39 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	Pou5f3.1	POU domain protein. (445 aa)
	pou5f3.2	POU domain protein. (449 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	axin2	Uncharacterized protein. (707 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	calm1	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	calml4	Uncharacterized protein. (153 aa)
	wif1	Uncharacterized protein. (374 aa)
	Tjp1.S	Uncharacterized protein; Belongs to the MAGUK family. (1705 aa)
	calml4-2	Uncharacterized protein. (152 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	fzd9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
	A0A1L8H5Z7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (534 aa)
	PR-2	Uncharacterized protein. (730 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	fzd9-2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	fzd10	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	lox	Uncharacterized protein. (422 aa)
	Lox.L	Uncharacterized protein. (457 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	siah2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	pgr	Progesterone receptor. (732 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	A0A1L8H5Z7	A0A1L8ENI4	A0A1L8H5Z7	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.504
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	dkk2	A0A1L8ENI4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.665
A0A1L8ENI4	dkk2-2	A0A1L8ENI4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.666
A0A1L8ENI4	fzd10	A0A1L8ENI4	A0A1L8HQJ0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.521
A0A1L8ENI4	fzd2	A0A1L8ENI4	A0A1L8EL29	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.694
A0A1L8ENI4	nlk	A0A1L8ENI4	D2KW22	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.506
A0A1L8ENI4	siah2	A0A1L8ENI4	B7ZS60	Uncharacterized protein.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.489
A0A1L8ENI4	wif1	A0A1L8ENI4	A0A1L8GYI2	Uncharacterized protein.	Uncharacterized protein.	0.723
A0A1L8ENI4	wif1-2	A0A1L8ENI4	B7ZPZ2	Uncharacterized protein.	Wnt inhibitory factor-1.	0.723
A0A1L8ENI4	wnt11	A0A1L8ENI4	A0A1L8HJX1	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.668
A0A1L8ENI4	wnt11b	A0A1L8ENI4	A0A1L8F6W4	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.667
A0A1L8ENI4	wnt3a	A0A1L8ENI4	A0A1L8FUX8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.929