 | ANK_REP_REGION domain-containing protein. (2741 aa) |
| | atrip | Uncharacterized protein. (801 aa) |
| | A0A1L8GHN7 | Uncharacterized protein. (175 aa) |
| | ppp4r2 | Uncharacterized protein. (398 aa) |
| | A0A1L8GKR7 | Uncharacterized protein. (120 aa) |
| | Rad26 | Uncharacterized protein. (798 aa) |
| | Ppp4r2.L | Uncharacterized protein. (403 aa) |
| | Rhno1.S | Uncharacterized protein. (252 aa) |
| | blm | Uncharacterized protein. (1368 aa) |
| | Tipin.S | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa) |
| | A0A1L8GSW6 | Uncharacterized protein. (2175 aa) |
| | A0A1L8GU05 | Uncharacterized protein. (291 aa) |
| | Ube2n.S | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1311 aa) |
| | A0A1L8GWA8 | Uncharacterized protein. (209 aa) |
| | rad50-2 | Zinc-hook domain-containing protein. (1312 aa) |
| | A0A1L8GY09 | RAP80_UIM domain-containing protein. (937 aa) |
| | ube2n | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | A0A1L8GZK5 | Uncharacterized protein. (348 aa) |
| | tp53bp1 | Uncharacterized protein. (2179 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa) |
| | A0A1L8H1D5 | Uncharacterized protein. (1367 aa) |
| | A0A1L8H4R2 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa) |
| | Cdk2.S | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | A0A1L8H9R2 | Uncharacterized protein. (1288 aa) |
| | Rcbtb1.S | BTB domain-containing protein. (600 aa) |
| | Ccna1.S | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (418 aa) |
| | A0A1L8HBA4 | Uncharacterized protein. (103 aa) |
| | rnf169 | Uncharacterized protein. (483 aa) |
| | Recql4.L | Uncharacterized protein. (1504 aa) |
| | Rpa1.L | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa) |
| | Rfc2.L | AAA domain-containing protein. (359 aa) |
| | Cdk2.L | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | Pias4.S | Uncharacterized protein. (543 aa) |
| | A0A1L8HPD7 | Uncharacterized protein. (341 aa) |
| | abraxas1 | MPN domain-containing protein. (408 aa) |
| | Rfc5.S | AAA domain-containing protein. (335 aa) |
| | A0A1L8HRA7 | Uncharacterized protein. (177 aa) |
| | A0A1L8HRF5 | Uncharacterized protein. (426 aa) |
| | nsd2 | Uncharacterized protein. (1300 aa) |
| | A0A1L8HTB6 | Uncharacterized protein. (198 aa) |
| | A0A1L8HVY7 | Uncharacterized protein. (326 aa) |
| | Pias4.L | Uncharacterized protein. (544 aa) |
| | wrn | Uncharacterized protein. (1434 aa) |
| | babam1 | Uncharacterized protein. (328 aa) |
| | A0A1L8HYF4 | DUF1767 domain-containing protein. (512 aa) |
| | rad9b | Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa) |
| | A0A1L8I1K3 | Uncharacterized protein. (275 aa) |
| | Rad17.L | Uncharacterized protein. (674 aa) |
| | rad1 | Uncharacterized protein. (283 aa) |
| | A0A310TK05 | Uncharacterized protein. (188 aa) |
| | A0A310TM08 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A310TM74 | Uncharacterized protein. (104 aa) |
| | A0A310TML1 | CENP-T_C domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (43 aa) |
| | A0A310TNN0 | Uncharacterized protein. (183 aa) |
| | A0A310U368 | Histone H2B; Belongs to the histone H2B family. (94 aa) |
| | Hist1h4d.L | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | A0A310U9I4 | Uncharacterized protein. (485 aa) |
| | LOC100037190 | LOC100037190 protein. (331 aa) |
| | ccna2 | MGC130969 protein; Belongs to the cyclin family. (415 aa) |
| | rfc3 | MGC115007 protein. (356 aa) |
| | rpa3 | LOC495401 protein. (121 aa) |
| | rpa3-2 | Rpa3-prov protein. (121 aa) |
| | sirt6 | MGC82564 protein. (331 aa) |
| | rfc4 | Replication factor C p37 subunit. (363 aa) |
| | rfc5 | Rfc5-prov protein. (335 aa) |
| | rcbtb2 | Chc1l-prov protein. (526 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa) |
| | Hus1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
