STRINGSTRING
Mcm6.2.L Mcm6.2.L A0A1L8G3T0 A0A1L8G3T0 Psmd2.S Psmd2.S orc3 orc3 fam89a fam89a anapc1 anapc1 H2B-2 H2B-2 hist1h4a hist1h4a Orc5.L Orc5.L Mcm4.S Mcm4.S Gmnn.L Gmnn.L mcm6 mcm6 anapc15 anapc15 A0A1L8FTA7 A0A1L8FTA7 mcm4 mcm4 psma2 psma2 Anapc15-a Anapc15-a A0A1L8G784 A0A1L8G784 A0A1L8G795 A0A1L8G795 fam89a-2 fam89a-2 mcm9 mcm9 Psmd2.L Psmd2.L A0A1L8GBH4 A0A1L8GBH4 zmcm3 zmcm3 Psmd13.S Psmd13.S Psma1.S Psma1.S psmd7 psmd7 Cdt1.S Cdt1.S mcm5 mcm5 mcm2 mcm2 A0A1L8GI18 A0A1L8GI18 Orc6.L Orc6.L A0A1L8GLZ6 A0A1L8GLZ6 Orc1.L Orc1.L A0A1L8GN61 A0A1L8GN61 mcm5-2 mcm5-2 Mcm2.L Mcm2.L A0A1L8GQD1 A0A1L8GQD1 A0A1L8GRZ1 A0A1L8GRZ1 psmc2 psmc2 cdc23 cdc23 Cdc23.L Cdc23.L H2afv.S H2afv.S MCM7 MCM7 A0A1L8H5K7 A0A1L8H5K7 Psmb2.S Psmb2.S Kpna6.S Kpna6.S A0A1L8HB55 A0A1L8HB55 A0A1L8HBW3 A0A1L8HBW3 A0A1L8HCZ9 A0A1L8HCZ9 h2afz h2afz kxd1 kxd1 Psme1.S Psme1.S A0A1L8HPK4 A0A1L8HPK4 psmb5 psmb5 ubc ubc anapc4 anapc4 Fzr1.L Fzr1.L A0A1L8HVW6 A0A1L8HVW6 Kxd1.L Kxd1.L A0A1L8HX68 A0A1L8HX68 psmb5-2 psmb5-2 Anapc5.L Anapc5.L A0A310TM08 A0A310TM08 A0A1L8FQA5 A0A1L8FQA5 A0A1L8FQ56 A0A1L8FQ56 ube2s-2 ube2s-2 anapc16-2 anapc16-2 A0A1L8FHT9 A0A1L8FHT9 A0A1L8FHT5 A0A1L8FHT5 A0A1L8FHS4 A0A1L8FHS4 ube2s ube2s anapc16 anapc16 A0A1L8FDD6 A0A1L8FDD6 Psmb4.L Psmb4.L psmc6 psmc6 Psmc1.L Psmc1.L Psmd8.L Psmd8.L psmb7 psmb7 psmd5 psmd5 cdc26 cdc26 A0A310TMH3 A0A310TMH3 A0A310TML1 A0A310TML1 A0A310TNW1 A0A310TNW1 A0A310U368 A0A310U368 Hist1h4d.L Hist1h4d.L psmc2-2 psmc2-2 psmc3-a psmc3-a gmnn gmnn psmb6 psmb6 psma1 psma1 anapc10 anapc10 anapc10-2 anapc10-2 ube2c-2 ube2c-2 Psmb3 Psmb3 psmb3 psmb3 psmd10 psmd10 psmf1 psmf1 psme3 psme3 psme1 psme1 anapc7 anapc7 psmd7-2 psmd7-2 psmb7-2 psmb7-2 psma6 psma6 anapc7-2 anapc7-2 cdc16 cdc16 psmd9 psmd9 psme2 psme2 rps27a rps27a psma5 psma5 psmb2 psmb2 psmc5-2 psmc5-2 H2B H2B psmb8 psmb8 psma3 psma3 anapc2 anapc2 A0A1L8F5A2 A0A1L8F5A2 psmb4 psmb4 Psmd8.S Psmd8.S Psmb9.S Psmb9.S A0A1L8F3K4 A0A1L8F3K4 Psmd10.S Psmd10.S A0A1L8F0S4 A0A1L8F0S4 psmc1 psmc1 Psmc6.S Psmc6.S A0A1L8EZW5 A0A1L8EZW5 A0A1L8EZQ1 A0A1L8EZQ1 A0A1L8EVW9 A0A1L8EVW9 orc4 orc4 A0A1L8G5V1 A0A1L8G5V1 Psmd12.L Psmd12.L ube2c ube2c Anapc11.L Anapc11.L cdc27-2 cdc27-2 psmd11-2 psmd11-2 Cdc6.L Cdc6.L A0A1L8ERZ6 A0A1L8ERZ6 psmd3 psmd3 Orc2.S Orc2.S A0A1L8ENU1 A0A1L8ENU1 Psmd12.S Psmd12.S cdc27 cdc27 psmc5 psmc5 psmd11 psmd11 Psmd3.S Psmd3.S A0A1L8EKT2 A0A1L8EKT2 Xcdc6 Xcdc6 mcm6.2 mcm6.2 mcm3 mcm3 uba52 uba52 A0A1L8G6Z0 A0A1L8G6Z0 psme3-2 psme3-2 Q70PC5_XENLA Q70PC5_XENLA ubc-2 ubc-2 psmb7.2 psmb7.2 psma4 psma4 psmc3 psmc3 psmd14 psmd14 psmd6 psmd6 psmb1 psmb1 psmd9-2 psmd9-2 A0A1L8G6S1 A0A1L8G6S1 A0A1L8G6R5 A0A1L8G6R5 A0A1L8G614 A0A1L8G614
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mcm6.2.LDNA helicase; Belongs to the MCM family. (823 aa)
A0A1L8G3T026S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (922 aa)
Psmd2.S26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
orc3ORC_WH_C domain-containing protein. (709 aa)
fam89aUncharacterized protein. (166 aa)
anapc1APC1_C domain-containing protein. (1948 aa)
H2B-2Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
hist1h4aHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Orc5.LAAA_16 domain-containing protein. (440 aa)
Mcm4.SDNA helicase; Belongs to the MCM family. (863 aa)
Gmnn.LUncharacterized protein. (213 aa)
mcm6DNA helicase; Belongs to the MCM family. (821 aa)
anapc15Uncharacterized protein. (120 aa)
A0A1L8FTA7Ubiquitin-like domain-containing protein. (105 aa)
mcm4DNA helicase; Belongs to the MCM family. (858 aa)
psma2Proteasome subunit alpha type. (234 aa)
Anapc15-aUncharacterized protein. (120 aa)
A0A1L8G784Uncharacterized protein. (171 aa)
A0A1L8G795Histone H2B; Belongs to the histone H2B family. (126 aa)
fam89a-2Uncharacterized protein. (166 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1143 aa)
Psmd2.L26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
A0A1L8GBH4Uncharacterized protein. (148 aa)
zmcm3DNA helicase; Belongs to the MCM family. (806 aa)
Psmd13.SPCI domain-containing protein. (364 aa)
Psma1.SProteasome subunit alpha type. (295 aa)
psmd7MPN domain-containing protein. (320 aa)
Cdt1.SCDT1 domain-containing protein. (615 aa)
mcm5DNA helicase; Belongs to the MCM family. (735 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
A0A1L8GI18Uncharacterized protein. (364 aa)
Orc6.LUncharacterized protein. (252 aa)
A0A1L8GLZ6Proteasome subunit alpha type. (261 aa)
Orc1.LOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa)
A0A1L8GN61Uncharacterized protein. (244 aa)
mcm5-2DNA helicase; Belongs to the MCM family. (735 aa)
Mcm2.LDNA helicase; Belongs to the MCM family. (886 aa)
A0A1L8GQD1DUF4203 domain-containing protein. (566 aa)
A0A1L8GRZ1Histone H2A; Belongs to the histone H2A family. (221 aa)
psmc2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
cdc23TPR_REGION domain-containing protein. (581 aa)
Cdc23.LTPR_REGION domain-containing protein. (580 aa)
H2afv.SHistone H2A; Belongs to the histone H2A family. (234 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa)
A0A1L8H5K7Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
Psmb2.SProteasome subunit beta. (199 aa)
Kpna6.SImportin subunit alpha; Belongs to the importin alpha family. (534 aa)
A0A1L8HB55BZIP domain-containing protein. (304 aa)
A0A1L8HBW3Importin subunit alpha; Belongs to the importin alpha family. (539 aa)
A0A1L8HCZ9Uncharacterized protein. (307 aa)
h2afzHistone H2A; Belongs to the histone H2A family. (128 aa)
kxd1KxDL domain-containing protein. (195 aa)
Psme1.SUncharacterized protein. (244 aa)
A0A1L8HPK4Uncharacterized protein. (256 aa)
psmb5Proteasome subunit beta. (257 aa)
ubcUncharacterized protein. (533 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (789 aa)
Fzr1.LWD_REPEATS_REGION domain-containing protein. (251 aa)
A0A1L8HVW6WD_REPEATS_REGION domain-containing protein. (218 aa)
Kxd1.LKxDL domain-containing protein. (195 aa)
A0A1L8HX68Ubiquitin-like domain-containing protein. (173 aa)
psmb5-2Proteasome subunit beta. (257 aa)
Anapc5.LUncharacterized protein. (759 aa)
A0A310TM08Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A1L8FQA5Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A1L8FQ56Histone H2B; Belongs to the histone H2B family. (126 aa)
ube2s-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
anapc16-2Uncharacterized protein. (144 aa)
A0A1L8FHT9Uncharacterized protein. (94 aa)
A0A1L8FHT5AAA domain-containing protein. (240 aa)
A0A1L8FHS4Prot_ATP_ID_OB domain-containing protein. (59 aa)
ube2sUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
anapc16Uncharacterized protein. (144 aa)
A0A1L8FDD6VWFA domain-containing protein. (377 aa)
Psmb4.LProteasome subunit beta; Belongs to the peptidase T1B family. (249 aa)
psmc6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
Psmc1.LAAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
Psmd8.LPCI domain-containing protein. (271 aa)
psmb7Proteasome subunit beta. (277 aa)
psmd5Uncharacterized protein. (505 aa)
cdc26Uncharacterized protein. (84 aa)
A0A310TMH3DUF4203 domain-containing protein. (227 aa)
A0A310TML1CENP-T_C domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (43 aa)
A0A310TNW1Prot_ATP_ID_OB domain-containing protein. (153 aa)
A0A310U368Histone H2B; Belongs to the histone H2B family. (94 aa)
Hist1h4d.LHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
psmc2-2XMSS1 protein; Belongs to the AAA ATPase family. (433 aa)
psmc3-a26S proteasome regulatory subunit 6A-A; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (423 aa)
gmnnGMNN protein. (219 aa)
psmb6Proteasome subunit beta. (233 aa)
psma1Proteasome subunit alpha type. (261 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
anapc10-2Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ube2c-2LOC496302 protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Psmb3Proteasome subunit beta. (205 aa)
psmb3Proteasome subunit beta. (205 aa)
psmd10LOC495968 protein. (227 aa)
psmf1LOC495127 protein. (263 aa)
psme3Psme3b protein. (254 aa)
psme1LOC494646 protein. (244 aa)
anapc7MGC81861 protein. (565 aa)
psmd7-2MGC84052 protein. (320 aa)
psmb7-2Proteasome subunit beta. (277 aa)
psma6Proteasome subunit alpha type. (246 aa)
anapc7-2Anapc7-prov protein. (565 aa)
cdc16Cdc16-prov protein. (621 aa)
psmd9MGC84770 protein. (208 aa)
psme2MGC84168 protein. (242 aa)
rps27aMGC81889 protein. (156 aa)
psma5Proteasome subunit alpha type. (247 aa)
psmb2Proteasome subunit beta. (199 aa)
psmc5-2MGC80185 protein; Belongs to the AAA ATPase family. (415 aa)
H2BHistone H2B; Belongs to the histone H2B family. (126 aa)
psmb8Proteasome subunit beta. (271 aa)
psma3Proteasome subunit alpha type. (255 aa)
anapc2CULLIN_2 domain-containing protein; Belongs to the cullin family. (810 aa)
A0A1L8F5A2VWFA domain-containing protein. (635 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (249 aa)
Psmd8.SPCI domain-containing protein. (271 aa)
Psmb9.SProteasome subunit beta. (215 aa)
A0A1L8F3K4Proteasome subunit beta. (279 aa)
Psmd10.SANK_REP_REGION domain-containing protein. (270 aa)
A0A1L8F0S4Uncharacterized protein. (84 aa)
psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
Psmc6.SAAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
A0A1L8EZW5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (352 aa)
A0A1L8EZQ1Proteasome subunit alpha type. (236 aa)
A0A1L8EVW9Uncharacterized protein; Belongs to the histone H2B family. (98 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
A0A1L8G5V1Ubiquitin-like domain-containing protein. (156 aa)
Psmd12.LPCI domain-containing protein. (455 aa)
ube2cUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Anapc11.LRING-type domain-containing protein. (143 aa)
cdc27-2Uncharacterized protein. (834 aa)
psmd11-2PCI domain-containing protein. (422 aa)
Cdc6.LCell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
A0A1L8ERZ6Importin N-terminal domain-containing protein. (871 aa)
psmd3PCI domain-containing protein. (547 aa)
Orc2.SUncharacterized protein. (558 aa)
A0A1L8ENU1Uncharacterized protein; Belongs to the histone H2B family. (98 aa)
Psmd12.SPCI domain-containing protein. (455 aa)
cdc27Uncharacterized protein. (833 aa)
psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
psmd11PCI domain-containing protein. (422 aa)
Psmd3.SPCI domain-containing protein. (498 aa)
A0A1L8EKT2Importin N-terminal domain-containing protein. (1129 aa)
Xcdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
mcm6.2DNA helicase; Belongs to the MCM family. (825 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
uba52MGC80109 protein. (128 aa)
A0A1L8G6Z0Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
psme3-2Psme3 protein. (254 aa)
Q70PC5_XENLAImportin subunit alpha; Belongs to the importin alpha family. (537 aa)
ubc-2Ubc-prov protein. (609 aa)
psmb7.2Proteasome subunit beta. (279 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmc3Psmc3-b protein; Belongs to the AAA ATPase family. (423 aa)
psmd14Psmd14-prov protein. (310 aa)
psmd6P44s10-prov protein. (389 aa)
psmb1Proteasome subunit beta. (239 aa)
psmd9-2MGC53232 protein. (213 aa)
A0A1L8G6S1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa)
A0A1L8G6R5Histone H2B; Belongs to the histone H2B family. (347 aa)
A0A1L8G614MCM domain-containing protein; Belongs to the MCM family. (798 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (18%) [HD]