23 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	mbp	Uncharacterized protein. (308 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	atrip	Uncharacterized protein. (801 aa)
	faap24	Uncharacterized protein. (216 aa)
	Rad26	Uncharacterized protein. (798 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	A0A1L8H9R2	Uncharacterized protein. (1288 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	Xpa.L	XPA_C domain-containing protein. (265 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	cdc45	Uncharacterized protein. (567 aa)
	mbp-2	Golli protein J37.1. (306 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	Clspn.S	Claspin. (1286 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H9R2	Chek2.L	A0A1L8H9R2	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.779
A0A1L8H9R2	Clspn.S	A0A1L8H9R2	F8WKR8	Uncharacterized protein.	Claspin.	0.997
A0A1L8H9R2	Hus1	A0A1L8H9R2	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.834
A0A1L8H9R2	Mrc1.L	A0A1L8H9R2	A0A1L8H4B7	Uncharacterized protein.	C-type lectin domain-containing protein.	0.933
A0A1L8H9R2	Rad26	A0A1L8H9R2	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	Rpa1.L	A0A1L8H9R2	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.929
A0A1L8H9R2	Tipin.S	A0A1L8H9R2	A0A1L8GSF3	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.999
A0A1L8H9R2	atrip	A0A1L8H9R2	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	cdc45	A0A1L8H9R2	A0A1L8I0M4	Uncharacterized protein.	Uncharacterized protein.	0.990
A0A1L8H9R2	chek1	A0A1L8H9R2	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.933
A0A1L8H9R2	chek1-2	A0A1L8H9R2	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.925
A0A1L8H9R2	rad9a	A0A1L8H9R2	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.806
A0A1L8H9R2	tipin	A0A1L8H9R2	A0A1L8H168	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.999
A0A1L8H9R2	topbp1	A0A1L8H9R2	A0A1L8FWJ6	Uncharacterized protein.	Uncharacterized protein.	0.929
Cdc25a.S	Chek2.L	A0A1L8FQA3	A0A1L8I0A0	Rhodanese domain-containing protein.	Uncharacterized protein.	0.995
Cdc25a.S	Clspn.S	A0A1L8FQA3	F8WKR8	Rhodanese domain-containing protein.	Claspin.	0.756
Cdc25a.S	Hus1	A0A1L8FQA3	Q8JHD8	Rhodanese domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.523
Cdc25a.S	Rad26	A0A1L8FQA3	A0A1L8GP12	Rhodanese domain-containing protein.	Uncharacterized protein.	0.742
Cdc25a.S	atrip	A0A1L8FQA3	A0A1L8GH95	Rhodanese domain-containing protein.	Uncharacterized protein.	0.742
Cdc25a.S	cdc45	A0A1L8FQA3	A0A1L8I0M4	Rhodanese domain-containing protein.	Uncharacterized protein.	0.647