(28 nodes) (2010) Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hdac1-2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	A0A310U4X8	Glyceraldehyde-3-phosphate dehydrogenase. (294 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	cyp26b1-2	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	cyp26b1	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	hdac7-2	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	Ncor1.L	Uncharacterized protein. (2518 aa)
	hdac7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
	Ybx2.L	CSD_1 domain-containing protein. (342 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	rars	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (660 aa)
	dmc1	Uncharacterized protein; Belongs to the RecA family. (341 aa)
	sycp3	Cor1 domain-containing protein. (237 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	A0A1L8G8Y0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	A0A1L8G2V6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
	cables1-2	Cyclin N-terminal domain-containing protein. (563 aa)
	cables1	Cyclin N-terminal domain-containing protein. (549 aa)
	Hdac6.L	Hist_deacetyl domain-containing protein. (564 aa)
	abl1	Tyrosine-protein kinase. (1122 aa)
	Hdac4.L	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
	Hdac5.S	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G2V6	Hdac4.L	A0A1L8G2V6	A0A1L8EWI7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.540
A0A1L8G2V6	Hdac5.S	A0A1L8G2V6	A0A1L8EL25	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.552
A0A1L8G2V6	Hdac6.L	A0A1L8G2V6	A0A1L8F5I4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Hist_deacetyl domain-containing protein.	0.563
A0A1L8G2V6	Ncor1.L	A0A1L8G2V6	A0A1L8HD08	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.758
A0A1L8G2V6	hdac4	A0A1L8G2V6	A0A1L8EPF2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.539
A0A1L8G2V6	hdac5	A0A1L8G2V6	A0A1L8ES84	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.552
A0A1L8G2V6	hdac7	A0A1L8G2V6	A0A1L8H9Z7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.558
A0A1L8G2V6	hdac7-2	A0A1L8G2V6	A0A1L8HID5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.558
A0A1L8G8Y0	Hdac4.L	A0A1L8G8Y0	A0A1L8EWI7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.538
A0A1L8G8Y0	Hdac5.S	A0A1L8G8Y0	A0A1L8EL25	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.550
A0A1L8G8Y0	Hdac6.L	A0A1L8G8Y0	A0A1L8F5I4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Hist_deacetyl domain-containing protein.	0.559
A0A1L8G8Y0	Ncor1.L	A0A1L8G8Y0	A0A1L8HD08	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.825
A0A1L8G8Y0	hdac1	A0A1L8G8Y0	A0A1L8HFI8	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.900
A0A1L8G8Y0	hdac1-2	A0A1L8G8Y0	Q7ZYT5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.900
A0A1L8G8Y0	hdac4	A0A1L8G8Y0	A0A1L8EPF2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.537
A0A1L8G8Y0	hdac5	A0A1L8G8Y0	A0A1L8ES84	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.551
A0A1L8G8Y0	hdac7	A0A1L8G8Y0	A0A1L8H9Z7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.557
A0A1L8G8Y0	hdac7-2	A0A1L8G8Y0	A0A1L8HID5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.557
A0A310U4X8	Gapdh.S	A0A310U4X8	Q7ZY52	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.901
A0A310U4X8	dmc1	A0A310U4X8	A0A1L8GNT7	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein; Belongs to the RecA family.	0.481