(47 nodes) Thioredoxin network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tmx2.S	Thioredoxin domain-containing protein. (203 aa)
	txndc12-2	Tlp19-prov protein. (168 aa)
	pdia3-2	Protein disulfide-isomerase. (502 aa)
	pdia6	Pdip5-prov protein; Belongs to the protein disulfide isomerase family. (442 aa)
	nxnl2	MGC83491 protein. (156 aa)
	txnl1	MGC81675 protein. (289 aa)
	p4hb	Protein disulfide-isomerase. (506 aa)
	tmx1-2	LOC100158326 protein. (264 aa)
	txndc12	Thioredoxin domain-containing protein. (168 aa)
	LOC100037235	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	Txnl1.L	PITH domain-containing protein. (289 aa)
	A0A1L8HY24	Thioredoxin domain-containing protein. (108 aa)
	A0A1L8HXS7	Uncharacterized protein. (82 aa)
	tusc3	Uncharacterized protein. (346 aa)
	A0A1L8HNW1	Thioredoxin domain-containing protein. (151 aa)
	txndc9	Thioredoxin domain-containing protein. (226 aa)
	nxn-2	Thioredoxin domain-containing protein. (414 aa)
	pdia3	Protein disulfide-isomerase. (500 aa)
	txndc15	Thioredoxin domain-containing protein. (342 aa)
	Qsox1.L	Sulfhydryl oxidase. (718 aa)
	A0A1L8GG57	Sulfhydryl oxidase. (695 aa)
	Pdia6.L	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (442 aa)
	Tmx4.L	Thioredoxin domain-containing protein. (372 aa)
	Txndc5.L	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (403 aa)
	Pdia4.L	Protein disulfide-isomerase. (648 aa)
	Erp44.L	Thioredoxin domain-containing protein. (407 aa)
	Tmx3.S	Thioredoxin domain-containing protein. (452 aa)
	txndc5	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (404 aa)
	dnajc16-2	Uncharacterized protein. (777 aa)
	glrx3	Uncharacterized protein. (326 aa)
	dnajc16	Uncharacterized protein. (777 aa)
	Glrx3.S	Uncharacterized protein. (326 aa)
	txndc16	Thioredoxin domain-containing protein. (809 aa)
	Magt1.L	Uncharacterized protein. (329 aa)
	A0A1L8F2H4	Uncharacterized protein. (400 aa)
	Qsox2.S	Sulfhydryl oxidase. (659 aa)
	tmx1	Thioredoxin domain-containing protein. (264 aa)
	Pdia2.L	Protein disulfide-isomerase. (526 aa)
	pdilt	Thioredoxin domain-containing protein. (542 aa)
	txndc11	Uncharacterized protein. (891 aa)
	Nme9.L	Uncharacterized protein; Belongs to the NDK family. (625 aa)
	Dnajc10.S	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (796 aa)
	Pdilt.S	Thioredoxin domain-containing protein. (523 aa)
	pdia2	Protein disulfide-isomerase. (526 aa)
	Pdia5.L	Uncharacterized protein. (523 aa)
	dnajc10	Uncharacterized protein. (797 aa)
	Pdia5.S	Uncharacterized protein. (524 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HNW1	Erp44.L	A0A1L8HNW1	A0A1L8FX09	Thioredoxin domain-containing protein.	Thioredoxin domain-containing protein.	0.421
A0A1L8HNW1	Txndc5.L	A0A1L8HNW1	A0A1L8FXX3	Thioredoxin domain-containing protein.	Uncharacterized protein; Belongs to the protein disulfide isomerase family.	0.400
Dnajc10.S	Erp44.L	A0A1L8EPM5	A0A1L8FX09	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Thioredoxin domain-containing protein.	0.425
Dnajc10.S	Nme9.L	A0A1L8EPM5	A0A1L8EWQ5	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Uncharacterized protein; Belongs to the NDK family.	0.742
Dnajc10.S	Pdia2.L	A0A1L8EPM5	A0A1L8EYS9	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	Pdia4.L	A0A1L8EPM5	A0A1L8FX18	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	dnajc10	A0A1L8EPM5	A0A1L8EWF7	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Uncharacterized protein.	0.504
Dnajc10.S	dnajc16	A0A1L8EPM5	A0A1L8FHP4	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Uncharacterized protein.	0.411
Dnajc10.S	dnajc16-2	A0A1L8EPM5	A0A1L8FPF2	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Uncharacterized protein.	0.411
Dnajc10.S	p4hb	A0A1L8EPM5	Q6DD55	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	pdia2	A0A1L8EPM5	A0A1L8ER13	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	pdia3	A0A1L8EPM5	A0A1L8H0R6	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	pdia3-2	A0A1L8EPM5	Q7ZWU3	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.490
Dnajc10.S	txndc11	A0A1L8EPM5	A0A1L8EXL4	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Uncharacterized protein.	0.523
Erp44.L	A0A1L8HNW1	A0A1L8FX09	A0A1L8HNW1	Thioredoxin domain-containing protein.	Thioredoxin domain-containing protein.	0.421
Erp44.L	Dnajc10.S	A0A1L8FX09	A0A1L8EPM5	Thioredoxin domain-containing protein.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.425
Erp44.L	LOC100037235	A0A1L8FX09	A2VDE6	Thioredoxin domain-containing protein.	Thioredoxin; Belongs to the thioredoxin family.	0.411
Erp44.L	Tmx3.S	A0A1L8FX09	A0A1L8FSL5	Thioredoxin domain-containing protein.	Thioredoxin domain-containing protein.	0.420
Erp44.L	Tmx4.L	A0A1L8FX09	A0A1L8G617	Thioredoxin domain-containing protein.	Thioredoxin domain-containing protein.	0.611
Erp44.L	dnajc10	A0A1L8FX09	A0A1L8EWF7	Thioredoxin domain-containing protein.	Uncharacterized protein.	0.425