66 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	siah1-2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	creb1	Creb1-prov protein. (324 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	A0A1L8H5Z7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (534 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	ctbp1	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	rab40b	MGC85390 protein. (278 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	cox1	Cyclooxygenase 1. (587 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	Cyct.L	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	cyct	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	rxra	Uncharacterized protein. (488 aa)
	ctbp2	Uncharacterized protein. (973 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	Casp9.S	Uncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	A0A1L8FJ10	Uncharacterized protein. (987 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	cycs	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	A0A1L8FW52	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	igf2	IlGF domain-containing protein. (217 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	ep300	Uncharacterized protein. (2495 aa)
	Ptgs2.S	EGF-like domain-containing protein. (726 aa)
	Mst1.S	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (716 aa)
	igf2-2	IlGF domain-containing protein. (217 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	mst1	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
	Rho.L	Rhodopsin. (459 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	ctbp2l	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (480 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	LOC494997	LOC494997 protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
	rac1	MGC114731 protein. (192 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	ctbp2l-2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
	wif1	Uncharacterized protein. (374 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FJ10	Hdac3.S	A0A1L8FJ10	A0A1L8GVJ7	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.500
A0A1L8FJ10	crebbp	A0A1L8FJ10	A0A1L8EQR2	Uncharacterized protein.	Uncharacterized protein.	0.512
A0A1L8FJ10	crebbp-2	A0A1L8FJ10	A0A1L8EYE5	Uncharacterized protein.	Uncharacterized protein.	0.512
A0A1L8FJ10	ctnnb1	A0A1L8FJ10	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.753
A0A1L8FJ10	ep300	A0A1L8FJ10	A0A1L8GGW2	Uncharacterized protein.	Uncharacterized protein.	0.509
A0A1L8FJ10	ep300-2	A0A1L8FJ10	A0A1L8GNI9	Uncharacterized protein.	Uncharacterized protein.	0.509
A0A1L8FW52	Casp9.S	A0A1L8FW52	A0A1L8FHM1	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.999
A0A1L8FW52	Tp53.L	A0A1L8FW52	A0A1L8H4M6	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	P53 domain-containing protein.	0.826
A0A1L8FW52	ccnd1	A0A1L8FW52	Q8AVQ4	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Ccnd1-prov protein; Belongs to the cyclin family.	0.402
A0A1L8FW52	myc	A0A1L8FW52	Q6NRN4	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.456
A0A1L8H5Q6	Axin1.S	A0A1L8H5Q6	A0A1L8ER48	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.999
A0A1L8H5Q6	Cdh3.S	A0A1L8H5Q6	A0A1L8GET9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.588
A0A1L8H5Q6	Egf.L	A0A1L8H5Q6	A0A1L8HUT3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.509
A0A1L8H5Q6	Lrp5.L	A0A1L8H5Q6	A0A1L8GJX4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.896
A0A1L8H5Q6	Myc.S	A0A1L8H5Q6	A0A1L8FTW7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Myc_N domain-containing protein.	0.626
A0A1L8H5Q6	Tp53.L	A0A1L8H5Q6	A0A1L8H4M6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	P53 domain-containing protein.	0.594
A0A1L8H5Q6	Wnt1.L	A0A1L8H5Q6	A0A1L8HHR8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
A0A1L8H5Q6	bmp4	A0A1L8H5Q6	B7ZPR8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Bone morphogenetic protein 4.	0.429
A0A1L8H5Q6	bmp4-2	A0A1L8H5Q6	Q91703	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Bone morphogenetic protein 4.	0.439
A0A1L8H5Q6	ccnd1	A0A1L8H5Q6	Q8AVQ4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Ccnd1-prov protein; Belongs to the cyclin family.	0.978