Your Input: | |
| | A0A1L8GN61 | Uncharacterized protein. (244 aa) |
| | mcm5-2 | DNA helicase; Belongs to the MCM family. (735 aa) |
| | Rad26 | Uncharacterized protein. (798 aa) |
| | Mcm2.L | DNA helicase; Belongs to the MCM family. (886 aa) |
| | Wee2 | Wee1-like protein kinase. (534 aa) |
| | Rhno1.S | Uncharacterized protein. (252 aa) |
| | blm | Uncharacterized protein. (1368 aa) |
| | A0A1L8GSW6 | Uncharacterized protein. (2175 aa) |
| | ccnb2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (392 aa) |
| | psmc2 | AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa) |
| | A0A1L8GU05 | Uncharacterized protein. (291 aa) |
| | Ube2n.S | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1311 aa) |
| | A0A1L8GWA8 | Uncharacterized protein. (209 aa) |
| | rad50-2 | Zinc-hook domain-containing protein. (1312 aa) |
| | ube2n | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | Gtse1.L | GTSE1_N domain-containing protein. (724 aa) |
| | mcm10 | Mcm10 domain-containing protein. (860 aa) |
| | A0A1L8GZK5 | Uncharacterized protein. (348 aa) |
| | A0A1L8H0E0 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (390 aa) |
| | tp53bp1 | Uncharacterized protein. (2179 aa) |
| | A0A1L8H1D5 | Uncharacterized protein. (1367 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa) |
| | Tp53.L | P53 domain-containing protein. (137 aa) |
| | A0A1L8H4Q1 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa) |
| | A0A1L8H4R2 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa) |
| | Psmb2.S | Proteasome subunit beta. (199 aa) |
| | ywhag | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | tdrd3 | Uncharacterized protein. (742 aa) |
| | Cdk2.S | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | Rcbtb1.S | BTB domain-containing protein. (600 aa) |
| | A0A1L8HBA4 | Uncharacterized protein. (103 aa) |
| | rnf169 | Uncharacterized protein. (483 aa) |
| | Recql4.L | Uncharacterized protein. (1504 aa) |
| | A0A1L8HCZ9 | Uncharacterized protein. (307 aa) |
| | Rpa1.L | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa) |
| | A0A1L8HDP1 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (233 aa) |
| | A0A1L8HF97 | Uncharacterized protein. (489 aa) |
| | ywhag-2 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | Rfc2.L | AAA domain-containing protein. (359 aa) |
| | Tdrd3.L | Uncharacterized protein. (775 aa) |
| | Cdk2.L | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | Rcbtb1.L | BTB domain-containing protein. (600 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa) |
| | rnf169-2 | Uncharacterized protein. (496 aa) |
| | Nsd2.S | Uncharacterized protein. (1300 aa) |
| | A0A1L8HMW1 | Uncharacterized protein. (149 aa) |
| | Pias4.S | Uncharacterized protein. (543 aa) |
| | kxd1 | KxDL domain-containing protein. (195 aa) |
| | A0A1L8HPD7 | Uncharacterized protein. (341 aa) |
| | Psme1.S | Uncharacterized protein. (244 aa) |
| | A0A1L8HPK4 | Uncharacterized protein. (256 aa) |
| | psmb5 | Proteasome subunit beta. (257 aa) |
| | A0A1L8HQ91 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | Cdc45.S | Uncharacterized protein. (580 aa) |
| | ubc | Uncharacterized protein. (533 aa) |
| | Rfc5.S | AAA domain-containing protein. (335 aa) |
| | A0A1L8HRA7 | Uncharacterized protein. (177 aa) |
| | A0A1L8HRF5 | Uncharacterized protein. (426 aa) |
| | nsd2 | Uncharacterized protein. (1300 aa) |
| | A0A1L8HTB6 | Uncharacterized protein. (198 aa) |
| | A0A1L8HVY7 | Uncharacterized protein. (326 aa) |
| | Pias4.L | Uncharacterized protein. (544 aa) |
| | wrn | Uncharacterized protein. (1434 aa) |
| | Kxd1.L | KxDL domain-containing protein. (195 aa) |
| | babam1 | Uncharacterized protein. (328 aa) |
| | A0A1L8HYF4 | DUF1767 domain-containing protein. (512 aa) |
| | psmb11 | Proteasome subunit beta. (276 aa) |
| | psmb5-2 | Proteasome subunit beta. (257 aa) |
| | A0A1L8I081 | Uncharacterized protein. (96 aa) |
| | Chek2.L | Uncharacterized protein. (392 aa) |
| | cdc45 | Uncharacterized protein. (567 aa) |
| | rad9b | Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa) |
| | A0A1L8I1K3 | Uncharacterized protein. (275 aa) |
| | slf1 | ANK_REP_REGION domain-containing protein. (904 aa) |
| | Rad17.L | Uncharacterized protein. (674 aa) |
| | ccnb1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (390 aa) |
| | wdr41 | Uncharacterized protein. (460 aa) |
| | rad1 | Uncharacterized protein. (283 aa) |
| | A0A310TK05 | Uncharacterized protein. (188 aa) |
| | A0A310TM08 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A310TM74 | Uncharacterized protein. (104 aa) |
| | A0A310TML1 | CENP-T_C domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (43 aa) |
| | A0A310TNN0 | Uncharacterized protein. (183 aa) |
| | A0A310TNW1 | Prot_ATP_ID_OB domain-containing protein. (153 aa) |
| | A0A310U368 | Histone H2B; Belongs to the histone H2B family. (94 aa) |
| | Hist1h4d.L | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | A0A310U9I4 | Uncharacterized protein. (485 aa) |
| | psmc2-2 | XMSS1 protein; Belongs to the AAA ATPase family. (433 aa) |
| | Clspn.S | Claspin. (1286 aa) |
| | psmc3-a | 26S proteasome regulatory subunit 6A-A; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (423 aa) |
| | ywhae | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | psmb6 | Proteasome subunit beta. (233 aa) |
| | rfc3 | MGC115007 protein. (356 aa) |
| | psma1 | Proteasome subunit alpha type. (261 aa) |
| | Psmb3 | Proteasome subunit beta. (205 aa) |
| | psmb3 | Proteasome subunit beta. (205 aa) |
| | psmd10 | LOC495968 protein. (227 aa) |
| | rpa3 | LOC495401 protein. (121 aa) |
| | psmf1 | LOC495127 protein. (263 aa) |
| | psme3 | Psme3b protein. (254 aa) |
| | psme1 | LOC494646 protein. (244 aa) |
| | psmd7-2 | MGC84052 protein. (320 aa) |
| | psmb7-2 | Proteasome subunit beta. (277 aa) |
| | rpa3-2 | Rpa3-prov protein. (121 aa) |
| | psma6 | Proteasome subunit alpha type. (246 aa) |
| | ywhah | MGC84451 protein; Belongs to the 14-3-3 family. (247 aa) |
| | psmd9 | MGC84770 protein. (208 aa) |
| | psme2 | MGC84168 protein. (242 aa) |
| | rps27a | MGC81889 protein. (156 aa) |
| | psma5 | Proteasome subunit alpha type. (247 aa) |
| | psmb2 | Proteasome subunit beta. (199 aa) |
| | psmc5-2 | MGC80185 protein; Belongs to the AAA ATPase family. (415 aa) |
| | psme3-2 | Psme3 protein. (254 aa) |
| | ccnb2-2 | MGC68601 protein; Belongs to the cyclin family. (392 aa) |
| | rfc4 | Replication factor C p37 subunit. (363 aa) |
| | ubc-2 | Ubc-prov protein. (609 aa) |
| | psmb7.2 | Proteasome subunit beta. (279 aa) |
| | psma4 | Proteasome subunit alpha type. (261 aa) |
| | rfc5 | Rfc5-prov protein. (335 aa) |
| | psmc3 | Psmc3-b protein; Belongs to the AAA ATPase family. (423 aa) |
| | psmd14 | Psmd14-prov protein. (310 aa) |
| | ywhaq | Ywhaq-prov protein; Belongs to the 14-3-3 family. (246 aa) |
| | rcbtb2 | Chc1l-prov protein. (526 aa) |
| | psmd6 | P44s10-prov protein. (389 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa) |
| | psmd9-2 | MGC53232 protein. (213 aa) |
| | psma3 | Proteasome subunit alpha type. (255 aa) |
| | Hus1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | psmb8 | Proteasome subunit beta. (271 aa) |
| | H2B | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Ccnb1.S | Cyclin B4; Belongs to the cyclin family. (393 aa) |
| | ccnb3 | Ccnb3-a protein; Belongs to the cyclin family. (416 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (807 aa) |
| | mcm6.2 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | Xcdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa) |
| | Psmd3.S | PCI domain-containing protein. (498 aa) |
| | ywhab | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | psmd11 | PCI domain-containing protein. (422 aa) |
| | psmc5 | AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa) |
| | psma7 | Proteasome subunit alpha type. (247 aa) |
| | Psmd12.S | PCI domain-containing protein. (455 aa) |
| | A0A1L8ENU1 | Uncharacterized protein; Belongs to the histone H2B family. (98 aa) |
| | cdca7 | zf-4CXXC_R1 domain-containing protein. (431 aa) |
| | A0A1L8EPM6 | ANK_REP_REGION domain-containing protein. (400 aa) |
| | Orc2.S | Uncharacterized protein. (558 aa) |
| | pkmyt1 | Protein kinase domain-containing protein. (548 aa) |
| | psmd3 | PCI domain-containing protein. (547 aa) |
| | Cdc6.L | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa) |
| | ywhab-2 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | psmd11-2 | PCI domain-containing protein. (422 aa) |
| | psma7-2 | Proteasome subunit alpha type. (248 aa) |
| | A0A1L8ET52 | Piezo-type mechanosensitive ion channel component. (2492 aa) |
| | Brca1.L | Uncharacterized protein. (1582 aa) |
| | Psmd12.L | PCI domain-containing protein. (455 aa) |
| | Mcm6.2.L | DNA helicase; Belongs to the MCM family. (823 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa) |
| | A0A1L8EVW9 | Uncharacterized protein; Belongs to the histone H2B family. (98 aa) |
| | bard1 | Uncharacterized protein. (839 aa) |
| | rmi2 | Uncharacterized protein. (152 aa) |
| | Meiob.L | Uncharacterized protein. (470 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa) |
| | pkmyt1-2 | Protein kinase domain-containing protein. (548 aa) |
| | exd2 | 3'-5' exonuclease domain-containing protein. (639 aa) |
| | A0A1L8EZQ1 | Proteasome subunit alpha type. (236 aa) |
| | A0A1L8EZW5 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (352 aa) |
| | Psmc6.S | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | psmc1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | A0A1L8F2E2 | Uncharacterized protein. (308 aa) |
| | Psmd10.S | ANK_REP_REGION domain-containing protein. (270 aa) |
| | Exo1.S | Uncharacterized protein. (734 aa) |
| | A0A1L8F3K4 | Proteasome subunit beta. (279 aa) |
| | Psmb9.S | Proteasome subunit beta. (215 aa) |
| | Psmd8.S | PCI domain-containing protein. (271 aa) |
| | psmb4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (249 aa) |
| | A0A1L8F5A2 | VWFA domain-containing protein. (635 aa) |
| | psmd5 | Uncharacterized protein. (505 aa) |
| | psmb7 | Proteasome subunit beta. (277 aa) |
| | Ccnb3.L | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (420 aa) |
| | brcc3 | MPN domain-containing protein. (261 aa) |
| | cntd2 | Uncharacterized protein; Belongs to the cyclin family. (368 aa) |
| | Psmd8.L | PCI domain-containing protein. (271 aa) |
| | Psmc1.L | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | psmc6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | exd2-2 | 3'-5' exonuclease domain-containing protein. (642 aa) |
| | Psmb4.L | Proteasome subunit beta; Belongs to the peptidase T1B family. (249 aa) |
| | A0A1L8FDD6 | VWFA domain-containing protein. (377 aa) |
| | cdk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | Dna2.S | Uncharacterized protein. (1053 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa) |
| | A0A1L8FHS4 | Prot_ATP_ID_OB domain-containing protein. (59 aa) |
| | A0A1L8FHT5 | AAA domain-containing protein. (240 aa) |
| | A0A1L8FHT9 | Uncharacterized protein. (94 aa) |
| | Cdk1.L | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa) |
| | chek1-2 | Protein kinase domain-containing protein. (510 aa) |
| | A0A1L8FPV0 | Uncharacterized protein. (145 aa) |
| | A0A1L8FQ56 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A1L8FQA5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | psma2 | Proteasome subunit alpha type. (234 aa) |
| | A0A1L8FSN5 | Piezo_RRas_bdg domain-containing protein. (710 aa) |
| | A0A1L8FSP1 | Uncharacterized protein. (382 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (1985 aa) |
| | A0A1L8FSQ8 | Uncharacterized protein. (127 aa) |
| | A0A1L8FSR6 | Piezo_RRas_bdg domain-containing protein. (299 aa) |
| | A0A1L8FSS5 | Uncharacterized protein. (572 aa) |
| | rbbp8 | Uncharacterized protein. (846 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (858 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | Ywhaz.L | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | dbf4 | Uncharacterized protein. (661 aa) |
| | A0A1L8FW69 | Uncharacterized protein. (279 aa) |
| | topbp1 | Uncharacterized protein. (1573 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | A0A1L8FXP8 | Uncharacterized protein. (349 aa) |
| | ankrd12-2 | ANK_REP_REGION domain-containing protein. (1961 aa) |
| | A0A1L8FYH5 | Piezo-type mechanosensitive ion channel component. (2805 aa) |
| | Rbbp8.L | Uncharacterized protein. (856 aa) |
| | Mcm4.S | DNA helicase; Belongs to the MCM family. (863 aa) |
| | A0A1L8FYX8 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (137 aa) |
| | Orc5.L | AAA_16 domain-containing protein. (440 aa) |
| | Nbn.L | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa) |
| | Ywhaz.S | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | hist1h4a | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H2B-2 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa) |
| | orc3 | ORC_WH_C domain-containing protein. (709 aa) |
| | A0A1L8G3T0 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (922 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa) |
| | A0A1L8G5V1 | Ubiquitin-like domain-containing protein. (156 aa) |
| | psme4 | Uncharacterized protein. (1828 aa) |
| | A0A1L8G614 | MCM domain-containing protein; Belongs to the MCM family. (798 aa) |
| | A0A1L8G6R5 | Histone H2B; Belongs to the histone H2B family. (347 aa) |
| | A0A1L8G6S1 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa) |
| | Bre.L | Uncharacterized protein. (404 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa) |
| | A0A1L8G6Z0 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | A0A1L8G784 | Uncharacterized protein. (171 aa) |
| | A0A1L8G795 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A1L8G869 | Uncharacterized protein. (166 aa) |
| | mcm9 | MCM domain-containing protein; Belongs to the MCM family. (1143 aa) |
| | Atr.L | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa) |
| | rnf168-2 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa) |
| | A0A1L8GBH4 | Uncharacterized protein. (148 aa) |
| | A0A1L8GBH6 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | zmcm3 | DNA helicase; Belongs to the MCM family. (806 aa) |
| | Psmd13.S | PCI domain-containing protein. (364 aa) |
| | Wee1.S | Wee1-like protein kinase. (595 aa) |
| | Psma1.S | Proteasome subunit alpha type. (295 aa) |
| | ankrd11 | ANK_REP_REGION domain-containing protein. (2741 aa) |
| | psmd7 | MPN domain-containing protein. (320 aa) |
| | piezo1 | Piezo-type mechanosensitive ion channel component. (2474 aa) |
| | ccnb1.2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (735 aa) |
| | atrip | Uncharacterized protein. (801 aa) |
| | A0A1L8GHN7 | Uncharacterized protein. (175 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (885 aa) |
| | A0A1L8GI18 | Uncharacterized protein. (364 aa) |
| | Wee1.L | Wee1-like protein kinase. (618 aa) |
| | A0A1L8GKR7 | Uncharacterized protein. (120 aa) |
| | Orc6.L | Uncharacterized protein. (252 aa) |
| | A0A1L8GLZ6 | Proteasome subunit alpha type. (261 aa) |
| | Ccnb1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa) |
| | Orc1.L | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa) |
| | A0A1L8GMX9 | Protein kinase domain-containing protein. (509 aa) |
