14 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	Rfc2.L	AAA domain-containing protein. (359 aa)
	rfc1	Replication factor C subunit 1. (1147 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	cdc25c	Tyrosine phosphatase. (550 aa)
	rfc4	Replication factor C p37 subunit. (363 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atr.L	Cdk2.S	A0A1L8GAP7	A0A1L8H9N1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
Atr.L	Chek2.L	A0A1L8GAP7	A0A1L8I0A0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Hus1	A0A1L8GAP7	Q8JHD8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Checkpoint protein; Belongs to the HUS1 family.	0.999
Atr.L	Pold1.L	A0A1L8GAP7	A0A1L8FNR6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA polymerase.	0.625
Atr.L	Rad17.L	A0A1L8GAP7	A0A1L8I1Y0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.991
Atr.L	Rfc2.L	A0A1L8GAP7	A0A1L8HGA4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	AAA domain-containing protein.	0.948
Atr.L	cdc25c	A0A1L8GAP7	B7ZP67	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Tyrosine phosphatase.	0.740
Atr.L	chek1	A0A1L8GAP7	A0A1L8FFS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Atr.L	chek1-2	A0A1L8GAP7	A0A1L8FL95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.999
Atr.L	pcna	A0A1L8GAP7	Q9I893	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.743
Atr.L	rad9a	A0A1L8GAP7	Q7ZZU5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.998
Atr.L	rfc1	A0A1L8GAP7	A0A1L8HTJ6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Replication factor C subunit 1.	0.437
Atr.L	rfc4	A0A1L8GAP7	Q76LD2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Replication factor C p37 subunit.	0.957
Cdk2.S	Atr.L	A0A1L8H9N1	A0A1L8GAP7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
Cdk2.S	Chek2.L	A0A1L8H9N1	A0A1L8I0A0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.574
Cdk2.S	Hus1	A0A1L8H9N1	Q8JHD8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Checkpoint protein; Belongs to the HUS1 family.	0.606
Cdk2.S	Pold1.L	A0A1L8H9N1	A0A1L8FNR6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA polymerase.	0.551
Cdk2.S	Rad17.L	A0A1L8H9N1	A0A1L8I1Y0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.476
Cdk2.S	cdc25c	A0A1L8H9N1	B7ZP67	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Tyrosine phosphatase.	0.992
Cdk2.S	chek1	A0A1L8H9N1	A0A1L8FFS1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.731