(45 nodes) (2011) A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling. network (Xenopus laevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rbpj	Uncharacterized protein. (487 aa)
	not	Homeobox domain-containing protein. (233 aa)
	ptch2-2	Patched-2. (1413 aa)
	pcdh1	Uncharacterized protein. (1237 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	enc1.2	MGC53471 protein. (588 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	ptch2	SSD domain-containing protein. (1422 aa)
	tbxt-2	MGC81453 protein. (432 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	foxd4l1.1	Winged helix protein. (352 aa)
	foxd4l1.2	Forkhead domain transcription factor. (342 aa)
	Hes4.L	Orange domain-containing protein. (171 aa)
	gli2	Uncharacterized protein. (1468 aa)
	gli2-2	Uncharacterized protein. (1475 aa)
	foxa1	Fork-head domain-containing protein. (427 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	foxa1-2	Fork-head domain-containing protein. (429 aa)
	hes4	Uncharacterized protein. (277 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	hey1-2	Uncharacterized protein. (298 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
	tbxt	Uncharacterized protein. (432 aa)
	Chrd.1.S	Chordin; Belongs to the chordin family. (941 aa)
	nkx2-2-2	Homeobox domain-containing protein. (271 aa)
	Foxa2.L	Fork-head domain-containing protein. (434 aa)
	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (445 aa)
	A0A1L8GA23	Chordin; Belongs to the chordin family. (940 aa)
	A0A1L8GA54	Uncharacterized protein. (882 aa)
	Foxa4.S	Fork-head domain-containing protein. (400 aa)
	mdk	Uncharacterized protein. (142 aa)
	spon1	Uncharacterized protein. (803 aa)
	Mdk.L	Uncharacterized protein. (173 aa)
	foxa4	Fork-head domain-containing protein. (399 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	AXPC	Uncharacterized protein. (1204 aa)
	Rbpj.S	Uncharacterized protein. (485 aa)
	Gli1.L	Uncharacterized protein. (1362 aa)
	gli1	Uncharacterized protein. (1361 aa)
	ptch1-2	Patched-1. (1418 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZY9	A0A1L8G7M0	A0A1L8EZY9	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8EZY9	Notch1.S	A0A1L8EZY9	A0A1L8F124	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.960
A0A1L8EZY9	Rbpj.S	A0A1L8EZY9	A0A1L8HL49	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.460
A0A1L8EZY9	dll1	A0A1L8EZY9	A0A1L8G230	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.400
A0A1L8EZY9	dll1-2	A0A1L8EZY9	Q91902	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.400
A0A1L8EZY9	notch1	A0A1L8EZY9	A0A1L8F627	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.960
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900
A0A1L8EZY9	psen2	A0A1L8EZY9	A0A1L8G245	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8EZY9	rbpj	A0A1L8EZY9	A0A1L8HTS9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.460
A0A1L8G7M0	A0A1L8EZY9	A0A1L8G7M0	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8G7M0	Notch1.S	A0A1L8G7M0	A0A1L8F124	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.911
A0A1L8G7M0	Rbpj.S	A0A1L8G7M0	A0A1L8HL49	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.458
A0A1L8G7M0	notch1	A0A1L8G7M0	A0A1L8F627	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.911
A0A1L8G7M0	psen1	A0A1L8G7M0	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8G7M0	rbpj	A0A1L8G7M0	A0A1L8HTS9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.458
A0A1L8GA23	A0A1L8GA54	A0A1L8GA23	A0A1L8GA54	Chordin; Belongs to the chordin family.	Uncharacterized protein.	0.900
A0A1L8GA23	Chrd.1.S	A0A1L8GA23	A0A1L8G404	Chordin; Belongs to the chordin family.	Chordin; Belongs to the chordin family.	0.900
A0A1L8GA23	Foxa2.L	A0A1L8GA23	A0A1L8G794	Chordin; Belongs to the chordin family.	Fork-head domain-containing protein.	0.580
A0A1L8GA23	Foxa4.S	A0A1L8GA23	A0A1L8GCR0	Chordin; Belongs to the chordin family.	Fork-head domain-containing protein.	0.580
A0A1L8GA23	Notch1.S	A0A1L8GA23	A0A1L8F124	Chordin; Belongs to the chordin family.	Uncharacterized protein.	0.480