STRINGSTRING
A0A1L8FQ56 A0A1L8FQ56 Upf1.S Upf1.S plk4 plk4 Cdk2.S Cdk2.S Snip1.S Snip1.S Tp53.L Tp53.L tipin tipin upf2 upf2 mcm10 mcm10 rad50-2 rad50-2 rad50 rad50 Tipin.S Tipin.S fancd2 fancd2 Rad26 Rad26 plk3-2 plk3-2 mcm2 mcm2 atrip atrip Atr.L Atr.L A0A1L8G795 A0A1L8G795 A0A1L8G6S1 A0A1L8G6S1 A0A1L8G6R5 A0A1L8G6R5 H2B-2 H2B-2 Prkdc.L Prkdc.L topbp1 topbp1 A0A1L8FQA5 A0A1L8FQA5 chek1-2 chek1-2 chek1 chek1 mdc1 mdc1 mlst8 mlst8 plk1 plk1 Trrap.L Trrap.L Smg1.L Smg1.L Brca1.L Brca1.L A0A1L8ENU1 A0A1L8ENU1 smg1 smg1 trrap trrap Plk1.S Plk1.S Cdc6.L Cdc6.L pcna pcna H2B H2B plk2 plk2 Hus1 Hus1 rad9a rad9a upf2-2 upf2-2 Clspn.S Clspn.S PIK3R1 PIK3R1 A0A310U368 A0A310U368 A0A310TM08 A0A310TM08 Rad17.L Rad17.L cdc45 cdc45 Chek2.L Chek2.L Xpa.L Xpa.L A0A1L8HWF9 A0A1L8HWF9 wrn wrn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1L8FQ56Histone H2B; Belongs to the histone H2B family. (126 aa)
Upf1.SUncharacterized protein. (1098 aa)
plk4Serine/threonine-protein kinase PLK. (983 aa)
Cdk2.SProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
Snip1.SFHA domain-containing protein. (367 aa)
Tp53.LP53 domain-containing protein. (137 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
upf2Uncharacterized protein. (1265 aa)
mcm10Mcm10 domain-containing protein. (860 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
Tipin.STIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
fancd2Uncharacterized protein. (1445 aa)
Rad26Uncharacterized protein. (798 aa)
plk3-2Serine/threonine-protein kinase PLK. (663 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
atripUncharacterized protein. (801 aa)
Atr.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
A0A1L8G795Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A1L8G6S1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa)
A0A1L8G6R5Histone H2B; Belongs to the histone H2B family. (347 aa)
H2B-2Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
Prkdc.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
topbp1Uncharacterized protein. (1573 aa)
A0A1L8FQA5Histone H2B; Belongs to the histone H2B family. (126 aa)
chek1-2Protein kinase domain-containing protein. (510 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
mdc1Uncharacterized protein. (2103 aa)
mlst8WD_REPEATS_REGION domain-containing protein. (327 aa)
plk1Serine/threonine-protein kinase PLK. (598 aa)
Trrap.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3828 aa)
Smg1.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3654 aa)
Brca1.LUncharacterized protein. (1582 aa)
A0A1L8ENU1Uncharacterized protein; Belongs to the histone H2B family. (98 aa)
smg1Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3654 aa)
trrapUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3838 aa)
Plk1.SSerine/threonine-protein kinase PLK. (598 aa)
Cdc6.LCell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
H2BHistone H2B; Belongs to the histone H2B family. (126 aa)
plk2Serine/threonine-protein kinase PLK. (666 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
upf2-2MGC115246 protein. (1264 aa)
Clspn.SClaspin. (1286 aa)
PIK3R1Phosphoinositide-3-kinase. (722 aa)
A0A310U368Histone H2B; Belongs to the histone H2B family. (94 aa)
A0A310TM08Histone H2B; Belongs to the histone H2B family. (126 aa)
Rad17.LUncharacterized protein. (674 aa)
cdc45Uncharacterized protein. (567 aa)
Chek2.LUncharacterized protein. (392 aa)
Xpa.LXPA_C domain-containing protein. (265 aa)
A0A1L8HWF9Serine/threonine-protein kinase PLK. (608 aa)
wrnUncharacterized protein. (1434 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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