(61 nodes) (2009) Transcriptional regulation of mammalian selenoprotein expression. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cebpd	CCAAT/enhancer-binding protein. (281 aa)
	Cebpb.S	CCAAT/enhancer-binding protein. (288 aa)
	gli2	Uncharacterized protein. (1468 aa)
	srebf1	BHLH domain-containing protein. (1159 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Cebpb.L	CCAAT/enhancer-binding protein. (281 aa)
	gli2-2	Uncharacterized protein. (1475 aa)
	foxo4	Fork-head domain-containing protein. (492 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	gata1	Uncharacterized protein. (367 aa)
	arnt	Uncharacterized protein. (762 aa)
	Foxo4.L	Fork-head domain-containing protein. (485 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Arnt.L	Uncharacterized protein. (765 aa)
	Selenon.S	EF-hand domain-containing protein. (539 aa)
	Cebpd.S	CCAAT/enhancer-binding protein. (283 aa)
	Selenon.L	EF-hand domain-containing protein. (542 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	foxo3	Fork-head domain-containing protein. (656 aa)
	Selenot.S	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (184 aa)
	gata4	Uncharacterized protein. (392 aa)
	Foxa2.L	Fork-head domain-containing protein. (434 aa)
	Foxo3.L	Fork-head domain-containing protein. (661 aa)
	Selenot.L	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (185 aa)
	Nfat5.S	RHD domain-containing protein. (1348 aa)
	Trh.S	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (224 aa)
	Nfat5.L	RHD domain-containing protein. (1369 aa)
	Trh.L	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (227 aa)
	nkx3-1	Homeobox domain-containing protein. (213 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Selenos.S	Uncharacterized protein. (186 aa)
	A0A1L8GUI6	Uncharacterized protein. (183 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
	ifng	Uncharacterized protein. (182 aa)
	Selenoo.L	Uncharacterized protein. (681 aa)
	Selenos.L	Uncharacterized protein. (191 aa)
	Il1b.L	Interleukin-1. (145 aa)
	Nkx3-1.L	Homeobox domain-containing protein. (213 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	tshb	Cys_knot domain-containing protein. (141 aa)
	foxo1	Fork-head domain-containing protein. (626 aa)
	tshb-2	Cys_knot domain-containing protein. (141 aa)
	foxo1-2	Fork-head domain-containing protein. (631 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	LOC100037235	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	fos	BZIP domain-containing protein. (369 aa)
	gata1a-A	GATA binding factor-1. (359 aa)
	il1b-A	Interleukin-1; Belongs to the IL-1 family. (283 aa)
	src	Tyrosine-protein kinase. (532 aa)
	tbp	LOC503680 protein. (296 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	fos-2	MGC80305 protein. (368 aa)
	MGC80314	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	gata4-2	MGC81427 protein. (394 aa)
	stat5b	Signal transducer and activator of transcription. (781 aa)
	prdx6	MGC64582 protein. (224 aa)
	prdx6-2	Prdx6-prov protein. (224 aa)
	nkx2-5-2	Nkx2.5 protein. (299 aa)
	creb1	Creb1-prov protein. (324 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	cebpa	CCAAT/enhancer-binding protein. (305 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GUI6	Egf.L	A0A1L8GUI6	A0A1L8HUT3	Uncharacterized protein.	Uncharacterized protein.	0.615
A0A1L8GUI6	Il1b.L	A0A1L8GUI6	A0A1L8H1M6	Uncharacterized protein.	Interleukin-1.	0.835
A0A1L8GUI6	Tp53.L	A0A1L8GUI6	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.546
A0A1L8GUI6	ctnnb1	A0A1L8GUI6	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.448
A0A1L8GUI6	fos	A0A1L8GUI6	A9UMM6	Uncharacterized protein.	BZIP domain-containing protein.	0.415
A0A1L8GUI6	fos-2	A0A1L8GUI6	Q6AXA4	Uncharacterized protein.	MGC80305 protein.	0.415
A0A1L8GUI6	ifng	A0A1L8GUI6	A0A1L8GYI9	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8GUI6	il1b-A	A0A1L8GUI6	B7ZSG9	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.835
A0A1L8GUI6	src	A0A1L8GUI6	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.446
A0A1L8GUI6	stat3.1	A0A1L8GUI6	A0A1L8ERT1	Uncharacterized protein.	Signal transducer and activator of transcription.	0.769
A0A1L8GUI6	stat5b	A0A1L8GUI6	Q6NU32	Uncharacterized protein.	Signal transducer and activator of transcription.	0.658
A0A1L8GUI6	tgfb1	A0A1L8GUI6	A0A1L8F3Y7	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.638
A0A1L8GUI6	tgfb1-2	A0A1L8GUI6	A0A1L8F936	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.638
Cebpb.L	Cebpd.S	A0A1L8ESS1	A0A1L8FT13	CCAAT/enhancer-binding protein.	CCAAT/enhancer-binding protein.	0.741
Cebpb.L	Il1b.L	A0A1L8ESS1	A0A1L8H1M6	CCAAT/enhancer-binding protein.	Interleukin-1.	0.431
Cebpb.L	Smad3	A0A1L8ESS1	A0A1L8GSA7	CCAAT/enhancer-binding protein.	Mothers against decapentaplegic homolog.	0.466
Cebpb.L	Tp53.L	A0A1L8ESS1	A0A1L8H4M6	CCAAT/enhancer-binding protein.	P53 domain-containing protein.	0.536
Cebpb.L	cebpa	A0A1L8ESS1	Q91346	CCAAT/enhancer-binding protein.	CCAAT/enhancer-binding protein.	0.595
Cebpb.L	cebpd	A0A1L8ESS1	Q76E40	CCAAT/enhancer-binding protein.	CCAAT/enhancer-binding protein.	0.741
Cebpb.L	creb1	A0A1L8ESS1	Q8AVY5	CCAAT/enhancer-binding protein.	Creb1-prov protein.	0.716