(62 nodes) Calnexin/calreticulin cycle network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ganab.L	Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (999 aa)
	A0A1L8GHI1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (582 aa)
	edem3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (912 aa)
	A0A1L8GG47	Calreticulin. (445 aa)
	A0A1L8GD86	Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (951 aa)
	A0A1L8GCH1	Uncharacterized protein. (209 aa)
	uggt1	Uncharacterized protein. (1528 aa)
	A0A1L8GA80	B box-type domain-containing protein. (339 aa)
	A0A1L8G5V1	Ubiquitin-like domain-containing protein. (156 aa)
	Trim54.S	Uncharacterized protein. (281 aa)
	A0A1L8G465	Uncharacterized protein. (392 aa)
	Rnf139.L	RING-type domain-containing protein. (668 aa)
	trim55	Uncharacterized protein. (535 aa)
	A0A1L8FXH2	Uncharacterized protein. (188 aa)
	A0A1L8FXG4	Uncharacterized protein. (145 aa)
	March6.L	RING-CH-type domain-containing protein. (909 aa)
	Pdia4.L	Protein disulfide-isomerase. (648 aa)
	A0A1L8FTA7	Ubiquitin-like domain-containing protein. (105 aa)
	A0A1L8FT89	Uncharacterized protein. (435 aa)
	A0A1L8FS18	RING-CH-type domain-containing protein. (287 aa)
	march8-2	RING-CH-type domain-containing protein. (560 aa)
	march8	RING-CH-type domain-containing protein. (561 aa)
	Man1b1.L	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
	A0A1L8EW11	RING-CH-type domain-containing protein. (735 aa)
	A0A1L8EVG0	RING-CH-type domain-containing protein. (388 aa)
	edem2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (564 aa)
	March10.L	RING-CH-type domain-containing protein. (699 aa)
	A0A1L8ENP8	RING-CH-type domain-containing protein. (385 aa)
	March7.S	RING-CH-type domain-containing protein. (732 aa)
	canx	Canx-prov protein. (611 aa)
	pdia3-2	Protein disulfide-isomerase. (502 aa)
	ubc-2	Ubc-prov protein. (609 aa)
	uba52	MGC80109 protein. (128 aa)
	rps27a	MGC81889 protein. (156 aa)
	rnf139	MGC82066 protein. (662 aa)
	x-kf-1a	X-kf-1a protein. (678 aa)
	A0A310U4Q2	Uncharacterized protein. (394 aa)
	A0A310TKV3	Uncharacterized protein. (102 aa)
	march3-2	RING-CH-type domain-containing protein. (252 aa)
	A0A1L8HX68	Ubiquitin-like domain-containing protein. (173 aa)
	Kxd1.L	KxDL domain-containing protein. (195 aa)
	A0A1L8HWR9	RING-CH-type domain-containing protein. (281 aa)
	A0A1L8HUN9	Uncharacterized protein. (622 aa)
	march3	RING-CH-type domain-containing protein. (252 aa)
	ubc	Uncharacterized protein. (533 aa)
	kxd1	KxDL domain-containing protein. (195 aa)
	march2	RING-CH-type domain-containing protein. (246 aa)
	Clgn.S	Uncharacterized protein. (596 aa)
	A0A1L8HLM0	RING-CH-type domain-containing protein. (269 aa)
	rnf103	RING-type domain-containing protein. (670 aa)
	trim13-2	Uncharacterized protein. (411 aa)
	A0A1L8HI63	RING-CH-type domain-containing protein. (332 aa)
	uggt2	Uncharacterized protein. (1518 aa)
	A0A1L8HCZ9	Uncharacterized protein. (307 aa)
	trim13	Uncharacterized protein. (410 aa)
	march9	RING-CH-type domain-containing protein. (333 aa)
	A0A1L8H931	Uncharacterized protein. (1369 aa)
	Calr	Calreticulin. (412 aa)
	pdia3	Protein disulfide-isomerase. (500 aa)
	Edem1.L	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (620 aa)
	Edem3.L	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (913 aa)
	calr3	Calreticulin. (437 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FS18	March10.L	A0A1L8FS18	A0A1L8ESG0	RING-CH-type domain-containing protein.	RING-CH-type domain-containing protein.	0.566
A0A1L8FT89	A0A1L8G5V1	A0A1L8FT89	A0A1L8G5V1	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.471
A0A1L8FT89	A0A1L8HCZ9	A0A1L8FT89	A0A1L8HCZ9	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A1L8FT89	rps27a	A0A1L8FT89	Q6GMC1	Uncharacterized protein.	MGC81889 protein.	0.471
A0A1L8FT89	ubc	A0A1L8FT89	A0A1L8HQK4	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A1L8FT89	ubc-2	A0A1L8FT89	Q7SY79	Uncharacterized protein.	Ubc-prov protein.	0.404
A0A1L8FTA7	A0A1L8G5V1	A0A1L8FTA7	A0A1L8G5V1	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.989
A0A1L8FTA7	A0A1L8HCZ9	A0A1L8FTA7	A0A1L8HCZ9	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.908
A0A1L8FTA7	Rnf139.L	A0A1L8FTA7	A0A1L8G030	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.512
A0A1L8FTA7	rnf103	A0A1L8FTA7	A0A1L8HKS9	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.564
A0A1L8FTA7	rnf139	A0A1L8FTA7	Q6DJL3	Ubiquitin-like domain-containing protein.	MGC82066 protein.	0.512
A0A1L8FTA7	rps27a	A0A1L8FTA7	Q6GMC1	Ubiquitin-like domain-containing protein.	MGC81889 protein.	0.989
A0A1L8FTA7	ubc	A0A1L8FTA7	A0A1L8HQK4	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.907
A0A1L8FTA7	ubc-2	A0A1L8FTA7	Q7SY79	Ubiquitin-like domain-containing protein.	Ubc-prov protein.	0.907
A0A1L8FTA7	x-kf-1a	A0A1L8FTA7	Q08AX3	Ubiquitin-like domain-containing protein.	X-kf-1a protein.	0.564
A0A1L8FXH2	March10.L	A0A1L8FXH2	A0A1L8ESG0	Uncharacterized protein.	RING-CH-type domain-containing protein.	0.566
A0A1L8G465	A0A1L8G5V1	A0A1L8G465	A0A1L8G5V1	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.471
A0A1L8G465	A0A1L8HCZ9	A0A1L8G465	A0A1L8HCZ9	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A1L8G465	rps27a	A0A1L8G465	Q6GMC1	Uncharacterized protein.	MGC81889 protein.	0.471
A0A1L8G465	ubc	A0A1L8G465	A0A1L8HQK4	Uncharacterized protein.	Uncharacterized protein.	0.404