41 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Myog.S	BHLH domain-containing protein. (236 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	kremen2	Uncharacterized protein. (420 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	C1r.L	Uncharacterized protein; Belongs to the peptidase S1 family. (496 aa)
	C1s.L	Uncharacterized protein; Belongs to the peptidase S1 family. (687 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	axin2	Uncharacterized protein. (707 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	A0A1L8G2F6	Uncharacterized protein. (566 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	bmp1	Metalloendopeptidase. (976 aa)
	plat	Plasminogen activator; Belongs to the peptidase S1 family. (566 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	rspo1	Uncharacterized protein. (257 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	Bmp1	Metalloendopeptidase. (977 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (607 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	myog	Myogenin U1. (235 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	Dkk3.S	A0A1L8ENI4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Sfrp1.L	A0A1L8ENI4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	dkk2	A0A1L8ENI4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.665
A0A1L8ENI4	dkk2-2	A0A1L8ENI4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.666
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922
A0A1L8ENI4	lef1-2	A0A1L8ENI4	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.922
A0A1L8ENI4	ror2	A0A1L8ENI4	A0A1L8HPI6	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.604
A0A1L8ENI4	ror2-2	A0A1L8ENI4	Q8AV69	Uncharacterized protein.	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.604
A0A1L8ENI4	sfrp1	A0A1L8ENI4	A0A1L8GRT5	Uncharacterized protein.	Uncharacterized protein.	0.720
A0A1L8ENI4	wnt1	A0A1L8ENI4	A0A1L8H9S8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	wnt3a	A0A1L8ENI4	A0A1L8FUX8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.929
A0A1L8ENI4	wnt4	A0A1L8ENI4	A0A1L8FG99	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.756
A0A1L8ENI4	wnt4-2	A0A1L8ENI4	A0A1L8FM93	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.756