18 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	mcm10	Mcm10 domain-containing protein. (860 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	Rad26	Uncharacterized protein. (798 aa)
	mcm5-2	DNA helicase; Belongs to the MCM family. (735 aa)
	atrip	Uncharacterized protein. (801 aa)
	mcm5	DNA helicase; Belongs to the MCM family. (735 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Wdhd1.L	Uncharacterized protein. (1127 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GS29	Brca1.L	A0A1L8GS29	A0A1L8ETS4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.480
A0A1L8GS29	Rad17.L	A0A1L8GS29	A0A1L8I1Y0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.904
A0A1L8GS29	Wdhd1.L	A0A1L8GS29	A0A1L8F9Z9	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.753
A0A1L8GS29	chek1	A0A1L8GS29	A0A1L8FFS1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.635
A0A1L8GS29	chek1-2	A0A1L8GS29	A0A1L8FL95	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein.	0.635
A0A1L8GS29	mcm10	A0A1L8GS29	A0A1L8GZD7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Mcm10 domain-containing protein.	0.718
A0A1L8GS29	mcm5	A0A1L8GS29	A0A1L8GGS4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.875
A0A1L8GS29	mcm5-2	A0A1L8GS29	A0A1L8GNF3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.875
Brca1.L	A0A1L8GS29	A0A1L8ETS4	A0A1L8GS29	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.480
Brca1.L	Hus1	A0A1L8ETS4	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.885
Brca1.L	Rad17.L	A0A1L8ETS4	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.877
Brca1.L	Rad26	A0A1L8ETS4	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.959
Brca1.L	Wdhd1.L	A0A1L8ETS4	A0A1L8F9Z9	Uncharacterized protein.	Uncharacterized protein.	0.709
Brca1.L	atrip	A0A1L8ETS4	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.959
Brca1.L	chek1	A0A1L8ETS4	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.980
Brca1.L	chek1-2	A0A1L8ETS4	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.980
Brca1.L	mcm10	A0A1L8ETS4	A0A1L8GZD7	Uncharacterized protein.	Mcm10 domain-containing protein.	0.596
Brca1.L	myc	A0A1L8ETS4	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.749
Brca1.L	pcna	A0A1L8ETS4	Q9I893	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.528
Brca1.L	rad9a	A0A1L8ETS4	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.905