49 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gli3-2	Uncharacterized protein. (1568 aa)
	A0A1L8ELB6	Uncharacterized protein. (261 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	gli2	Uncharacterized protein. (1468 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	gli2-2	Uncharacterized protein. (1475 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	Smarca1.L	Uncharacterized protein. (1034 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	axin2	Uncharacterized protein. (707 aa)
	gli3	Uncharacterized protein. (1565 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	tnik	Uncharacterized protein. (1326 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	ep300	Uncharacterized protein. (2495 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	wif1	Uncharacterized protein. (374 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	bcl9	BCL9 domain-containing protein. (1473 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	gli1	Uncharacterized protein. (1361 aa)
	Bcl9.L	BCL9 domain-containing protein. (1387 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Gli1.L	Uncharacterized protein. (1362 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	csnk1g2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	Xporc-d	Xporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	ptch1-2	Patched-1. (1418 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	csnk1e	Casein kinase I epsilon; Belongs to the protein kinase superfamily. (416 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELB6	A0A1L8H5Q6	A0A1L8ELB6	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.460
A0A1L8ELB6	Shh.L	A0A1L8ELB6	A0A1L8FV87	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.428
A0A1L8ELB6	ctnnb1	A0A1L8ELB6	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.509
A0A1L8ELB6	myc	A0A1L8ELB6	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.449
A0A1L8ENI4	A0A1L8GQT6	A0A1L8ENI4	A0A1L8GQT6	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.849
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	Bcl9.L	A0A1L8ENI4	A0A1L8HC43	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Gli1.L	A0A1L8ENI4	A0A1L8HI29	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1L8ENI4	Jag1.L	A0A1L8ENI4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Shh.L	A0A1L8ENI4	A0A1L8FV87	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.668
A0A1L8ENI4	Smo.L	A0A1L8ENI4	A0A1L8GZN4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.464
A0A1L8ENI4	Smo.S	A0A1L8ENI4	A0A1L8GTP2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.464
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Xporc-d	A0A1L8ENI4	Q6DFF3	Uncharacterized protein.	Xporc-d protein; Belongs to the membrane-bound acyltransferase family.	0.460
A0A1L8ENI4	bcl9	A0A1L8ENI4	A0A1L8H5D8	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	csnk1e	A0A1L8ENI4	Q9PUI2	Uncharacterized protein.	Casein kinase I epsilon; Belongs to the protein kinase superfamily.	0.966
A0A1L8ENI4	csnk1g2	A0A1L8ENI4	A0A1L8HWS0	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.556
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998