(186 nodes) CDC42 GTPase cycle network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	arhgap32	Uncharacterized protein. (1989 aa)
	A0A1L8HJQ0	Uncharacterized protein. (374 aa)
	A0A1L8HKH7	Uncharacterized protein. (169 aa)
	A0A1L8HKZ9	Uncharacterized protein. (1559 aa)
	A0A1L8HL98	Uncharacterized protein. (1090 aa)
	Arhgap10.S	Uncharacterized protein. (784 aa)
	Arhgap45.S	Uncharacterized protein. (991 aa)
	cdc42se2l	CRIB domain-containing protein. (84 aa)
	bcr	Uncharacterized protein. (1160 aa)
	A0A1L8HTT9	Uncharacterized protein. (490 aa)
	A0A1L8HU33	Uncharacterized protein. (1090 aa)
	Arhgap24.L	Rho-GAP domain-containing protein. (499 aa)
	A0A1L8HVN3	PH domain-containing protein. (346 aa)
	arhgap45	Uncharacterized protein. (1107 aa)
	Myo9b.L	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2143 aa)
	dock8	Uncharacterized protein; Belongs to the DOCK family. (2056 aa)
	cdc42se2l-2	CRIB domain-containing protein. (84 aa)
	Bcr.L	Uncharacterized protein. (1180 aa)
	depdc1b	Rho-GAP domain-containing protein. (529 aa)
	A0A310U1N4	Uncharacterized protein. (416 aa)
	Arhgap40.L	Rho-GAP domain-containing protein. (633 aa)
	A0A310UA75	Uncharacterized protein; Belongs to the DOCK family. (1991 aa)
	A0A310UBN1	Uncharacterized protein. (530 aa)
	A0A310UBS6	Uncharacterized protein. (940 aa)
	arhgap36	LOC100158279 protein. (532 aa)
	itsn1	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for cdc42, and thereby stimulates actin nucleation mediated by wasl and the arp2/3 complex (By similarity). Involved in endocytosis of activated egfr, and probably also other growth factor receptors (By similarity). (1705 aa)
	arhgap10	MGC130928 protein. (789 aa)
	gna13-2	Heterotrimeric guanine nucleotide binding protein subunit alpha-13. (377 aa)
	arhgdib	LOC496152 protein. (200 aa)
	arhgdia	Arhgdia protein. (204 aa)
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	arhgdig	MGC69119 protein. (199 aa)
	arhgdib-2	Arhgdib-prov protein. (200 aa)
	Cav-3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	lbr	Lamin B receptor. (620 aa)
	Wipf2.S	WH2 domain-containing protein. (448 aa)
	A0A1L8ELH8	Uncharacterized protein. (1485 aa)
	arhgap40	Rho-GAP domain-containing protein. (637 aa)
	A0A1L8EMN2	Uncharacterized protein. (1019 aa)
	A0A1L8EN56	Uncharacterized protein. (930 aa)
	arhgap17	Uncharacterized protein. (822 aa)
	Wipf2.L	WH2 domain-containing protein. (427 aa)
	A0A1L8ESR0	Uncharacterized protein. (87 aa)
	A0A1L8EU28	Uncharacterized protein. (1019 aa)
	A0A1L8EUS4	Uncharacterized protein. (931 aa)
	gna13	Uncharacterized protein. (377 aa)
	Racgap1.2.L	Uncharacterized protein. (608 aa)
	arhgap17-2	Uncharacterized protein. (858 aa)
	A0A1L8EZS8	Rib_recp_KP_reg domain-containing protein. (175 aa)
	A0A1L8EZW3	Uncharacterized protein. (777 aa)
	fgd1	Uncharacterized protein. (867 aa)
	Arhgap4.S	Uncharacterized protein. (960 aa)
	A0A1L8F273	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	A0A1L8F2K3	Uncharacterized protein. (438 aa)
	A0A1L8F2L6	Uncharacterized protein. (213 aa)
	A0A1L8F3B4	Uncharacterized protein. (1076 aa)
	arhgap35	Uncharacterized protein. (1476 aa)
	A0A1L8F443	Uncharacterized protein. (2003 aa)
	arhgap5	Uncharacterized protein. (1498 aa)
	A0A1L8F475	Uncharacterized protein. (1350 aa)
	Arhgap30.S	Rho-GAP domain-containing protein. (1403 aa)
	A0A1L8F6T4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	arhgap4	Uncharacterized protein. (988 aa)
	A0A1L8F6U2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	A0A1L8F784	Uncharacterized protein. (1352 aa)
	Dock11.L	Uncharacterized protein; Belongs to the DOCK family. (2072 aa)
	A0A1L8F824	Uncharacterized protein. (1116 aa)
	arhgap35-2	Uncharacterized protein. (1480 aa)
	shkbp1	BTB domain-containing protein. (816 aa)
	A0A1L8F951	Uncharacterized protein. (613 aa)
	A0A1L8F9T7	Uncharacterized protein. (447 aa)
	A0A1L8FAD2	Uncharacterized protein. (1361 aa)
	fmn1	FH2 domain-containing protein. (1393 aa)
	A0A1L8FAW9	Uncharacterized protein. (1447 aa)
	arhgap5-2	Uncharacterized protein. (1495 aa)
	arhgap30	Rho-GAP domain-containing protein. (1343 aa)
	A0A1L8FDP4	Uncharacterized protein. (1758 aa)
	dnmbp	Uncharacterized protein. (1548 aa)
	A0A1L8FGA0	Uncharacterized protein. (191 aa)
	arhgef16	Uncharacterized protein. (708 aa)
	A0A1L8FHG0	Uncharacterized protein. (581 aa)
	Arhgef19.L	Uncharacterized protein. (570 aa)
	Arhgap33.S	Uncharacterized protein. (1105 aa)
	A0A1L8FI35	DH domain-containing protein. (1852 aa)
	dnmbp-2	Uncharacterized protein. (1552 aa)
	arhgap22	Uncharacterized protein. (547 aa)
	Arhgap32.L	Uncharacterized protein. (1940 aa)
	arhgef16-2	Uncharacterized protein. (714 aa)
	Arhgap33.L	Uncharacterized protein. (1149 aa)
	Arhgap21.S	Uncharacterized protein. (1925 aa)
	Ralbp1-a	Rho-GAP domain-containing protein. (655 aa)
	A0A1L8FU62	Uncharacterized protein. (899 aa)
	Arhgap21.L	Uncharacterized protein. (1786 aa)
	ralbp1	Rho-GAP domain-containing protein. (646 aa)
	A0A1L8FZ77	Uncharacterized protein. (1564 aa)
	A0A1L8G0J6	Uncharacterized protein. (541 aa)
	A0A1L8G155	BTB domain-containing protein. (785 aa)
	rrbp1	Rib_recp_KP_reg domain-containing protein. (1047 aa)
	plekhg1	Uncharacterized protein. (1545 aa)
	arhgef10	DH domain-containing protein. (1383 aa)
	A0A1L8G3U6	Uncharacterized protein. (1234 aa)
	Ect2.S	Uncharacterized protein. (987 aa)
	arhgef26	Uncharacterized protein. (868 aa)
	Dock10.S	Uncharacterized protein; Belongs to the DOCK family. (2159 aa)
	ngef	Uncharacterized protein. (691 aa)
	arhgef4	Uncharacterized protein. (658 aa)
	Kctd3.L	Uncharacterized protein. (229 aa)
	A0A1L8G6A1	Uncharacterized protein. (182 aa)
	A0A1L8G6H5	Uncharacterized protein. (106 aa)
	A0A1L8G6J4	Uncharacterized protein. (60 aa)
	Lbr.L	S5A_REDUCTASE domain-containing protein. (592 aa)
	A0A1L8G6T3	Uncharacterized protein. (95 aa)
	Rrbp1.L	Rib_recp_KP_reg domain-containing protein. (1055 aa)
	plekhg1-2	Uncharacterized protein. (1510 aa)
	fmn2	FH2 domain-containing protein. (1611 aa)
	Tagap.L	Rho-GAP domain-containing protein. (905 aa)
	arhgef10-2	DH domain-containing protein. (1379 aa)
	A0A1L8G9U4	Uncharacterized protein. (1231 aa)
	A0A1L8GAE1	Uncharacterized protein; Belongs to the DOCK family. (2181 aa)
	ect2	Uncharacterized protein. (986 aa)
	ngef-2	Uncharacterized protein. (691 aa)
	arhgef4-2	Uncharacterized protein. (619 aa)
	arhgef26-2	Uncharacterized protein. (868 aa)
	Arhgap1.S	Uncharacterized protein. (473 aa)
	plekhg4	Uncharacterized protein. (1918 aa)
	A0A1L8GFG4	Uncharacterized protein; Belongs to the DOCK family. (2018 aa)
	arhgap29	Uncharacterized protein. (1341 aa)
	A0A1L8GHN5	Uncharacterized protein. (1074 aa)
	Arhgap1.L	Uncharacterized protein. (435 aa)
	plekhg4-2	Uncharacterized protein. (1902 aa)
	A0A1L8GM43	Uncharacterized protein; Belongs to the DOCK family. (2098 aa)
	arhgap29-2	Uncharacterized protein. (1352 aa)
	A0A1L8GPB5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	A0A1L8GPL2	Uncharacterized protein. (1087 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	Fgd4.S	Uncharacterized protein. (758 aa)
	ykt6	Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
	cdc42se2	CRIB domain-containing protein. (75 aa)
	A0A1L8GUK2	Uncharacterized protein. (1073 aa)
	arhgap26	Uncharacterized protein. (759 aa)
	fam13b	Rho-GAP domain-containing protein. (830 aa)
	A0A1L8GVL2	Uncharacterized protein. (1751 aa)
	A0A1L8GW82	Uncharacterized protein. (646 aa)
	Fgd4.L	Uncharacterized protein. (822 aa)
	A0A1L8GX86	Uncharacterized protein. (1803 aa)
	fam13b-2	Rho-GAP domain-containing protein. (835 aa)
	arhgap26-2	Uncharacterized protein. (759 aa)
	A0A1L8GYI0	Uncharacterized protein. (1073 aa)
	cdc42se2-2	CRIB domain-containing protein. (75 aa)
	ykt6-2	Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
	Gmip.L	Uncharacterized protein. (860 aa)
	A0A1L8H465	Uncharacterized protein. (1172 aa)
	Abr.S	Uncharacterized protein. (991 aa)
	Itsn1.S	Uncharacterized protein. (1670 aa)
	arhgap31	Rho-GAP domain-containing protein. (1404 aa)
	A0A1L8H762	Uncharacterized protein. (1025 aa)
	A0A1L8H8W3	Uncharacterized protein. (1214 aa)
	A0A1L8H923	Uncharacterized protein; Belongs to the DOCK family. (2086 aa)
	A0A1L8H926	Uncharacterized protein. (1329 aa)
	arhgef25	Uncharacterized protein. (753 aa)
	Racgap1.S	Uncharacterized protein. (629 aa)
	stard13	Uncharacterized protein. (1118 aa)
	A0A1L8HAQ1	Uncharacterized protein. (1135 aa)
	A0A1L8HAX9	Uncharacterized protein. (873 aa)
	arhgap20	Uncharacterized protein. (1184 aa)
	A0A1L8HBH1	Uncharacterized protein. (1627 aa)
	A0A1L8HBX0	Uncharacterized protein. (428 aa)
	Arhgap31.L	Rho-GAP domain-containing protein. (1249 aa)
	Itsn1.L	Uncharacterized protein. (1270 aa)
	abr	Uncharacterized protein. (1018 aa)
	wdr81	Uncharacterized protein. (1871 aa)
	Srgap2.L	Uncharacterized protein. (1022 aa)
	A0A1L8HH24	Uncharacterized protein. (1439 aa)
	A0A1L8HH66	DUF3398 domain-containing protein. (39 aa)
	A0A1L8HH72	Uncharacterized protein. (1290 aa)
	A0A1L8HH91	Uncharacterized protein. (41 aa)
	A0A1L8HH94	Uncharacterized protein. (69 aa)
	A0A1L8HHE5	Uncharacterized protein; Belongs to the DOCK family. (2008 aa)
	arhgef25-2	Uncharacterized protein. (751 aa)
	Racgap1.L	Uncharacterized protein. (629 aa)
	stard13-2	Uncharacterized protein. (1118 aa)
	A0A1L8HIV9	Uncharacterized protein. (289 aa)
	A0A1L8HJ33	Uncharacterized protein. (1255 aa)
	arhgap20-2	Uncharacterized protein. (1182 aa)
	A0A1L8HJE8	Uncharacterized protein. (874 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELH8	A0A1L8FGA0	A0A1L8ELH8	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.854
A0A1L8ELH8	Itsn1.L	A0A1L8ELH8	A0A1L8HCL0	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A1L8ELH8	Itsn1.S	A0A1L8ELH8	A0A1L8H582	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A1L8ELH8	itsn1	A0A1L8ELH8	O42287	Uncharacterized protein.	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for cdc42, and thereby stimulates actin nucleation mediated by wasl and the arp2/3 complex (By similarity). Involved in endocytosis of activated egfr, and probably also other growth factor receptors (By similarity).	0.506
A0A1L8EMN2	A0A1L8FGA0	A0A1L8EMN2	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.508
A0A1L8EMN2	Arhgap1.L	A0A1L8EMN2	A0A1L8GIS6	Uncharacterized protein.	Uncharacterized protein.	0.431
A0A1L8EMN2	Arhgap1.S	A0A1L8EMN2	A0A1L8GE02	Uncharacterized protein.	Uncharacterized protein.	0.431
A0A1L8EN56	A0A1L8FGA0	A0A1L8EN56	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.588
A0A1L8ESR0	A0A1L8FGA0	A0A1L8ESR0	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.854
A0A1L8ESR0	Itsn1.L	A0A1L8ESR0	A0A1L8HCL0	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A1L8ESR0	Itsn1.S	A0A1L8ESR0	A0A1L8H582	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A1L8ESR0	itsn1	A0A1L8ESR0	O42287	Uncharacterized protein.	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for cdc42, and thereby stimulates actin nucleation mediated by wasl and the arp2/3 complex (By similarity). Involved in endocytosis of activated egfr, and probably also other growth factor receptors (By similarity).	0.506
A0A1L8EU28	A0A1L8FGA0	A0A1L8EU28	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.508
A0A1L8EU28	Arhgap1.L	A0A1L8EU28	A0A1L8GIS6	Uncharacterized protein.	Uncharacterized protein.	0.431
A0A1L8EU28	Arhgap1.S	A0A1L8EU28	A0A1L8GE02	Uncharacterized protein.	Uncharacterized protein.	0.431
A0A1L8EUS4	A0A1L8FGA0	A0A1L8EUS4	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.588
A0A1L8EZS8	A0A1L8FGA0	A0A1L8EZS8	A0A1L8FGA0	Rib_recp_KP_reg domain-containing protein.	Uncharacterized protein.	0.578
A0A1L8EZW3	A0A1L8FGA0	A0A1L8EZW3	A0A1L8FGA0	Uncharacterized protein.	Uncharacterized protein.	0.612
A0A1L8EZW3	lbr	A0A1L8EZW3	Q9W708	Uncharacterized protein.	Lamin B receptor.	0.429
A0A1L8F273	A0A1L8F6T4	A0A1L8F273	A0A1L8F6T4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.419