(21 nodes) Gastrin-CREB signalling pathway via PKC and MAPK network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hras	Small G-protein H-Ras. (189 aa)
	grb2	Uncharacterized protein. (229 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	A0A1L8EX51	Uncharacterized protein. (327 aa)
	kras	Uncharacterized protein. (186 aa)
	sos1	Uncharacterized protein. (1325 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	hbegf	EGF-like domain-containing protein. (196 aa)
	csde1	Uncharacterized protein. (833 aa)
	A0A1L8H940	Uncharacterized protein. (137 aa)
	cckbr	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	nras	Uncharacterized protein. (189 aa)
	A0A1L8HE12	Uncharacterized protein. (122 aa)
	Csde1.L	Uncharacterized protein. (780 aa)
	cckbr-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	Mapk1.L	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	krasl	Uncharacterized protein. (187 aa)
	kras-2	Uncharacterized protein. (187 aa)
	creb1	Creb1-prov protein. (324 aa)
	kras-3	LOC397771 protein. (186 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H940	Mapk1.L	A0A1L8H940	A0A1L8I0W2	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
A0A1L8H940	grb2	A0A1L8H940	A0A1L8EMZ6	Uncharacterized protein.	Uncharacterized protein.	0.593
A0A1L8H940	grb2-2	A0A1L8H940	A0A1L8EUF2	Uncharacterized protein.	Uncharacterized protein.	0.593
A0A1L8H940	hbegf	A0A1L8H940	A0A1L8GVF5	Uncharacterized protein.	EGF-like domain-containing protein.	0.413
A0A1L8H940	mapk1	A0A1L8H940	A0A1L8HQD8	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
A0A1L8H940	sos1	A0A1L8H940	A0A1L8G1Z8	Uncharacterized protein.	Uncharacterized protein.	0.631
A0A1L8H940	sos1-2	A0A1L8H940	A0A1L8G7X8	Uncharacterized protein.	Uncharacterized protein.	0.631
A0A1L8HE12	Mapk1.L	A0A1L8HE12	A0A1L8I0W2	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
A0A1L8HE12	grb2	A0A1L8HE12	A0A1L8EMZ6	Uncharacterized protein.	Uncharacterized protein.	0.593
A0A1L8HE12	grb2-2	A0A1L8HE12	A0A1L8EUF2	Uncharacterized protein.	Uncharacterized protein.	0.593
A0A1L8HE12	hbegf	A0A1L8HE12	A0A1L8GVF5	Uncharacterized protein.	EGF-like domain-containing protein.	0.413
A0A1L8HE12	mapk1	A0A1L8HE12	A0A1L8HQD8	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
A0A1L8HE12	sos1	A0A1L8HE12	A0A1L8G1Z8	Uncharacterized protein.	Uncharacterized protein.	0.631
A0A1L8HE12	sos1-2	A0A1L8HE12	A0A1L8G7X8	Uncharacterized protein.	Uncharacterized protein.	0.631
Csde1.L	Mapk1.L	A0A1L8HE42	A0A1L8I0W2	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
Csde1.L	grb2	A0A1L8HE42	A0A1L8EMZ6	Uncharacterized protein.	Uncharacterized protein.	0.593
Csde1.L	grb2-2	A0A1L8HE42	A0A1L8EUF2	Uncharacterized protein.	Uncharacterized protein.	0.593
Csde1.L	hbegf	A0A1L8HE42	A0A1L8GVF5	Uncharacterized protein.	EGF-like domain-containing protein.	0.413
Csde1.L	mapk1	A0A1L8HE42	A0A1L8HQD8	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.453
Csde1.L	sos1	A0A1L8HE42	A0A1L8G1Z8	Uncharacterized protein.	Uncharacterized protein.	0.631