61 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mapk10	Mitogen-activated protein kinase. (426 aa)
	Ipmk.L	Kinase; Belongs to the inositol phosphokinase (IPK) family. (402 aa)
	irak4	Protein kinase domain-containing protein. (458 aa)
	ntf3-2	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (274 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (274 aa)
	brpf1-2	Uncharacterized protein. (1251 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1259 aa)
	brpf1	Uncharacterized protein. (1251 aa)
	bdnf	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
	Hivep2.L	Uncharacterized protein. (2426 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	srf-2	MADS-box domain-containing protein. (448 aa)
	A0A1L8G5V8	Uncharacterized protein. (205 aa)
	sos1	Uncharacterized protein. (1325 aa)
	atf3	BZIP domain-containing protein. (182 aa)
	A0A1L8G1C6	Uncharacterized protein. (205 aa)
	srf	MADS-box domain-containing protein. (449 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	Znf250.L	Uncharacterized protein. (499 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	zbtb17	Uncharacterized protein. (708 aa)
	A0A1L8FNJ3	NGF domain-containing protein; Belongs to the NGF-beta family. (236 aa)
	A0A1L8EKE1	NGF domain-containing protein; Belongs to the NGF-beta family. (202 aa)
	ppp1r1b	Uncharacterized protein. (183 aa)
	Hnf4a.S	Uncharacterized protein. (466 aa)
	mafb	BZIP domain-containing protein. (313 aa)
	A0A1L8ENI2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	mafb-2	BZIP domain-containing protein. (310 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1280 aa)
	rgs11	Uncharacterized protein. (683 aa)
	A0A1L8EVB6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	Nr2f5.S	Uncharacterized protein. (398 aa)
	shc1	Uncharacterized protein. (605 aa)
	Hprt1.L	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (289 aa)
	rps6ka5	Ribosomal protein S6 kinase. (782 aa)
	Shc1.L	Uncharacterized protein. (601 aa)
	ipmk	Kinase; Belongs to the inositol phosphokinase (IPK) family. (401 aa)
	rps6ka3	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (737 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	klf8	AP-2 repressor. (357 aa)
	rps6ka1	Ribosomal protein S6 kinase. (733 aa)
	pik3r1	MGC80357 protein. (722 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	rapgef1	MGC80732 protein. (1035 aa)
	gng7-2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	atf3-2	MGC81814 protein. (181 aa)
	bdnf-2	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	Plcg1.S	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	fst-2	Uncharacterized protein. (341 aa)
	wdr41	Uncharacterized protein. (460 aa)
	mapk10-2	Mitogen-activated protein kinase. (444 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	fst	Uncharacterized protein. (339 aa)
	gng7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	Gtf3a.L	Uncharacterized protein. (366 aa)
	Map2k7.S	Protein kinase domain-containing protein. (489 aa)
	map2k1-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKE1	Plcg1.S	A0A1L8EKE1	A0A310TNX3	NGF domain-containing protein; Belongs to the NGF-beta family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.427
A0A1L8EKE1	bdnf	A0A1L8EKE1	A0A1L8GDT3	NGF domain-containing protein; Belongs to the NGF-beta family.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.944
A0A1L8EKE1	bdnf-2	A0A1L8EKE1	Q63ZM5	NGF domain-containing protein; Belongs to the NGF-beta family.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.943
A0A1L8EKE1	egfr	A0A1L8EKE1	A0A1L8FRS8	NGF domain-containing protein; Belongs to the NGF-beta family.	Receptor protein-tyrosine kinase.	0.650
A0A1L8EKE1	egfr-2	A0A1L8EKE1	A0A1L8FWP8	NGF domain-containing protein; Belongs to the NGF-beta family.	Receptor protein-tyrosine kinase.	0.650
A0A1L8EKE1	ntf3	A0A1L8EKE1	A0A1L8GQU7	NGF domain-containing protein; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.504
A0A1L8EKE1	ntf3-2	A0A1L8EKE1	A0A1L8GWP4	NGF domain-containing protein; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.502
A0A1L8EKE1	plcg2	A0A1L8EKE1	A0A1L8GKY4	NGF domain-containing protein; Belongs to the NGF-beta family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.434
A0A1L8ENI2	gng7	A0A1L8ENI2	A0A1L8HN46	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.840
A0A1L8ENI2	gng7-2	A0A1L8ENI2	Q6DD50	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.840
A0A1L8EVB6	gng7	A0A1L8EVB6	A0A1L8HN46	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.840
A0A1L8EVB6	gng7-2	A0A1L8EVB6	Q6DD50	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.840
A0A1L8FNJ3	Plcg1.S	A0A1L8FNJ3	A0A310TNX3	NGF domain-containing protein; Belongs to the NGF-beta family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.427
A0A1L8FNJ3	bdnf	A0A1L8FNJ3	A0A1L8GDT3	NGF domain-containing protein; Belongs to the NGF-beta family.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.941
A0A1L8FNJ3	bdnf-2	A0A1L8FNJ3	Q63ZM5	NGF domain-containing protein; Belongs to the NGF-beta family.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.941
A0A1L8FNJ3	egfr	A0A1L8FNJ3	A0A1L8FRS8	NGF domain-containing protein; Belongs to the NGF-beta family.	Receptor protein-tyrosine kinase.	0.650
A0A1L8FNJ3	egfr-2	A0A1L8FNJ3	A0A1L8FWP8	NGF domain-containing protein; Belongs to the NGF-beta family.	Receptor protein-tyrosine kinase.	0.650
A0A1L8FNJ3	ntf3	A0A1L8FNJ3	A0A1L8GQU7	NGF domain-containing protein; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.471
A0A1L8FNJ3	ntf3-2	A0A1L8FNJ3	A0A1L8GWP4	NGF domain-containing protein; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.470
A0A1L8FNJ3	plcg2	A0A1L8FNJ3	A0A1L8GKY4	NGF domain-containing protein; Belongs to the NGF-beta family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.434