(25 nodes) (2011) Direct interaction between NHERF1 and Frizzled regulates beta-catenin signaling. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	pth1r	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (539 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	Tjp1.S	Uncharacterized protein; Belongs to the MAGUK family. (1705 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Alb.S	Uncharacterized protein. (607 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	LOC733155	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (318 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	slc9a3r1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (316 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	sdcbp	MGC81274 protein. (295 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb.S	Esr1.S	A0A1L8HMG9	A0A1L8G265	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.555
Alb.S	Gapdh.S	A0A1L8HMG9	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
Alb.S	Tjp1.S	A0A1L8HMG9	A0A1L8H090	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.474
Alb.S	ctnnb1	A0A1L8HMG9	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.633
Alb.S	esr1	A0A1L8HMG9	Q6W5G7	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.555
Alb.S	gapdh	A0A1L8HMG9	Q8AY70	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
Alb.S	myc	A0A1L8HMG9	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.676
Alb.S	wnt3a	A0A1L8HMG9	A0A1L8FUX8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.429
Esr1.S	Alb.S	A0A1L8G265	A0A1L8HMG9	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.555
Esr1.S	Gapdh.S	A0A1L8G265	Q7ZY52	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Glyceraldehyde-3-phosphate dehydrogenase.	0.515
Esr1.S	LOC100189571	A0A1L8G265	B7ZRX0	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.613
Esr1.S	ccnd1	A0A1L8G265	Q8AVQ4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Ccnd1-prov protein; Belongs to the cyclin family.	0.892
Esr1.S	ctnnb1	A0A1L8G265	Q63ZT4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Beta-catenin protein.	0.759
Esr1.S	gapdh	A0A1L8G265	Q8AY70	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Glyceraldehyde-3-phosphate dehydrogenase.	0.515
Esr1.S	myc	A0A1L8G265	Q6NRN4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.652
Esr1.S	pten	A0A1L8G265	A1L2J3	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.597
Fzd4.S	Fzd6.S	A0A1L8HB90	A0A1L8FTP5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.586
Fzd4.S	ccnd1	A0A1L8HB90	Q8AVQ4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Ccnd1-prov protein; Belongs to the cyclin family.	0.409
Fzd4.S	ctnnb1	A0A1L8HB90	Q63ZT4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Beta-catenin protein.	0.871
Fzd4.S	fz3	A0A1L8HB90	B7ZQS8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.587