90 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sema3a-2	Uncharacterized protein; Belongs to the semaphorin family. (774 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	bmp7.1	TGF_BETA_2 domain-containing protein. (424 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	wnt9b.2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	bcl9l	BCL9 domain-containing protein. (1281 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	axin2	Uncharacterized protein. (707 aa)
	A0A1L8FQM4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	A0A1L8G525	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (704 aa)
	sdc1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (607 aa)
	lrp4	Uncharacterized protein. (1906 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	ep300	Uncharacterized protein. (2495 aa)
	lrp4-2	Uncharacterized protein. (1908 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	ruvbl1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	sema3a	Uncharacterized protein; Belongs to the semaphorin family. (771 aa)
	msx2	Homeobox domain-containing protein. (257 aa)
	msx2-2	Homeobox domain-containing protein. (257 aa)
	wif1	Uncharacterized protein. (374 aa)
	Bmp7.2.L	TGF_BETA_2 domain-containing protein. (438 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	bcl9	BCL9 domain-containing protein. (1473 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	A0A1L8H5Z7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (534 aa)
	nck2	Cytoplasmic protein. (381 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Bcl9.L	BCL9 domain-containing protein. (1387 aa)
	cdkn1a	Uncharacterized protein. (261 aa)
	nck2-2	Cytoplasmic protein. (381 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	A0A1L8HJF4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (456 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	msx1	Homeobox domain-containing protein. (275 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	fst	Uncharacterized protein. (339 aa)
	Pitx2.S	Homeobox protein. (326 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	fst-2	Uncharacterized protein. (341 aa)
	msx1-2	LOC100125666 protein. (273 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	rspo2	R-spondin 2. (243 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	grem1	Gremlin. (182 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
	sox9-a	Sex determining region Y-box 9. (477 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	nck1	Cytoplasmic protein. (377 aa)
	hmga2	LOC100158391 protein. (105 aa)
	nck1-2	Cytoplasmic protein. (377 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	hmga2-2	MGC81571 protein. (105 aa)
	pitx2	Homeobox protein. (323 aa)
	ruvbl1-2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	klf9	Basic transcription element binding protein 1. (292 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	ptch1-2	Patched-1. (1418 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	bmp7.1-2	Osteogenic protein-1 homolog. (424 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	A0A1L8H5Z7	A0A1L8ENI4	A0A1L8H5Z7	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.504
A0A1L8ENI4	A0A1L8HJF4	A0A1L8ENI4	A0A1L8HJF4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.457
A0A1L8ENI4	Bcl9.L	A0A1L8ENI4	A0A1L8HC43	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	Dkk3.S	A0A1L8ENI4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Sfrp1.L	A0A1L8ENI4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1L8ENI4	Shh.L	A0A1L8ENI4	A0A1L8FV87	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.668
A0A1L8ENI4	Sox2.S	A0A1L8ENI4	A0A1L8EK54	Uncharacterized protein.	HMG box domain-containing protein.	0.445
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	bcl9	A0A1L8ENI4	A0A1L8H5D8	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	bmp4	A0A1L8ENI4	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.569
A0A1L8ENI4	bmp4-2	A0A1L8ENI4	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.561
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	dkk2	A0A1L8ENI4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.665
A0A1L8ENI4	dkk2-2	A0A1L8ENI4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.666
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922