10 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	kremen2	Uncharacterized protein. (420 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kremen1.S	Lrp5.L	A0A1L8HQW5	A0A1L8GJX4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Uncharacterized protein.	0.971
Kremen1.S	ctnnb1	A0A1L8HQW5	Q63ZT4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Beta-catenin protein.	0.579
Kremen1.S	dkk1	A0A1L8HQW5	A0A1L8FIS6	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.997
Kremen1.S	dkk1-2	A0A1L8HQW5	O57464	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf homolog 1.	0.998
Kremen1.S	dkk2	A0A1L8HQW5	A0A1L8HM80	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.979
Kremen1.S	dkk2-2	A0A1L8HQW5	Q9DDA4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf homolog 2.	0.979
Kremen2.S	Lrp5.L	A0A1L8ER80	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.939
Kremen2.S	ctnnb1	A0A1L8ER80	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.511
Kremen2.S	dkk1	A0A1L8ER80	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.953
Kremen2.S	dkk1-2	A0A1L8ER80	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.953
Kremen2.S	dkk2	A0A1L8ER80	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.874
Kremen2.S	dkk2-2	A0A1L8ER80	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.873
Lrp5.L	Kremen1.S	A0A1L8GJX4	A0A1L8HQW5	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971
Lrp5.L	Kremen2.S	A0A1L8GJX4	A0A1L8ER80	Uncharacterized protein.	Uncharacterized protein.	0.939
Lrp5.L	ctnnb1	A0A1L8GJX4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.974
Lrp5.L	dkk1	A0A1L8GJX4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.999
Lrp5.L	dkk1-2	A0A1L8GJX4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.999
Lrp5.L	dkk2	A0A1L8GJX4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.999
Lrp5.L	dkk2-2	A0A1L8GJX4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.999
Lrp5.L	kremen1	A0A1L8GJX4	A0A1L8I1A4	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971