29 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	Recql4.L	Uncharacterized protein. (1504 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	Rfc2.L	AAA domain-containing protein. (359 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Orc2.S	Uncharacterized protein. (558 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Endog.L	Endonuclease. (290 aa)
	dntt	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (507 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	A0A1L8FPM5	Uncharacterized protein. (363 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	mlh1	DNA mismatch repair protein MutL-homolog 1. (750 aa)
	Clspn.S	Claspin. (1286 aa)
	rfc4	Replication factor C p37 subunit. (363 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	Wee1.S	Wee1-like protein kinase. (595 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	fen1-2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	blm	Uncharacterized protein. (1368 aa)
	Wee2	Wee1-like protein kinase. (534 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FPM5	Atr.L	A0A1L8FPM5	A0A1L8GAP7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.810
A0A1L8FPM5	Brca1.L	A0A1L8FPM5	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.576
A0A1L8FPM5	Chek2.L	A0A1L8FPM5	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A1L8FPM5	Clspn.S	A0A1L8FPM5	F8WKR8	Uncharacterized protein.	Claspin.	0.405
A0A1L8FPM5	Endog.L	A0A1L8FPM5	A0A1L8F798	Uncharacterized protein.	Endonuclease.	0.585
A0A1L8FPM5	Hus1	A0A1L8FPM5	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.897
A0A1L8FPM5	Nbn.L	A0A1L8FPM5	A0A1L8FZE8	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.898
A0A1L8FPM5	Pold1.L	A0A1L8FPM5	A0A1L8FNR6	Uncharacterized protein.	DNA polymerase.	0.993
A0A1L8FPM5	Rad17.L	A0A1L8FPM5	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.771
A0A1L8FPM5	Recql4.L	A0A1L8FPM5	A0A1L8HBS7	Uncharacterized protein.	Uncharacterized protein.	0.941
A0A1L8FPM5	Rfc2.L	A0A1L8FPM5	A0A1L8HGA4	Uncharacterized protein.	AAA domain-containing protein.	0.925
A0A1L8FPM5	Rpa1.L	A0A1L8FPM5	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
A0A1L8FPM5	blm	A0A1L8FPM5	A0A1L8GSC3	Uncharacterized protein.	Uncharacterized protein.	0.932
A0A1L8FPM5	chek1-2	A0A1L8FPM5	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.660
A0A1L8FPM5	dntt	A0A1L8FPM5	A0A1L8FJ83	Uncharacterized protein.	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	0.674
A0A1L8FPM5	fen1	A0A1L8FPM5	A0A1L8GDJ8	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.906
A0A1L8FPM5	fen1-2	A0A1L8FPM5	A0A1L8GJ67	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.906
A0A1L8FPM5	mlh1	A0A1L8FPM5	A0AUU1	Uncharacterized protein.	DNA mismatch repair protein MutL-homolog 1.	0.892
A0A1L8FPM5	msh2	A0A1L8FPM5	A0A1L8G6D6	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.930
A0A1L8FPM5	rad50	A0A1L8FPM5	A0A1L8GVF0	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.870